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  • 1985-1989  (1)
  • 1980-1984  (1)
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  • 1
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Cent huit malades atteints d'oesophagite par reflux ont subi une opération de Hill, associée à une vagotomie hypersélective. L'adjonction de ce type de vagotomie à l'opération anti-reflux a pour mérites de donner un meilleur accès au cardia et d'éviter les inconvénients de la vagotomie classique. Elle entraîne ainsi une réduction bénéfique du débit acide basal. Alors que le débit acide était inchangé chez les malades qui présentait des symptômes fonctionnels post opératoires, il était abaissé de façon significative chez les malades indemnes de tout trouble. Par ailleurs, la pression au niveau du sphincter inférieur de l'oesophage était toujours augmentée après l'intervention. Les complications ont été rares. 92% des malades ne présentaient aucun symptôme après 2 mois, 88% après un an et 71% après 2 ans. Une réduction remarquable des troubles pulmonaires a été remarquée, ce fait témoignant de la relation étroite qui existe entre les maladies respiratoires chroniques et le reflux gastro-oesophachez certains malades.
    Notes: Abstract Parietal cell vagotomy (PCV) and the Hill antireflux procedure were used in 108 patients with reflux esophagitis. The addition of PCV provides better access to the cardia and ensures that more extensive vagotomy than intended does not occur. Furthermore, a reduction in the basal acid output (BAO) is preferable. In patients still symptomatic after surgery, the BAO was unchanged, while in those without postoperative symptoms a significant decrease in BAO was found (p 〈 0.01). Gastroesophageal sphincter pressure was significantly higher postoperatively in all patients. Complications were few; 92% were asymptomatic at 2 months, 88% at 1 year, and 71% at 2 years. A remarkable reduction in pulmonary symptoms after operation indicates a close relationship between chronic pulmonary disease and gastroesophageal reflux in some patients.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 34 (1989), S. 1894-1899 
    ISSN: 1573-2568
    Keywords: achalasia ; eosinophils ; eosinophil cationic protein ; cytotoxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Smooth-muscle specimens from the lower esophagus of nine patients operated on for esophageal achalasia were examined with routine hematoxylin-eosin staining. This procedure revealed only a few eosinophils in or between the external smooth-muscle layers. Using specific immunohistochemical methods for the detection of the eosinophil cationic protein (ECP), however, varying degrees of eosinophil infiltration and extracellular deposit of ECP were disclosed in the achalasia specimens. The ECP also reacted with the monoclonal antibody, EG2, indicating secretion of the cytotoxic ECP. Few or no eosinophils were seen in the muscularis externa in specimens from six control patients without esophageal disease. In two controls many eosinophils were observed in the muscularis externa. However, no extracellular ECP was detected and very few eosinophils reacted with the monoclonal antibody (EG2), suggesting that these eosinophils were not activated. Depletion or total absence of peptidergic innervation was seen in all achalasia specimens but not in controls. Since the eosinophil cationic protein (ECP), in its activated form, is cytotoxic, we propose a pathogenic role of the eosinophil infiltration in achalasia.
    Type of Medium: Electronic Resource
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