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  • 1990-1994  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Early development of SI cortical barrel subfield representation of forelimb in normal and deafferented neonatal rat as delineated by peroxidase conjugated lectin, peanut agglutinin (PNA) (1990)
    Springer
    Experimental brain research 81 (1990), S. 234-240 
    Details
    ISSN: 1432-1106
    Keywords: Somatosensory cortex ; Lectin receptors ; Glia ; Barrel ; Forelimb ; Pattern formation ; Development ; Peanut agglutinin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Development of the barrel field representation of the forelimb in the primary somatosensory cortex (SI) was studied in normal and deafferented neonatal rat pups by means of the peroxidase conjugated lectin peanut agglutinin (PNA), which most likely binds to radial glial cells within barrel boundaries. 1. Alterations in lectin binding were seen in animals sacrificed on postnatal day 8 (PND-8) if deafferentation took place on PND-1 (day of birth) through PND-6. 2. Deafferentation on PND-5 or on PND-6 had the least effect on lectin binding. In these animals, lectin binding was reduced, although the prospective representation was intact. 3. Deafferentation on PND-2, 3, and 4 had the greatest effect on lectin binding. In these animals, lectin binding was reduced and the prospective cortical representation was disrupted. 4. Deafferentation on PND-1 resulted in reduced lectin binding, however the prospective cortical representation was only slightly impaired compared to that in animals deafferented on PND-2, 3, and 4. 5. These results suggest that SI barrel field boundaries are important to plasticity and that a sensitive period for predevelopment of the forelimb barrels consists of postnatal days 1 through 6. Furthermore, the formation of normal SI barrel field boundaries requires an ongoing interaction between incoming afferents and radial glial cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00228112
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Early development of the SI cortical barrel field representation in neonatal rats follows a lateral-to-medial gradient: an electrophysiological study (1993)
    Springer
    Experimental brain research 92 (1993), S. 369-374 
    Details
    ISSN: 1432-1106
    Keywords: Extracellular recording ; Barrel field ; Somatosensory cortex ; Differential development ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Development of the barrel field in layer IV of SI cortex of neonatal rats was studied in vivo using electrophysiological recording techniques. This study was designed to determine (a) the earliest time SI cortex is responsive to peripheral mechanical and/or electrical stimulation and (b) whether the development of the SI cortical barrel field map of the body surface follows a differential pattern of development similar to the pattern previously demonstrated using peanut agglutinin (PNA) binding (McCandlish et al. 1989). Carbon fiber microelectrodes were used to record evoked responses from within the depth of the cortex in neonatal rats between postnatal day 1 (PND-1), defined as the day of birth, and PND-14. Evoked responses were first recorded approximately 12 h after birth. These responses in the youngest animals were of low amplitude, monophasic waveshape, and long latency, with long interstimulus intervals necessary to drive the cortex. Increases in amplitude and complexity of waveshape and decreases in latency were observed over subsequent postnatal days. The earliest responses recorded on middle PND-1 were evoked by stimulation of the face and/or mystacial vibrissae. The next responses were evoked approximately 24 h after birth (late PND-1) by stimulation of the forelimb. The last responses were evoked approximately 36 h after birth (middle PND-2), by stimulation of the hindlimb. The physiological map of the representation of the body surface follows a developmental gradient similar to the gradient observed using PNA histochemistry; however, the lectin-generated morphological map lagged approximately 48 h behind the physiological map. The representation of the body surface appears to be topographically organized as early as PND-2. Our results suggest that thalamocortical afferents have reached the developing cortical plate and are functional before glial cells are first detected. These results do not sit well with a theory of barrel field development based entirely on the role of glia in pattern formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00229024
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    Paper (German National Licenses)
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