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  • General Chemistry  (11)
  • Captopril  (2)
  • Human
  • Lens
  • Renin angiotensin system
  • 1985-1989  (2)
  • 1965-1969
  • 1960-1964  (11)
Document type
Publisher
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 64 (1986), S. 327-332 
    ISSN: 1432-1440
    Keywords: Severe hypertension ; Minoxidil ; Captopril
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The antihypertensive efficacy of minoxidil and captopril was compared in 23 males with essential or renal parenchymatous hypertension refractory to conventional antihypertensive drug therapy. Following a pretreatment period the patients were randomly assigned to receive either minoxidil, 2.5 mg twice daily (n=12), or captopril, 25 mg twice daily (n=11). In patients with diastolic blood pressure 〉95 mmHg, doses of minoxidil and captopril were increased in 2-week intervals. Patients who maintained diastolic pressure 〉95 mmHg and/or those with intolerable side effects were switched over to the alternative substance. After a mean observation period of 12 weeks a significant decrease in systolic and diastolic blood pressure was observed (179/114 vs 148/92 mmHg in the minoxidil group; 176/111 vs 158/97 mmHg in the captopril group). The primary response rate was 75% in patients treated with minoxidil and 55% in those with captopril (not significant). After the change to the alternative substance two of the four non-responders on captopril and one of the two non-responders on minoxidil became responders. Side effects occurred significantly more often during minoxidil than captopril (p〈0.05). The high efficacy of minoxidil and captopril in the treatment of severe hypertension refractory to conventional drugs was confirmed. Minoxidil lowered blood pressure slightly more than captopril, but it had a higher incidence of side effects than captopril.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 63 (1985), S. 361-363 
    ISSN: 1432-1440
    Keywords: Primary aldosteronism ; Captopril ; Spironolactone ; Renin-angiotensin ; Converting-enzyme ; Secondary hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In three patients with primary aldosteronism, the acute effect of a single dose of captopril on the elevated mean arterial blood pressure (MAP) was studied before and after 4 weeks of treatment with spironolactone. Before spironolactone therapy, captopril did not cause any drop in MAP. Four weeks later, after an oral daily dose of 400 mg spironolactone, MAP was still elevated in all three patients, though electrolyte abnormalities were fully corrected. Since plasma renin activity (PRA) was increased to values above the normal range, the acute effect of captopril on MAP was tested again. A single dose of 25 mg captopril then caused a fall in MAP to normal. These data reveal the conversion from a renin-independent to a renindependent kind of hypertension after spironolactone therapy in three patients with primary aldosteronism syndrome. This might be of pathogenetic and therapeutic interest.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 73 (1961), S. 612-615 
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es wird eine Methode des fraktionierten Kristallisierens und Schmelzens beschrieben, die wie die Kolonnendestillation ein echtes Gegenstromverfahren darstellt. Das neue Trennverfahren kann zur Reinigung von unzersetzt schmelzbaren, kristallisierenden Verbindungen und zur Trennung von Mischkristallsystemen dienen. Verglichen mit dem Zonenschmelzen führt es sehr viel schneller zu reinen Substanzen, wie Versuche mit Stearylalkohol, Cetylalkohol und 2.4-Dinitrotoluol ergaben.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 73 (1961), S. 277-290 
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In einem Überblick werden die kathodische Wasserstoffüberspannung und die anodische Sauerstoffüberspannung getrennt voneinander behandelt. Als theoretische Grundlage werden bei der Wasserstoffüberspannung der Volmer-Tafel- und der Volmer-Heyrowsky-Mechanismus diskutiert. Bei der Sauerstoffüberspannung werden die Theorien in zwei Gruppen aufgeteilt. In der einen Gruppe ist eine oxydische Oberflächenschicht unmittelbar am Mechanismus beteiligt, während bei der anderen Gruppe die elektrochemische Reaktion nur an einer oxydbedeckten Oberfläche ohne Beteiligung der dort befindlichen O-Atome abläft. Die Abhängigkeit von der Stromdichte, vom Elektrodenmaterial, vom pH, von der Zeit, vom Fremdionenzusatz und von der Adsorption von Fremdstoffen werden für die Wasserstoff- und Sauerstoffentwicklung experimentell und theoretisch behandelt.
    Additional Material: 26 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 73 (1961), S. 240-241 
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 75 (1963), S. 762-771 
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Bei zahlreichen Ordnungen der Arthropoden (Gliederfüßler) findet man Organe, die Wehrstoffe produzieren und speichern. Näheres über die chemische Zusammensetzung der Wehrsekrete zu erfahren, war das Ziel dieser Arbeit. Hierbei mußte man von vornherein auf viele Möglichkeiten der klassischen, organisch-chemischen Analyse verzichten, da die Tiere teilweise schwer erhältlich waren und ein Operieren mit größeren Substanzmengen sich von selbst verbot. Mit modernen chemischen und physikalischen Analysenverfahren und mit eigens für diesen Zweck entwickelten Trenn-, Reinigungs- und Anreicherungsmethoden konnten jedoch die Wehrstoffe verschiedener Familien der Gliederfüßler charakterisiert werden.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 74 (1962), S. 442-442 
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 74 (1962), S. 943-944 
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 75 (1963), S. 218-218 
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 75 (1963), S. 417-418 
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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