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  • 1
    Electronic Resource
    Electronic Resource
    Mutational analysis of a variant of ARS1 from Saccharomyces cerevisiae (1992)
    Springer
    Current genetics 22 (1992), S. 175-180 
    Details
    ISSN: 1432-0983
    Keywords: ARS1 mutants ; DNA replication ; Yeast ; Single-stranded DNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A naturally occurring single base-pair G to A transition, creating a 10/11 near-match close to the essential 11 base-pair core consensus of ARS1, was used to investigate the importance of near-match sequences. The 10/11 near-match can not substitute for the core consensus since an ARS- phenotype is observed when the core consensus is deleted. However, deletion mutations revealed that this near-match together with a short palindromic sequence, also situated in the B-flanking region, comprise a single element crucial for optimal ARS function. The palindrome has the potential of forming a stemloop structure. Rather precise observations concerning the borders of the B-region were achieved. The four base pairs separating the near-match from the core consensus perform a spacing function where the identity of the bases are unimportant. However, this spacing is highly important since deletion of these four base pairs leads to an ARS- phenotype.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00351723
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  • 2
    Electronic Resource
    Electronic Resource
    A search for an essential function of the replication origin ARS1 in the life cycle of Saccharomyces cerevisiae (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 10 (1994), S. 491-496 
    Details
    ISSN: 0749-503X
    Keywords: Saccharomyces cerevisiae ; ARS1 ; DNA replication, mitotic ; DNA replication, premeiotic ; plasmid integration ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: We have investigated the significance of the chromosomal replication origin, ARS1, during the entire life cycle of yeast. This was done by substituting the chromosomal copy with a series of ars1 deletion mutants. It was shown that the ARS1 replication origin is not essential for mitotic or premeiotic DNA replication since no effect on growth, chromosomal loss rate and spore viability was observed in the ars1 mutant strains. We conclude that replication origins are abundantly, present in the yeast genome and that the removal of a single replication origin is compensated for by replication forks emanating from neighbouring origins.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320100408
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    Paper (German National Licenses)
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