Keywords:
Neurobiology.
;
Electronic books.
Type of Medium:
Online Resource
Pages:
1 online resource (455 pages)
Edition:
1st ed.
ISBN:
9780080857701
Series Statement:
Issn Series
URL:
https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=404594
DDC:
573.8
Language:
English
Note:
Front Cover -- International Review of Neurobiology, Volume 36 -- Copyright Page -- Contents -- Chapter 1. Ca2+, N-Methyl-D-aspartate Receptors, and AIDS-Related Neuronal Injury -- I. Introduction -- II. Neuronal Loss in the CNS of AIDS Patients -- III. gpl20-Induced Neuronal Injury Is Ameliorated by Calcium Channel Anotagonists -- IV. Involvement of the NMDA Receptor in gpl20-Induced Neuronal Injury -- V. Indirect Neuronal Injury Mediated by HIV-Infected or gp120-Stimulated Monocytic Cells -- VI. Possible Involvement of Astrocytes, Oligodendrocytes, and Other HIV-1 Proteins in Neuronal Injury -- VII. Overstimulation of NMDA Receptors, a Final Common Pathway -- VIII. Development of Clinically Tolerated NMDA Antagonists for HIV-Related Neuronal Injury -- IX. Excitatory Amino Acid Antagonist Treatments on the Horizon -- X. Conclusion -- References -- Chapter 2. Processing of Alzheimer Aβ-Amyloid Precursor Protein: Cell Biology, Regulation, and Role in Alzheimer Disease -- I. Introduction -- II. Alzheimer Disease Is Associated with an Intracranial Amyloidosis -- III. APP Structure Gives Clues to Some of Its Functions -- IV. APP Is Processed via Several Distinct Enzymatic and Subcellular Pathways -- V. "Alternative" Pathways of APP Metabolism Provide Clues to the Source of Aβ-Amyloid -- VI. Aβ-Amyloid Is a Normal Constituent of Body Fluids and the Conditioned Medium of Cultured Cells -- VII. Evidence Suggests the Existence of an Enzyme, β-Secretase, That Cleaves APP at the Amino Terminus of the Aβ-Amyloid Domain -- VIII. APP Mutations in Familial Cerebral Amyloidoses Occur within or near the Aβ-Amyloid Domain, Segregate with Disease in Affected Kindreds, and Yield APP Molecules That Display Some Proamyloidogenic Properties -- IX. Signal Transduction via Protein Phosphorylation Regulates the Relative Utilization of APP Processing Pathways.
,
X. Beyond Aβ-Amyloid: Other Molecular Factors in Amyloidogenesis and Factors Differentiating Aging-Related Cerebral Amyloidosis from Alzheimer Disease -- References -- Chapter 3. Molecular Neurobiology of the GABAA Receptor -- I. Introduction -- II. Pharmacology of the GABAA Receptor -- III. Biochemistry -- IV. Molecular Cloning of Receptor Subunits -- V. Characterization of the Receptor Family -- VI. The Future -- Reference -- Chapter 4. The Pharmacology and Function of Central GABAB Receptors -- I. Introduction -- II. Pharmacology of GABAB Receptors -- III. Properties of GABAB Receptors -- IV. Function of GABAB Receptors -- V. Summary and Conclusions -- References -- Chapter 5.The Role of the Amygdala in Emotional Learning -- I. Introduction -- II. Morphology -- III. Electrophysiology -- IV. Anatomical Connections between the Amygdala and Brain Areas Involved in Fear and Anxiety -- V. Elicitation of Fear by Electrical or Chemical Stimulation of the Amygdagdala -- VI. Effects of Amygdala Lesions on Conditioned Fear -- VII. Effects of Amygdala Lesions on Unconditioned Fear -- VIII. Effects of Local Infusion of Drugs into the Amygdala on Measures of Fear and Anxiety -- IX. The Role of the Amygdala in Attention -- X. The Amygdala Is Critical for the Fear-Potentiated Startle Effect -- XI. Are Aversive Memories Actually Stored in the Amygdala? -- XII. Is the Amygdala Absolutely Essential for Fear-Potentiated Startle? -- XIII. Can Initial Fear Conditioning Occur without the Amygdala? -- XIV. The Role of Excitatory Amino Acid Receptors in the Amygdala in Fear Conditioning -- XV. Conclusions -- References -- Chapter 6. Excitotoxicity and Neurological Disorders: Involvement of Membrane Phospholipids -- I. Introduction -- II. Classification of Excitatory Amino Acid Receptors.
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III. Excitatory Amino Acid Receptors and Neural Membrane Phospholipid Metabolism . . . -- IV. Role of Enhanced Excitatory Amino Acid-Mediated Phospolipid Metabolism in Developing Brain -- V. Possible Mechanism of Cell Injury Caused by Excitatory Amino Acids -- VI. Excitatory Amino Acid Receptors, Phospholipid Metabolism, and Neurological Disorders -- VII. Excitatory Amino Acid Receptor Antagonists and the Treatment of Neurological Disorders -- VIII. Conclusion -- IX. Summary -- References -- Chapter 7. Injury-Related Behavior and Neuronal Plasticity: An Evolutionary Perspective on Sensitization, Hyperalgesia, and Analgesia -- I. Introduction -- II. Evolutionary Considerations -- III. Adaptive Behavioral Reactions to Injury -- IV. Classes of Injury-Related Behavioral Modifiability -- V. Injury Signals -- VI. Mechanisms of Rapid Nociceptive Sensitization -- VII. Mechanisms of Long-Term Nociceptive Sensitization -- VIII. Conclusions -- References -- Index -- Contents of Recent Volumes.
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