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T-Cell Immunity to Acetylcholine Receptor and its Subunits in Lewis Rats over the Course of Experimental Autoimmune Myasthenia Gravis (1993)

WANG, Z.-Y. ; LINK, H. ; HUANG, W.-X.

Oxford, UK : Blackwell Publishing Ltd

Scandinavian journal of immunology 37 (1993), S. 0

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ISSN: 1365-3083

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Lymph nodes, spleen and thymus obtained from Lewis rats were examined over the course of experimental autoimmune myasthenia gravis (EAMG) for the distribution and the number of antigen-reactive CD4+ T helper cells which, upon recognition of Torpedo acetylcholine receptor (AChR) or the α, β, γ or δ subunits of Torpedo AChR, responded by secretion of interferon-gamma (IFN-γ). T cells with these specificities were detected in these three immune organs. Numbers were highest in lymph nodes. In spleen and thymus, numbers of antigen-reactive T cells did not differ. T cells reacting against the intact AChR were more frequent than T cells recognizing any of the subunits. The immunogenicity between the four subunits did not differ, with the exception that the α subunit induced a slightly higher T-cell response. No restriction of the T-cell repertoire to the four subunits was detected during early compared to late phases of EAMG. The AChR and subunit-reactive T cells could—via secretion of effector molecules including IFN-γ—play an important role in the initiation and perpetuation of EAMG. and consequently also of human myasthenia gravis. T cells with the same specificities were also detected in control animals injected with adjuvant only, but at much lower numbers which were within the range of T cells recognizing the control antigen myelin basic protein. They could represent naturally occurring autoimmune T cells.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-3083.1993.tb02580.x

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FTIR investigation of cross-linking and isomerization reactions of acetylene-terminated polyimide and polyisoimide oligomers (1994)

Huang, W. X. ; Wunder, S. L.

Bognor Regis [u.a.] : Wiley-Blackwell

Journal of Polymer Science Part B: Polymer Physics 32 (1994), S. 2005-2017

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ISSN: 0887-6266

Keywords: FTIR spectroscopy ; acetylene-terminated polyisoimide ; acetylene-terminated polyimide ; isoimide-imide isomerization ; cross-linking reaction ; thermal curing process ; flexibility effect ; cross-linking effect ; rate constant ; Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Physics

Notes: The interrelationship between the cross-linking and isoimide-imide isomerization reactions of oligomeric isoimides and imides was investigated using FTIR spectroscopy. It was found that cross-linking of the acetylene units of Thermid IP-600 retarded the local rearrangement of the isoimide to imide conversion of Thermid IP-600 compared with an aniline-terminated analog, decreasing the rate constant by a factor of about 2. The increased flexibility of both the isoimide (Thermid IP-600) and imide (Thermid FA-700) oligomers increased the cross-linking rate of the acetylene end groups by a factor of 4 and 2, respectively, over that of the more rigid imide oligomer (MC-600). With increasing conversion of the isoimide to imide linkages in Thermid IP-600, the kinetic parameters, Eα and in A, for the cross-linking reaction of this oligomer became the same as those for the oligomeric imide, Thermid MC-600. © 1994 John Wiley & Sons, Inc.

Additional Material: 10 Ill.