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  • 1
    Electronic Resource
    Electronic Resource
    Comparison of the role of nasal polyp and normal nasal mucosal epithelial cells on in vitro eosinophil survival. Mediation by GM–CSF and inhibition by dexamethasone (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 24 (1994), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Eosinophilic infiltration of the respiratory mucosa is considered an inflammatory hallmark of allergic rhinitis, bronchial asthma and nasal polyposis. However, the mechanisms involved in this infiltration have not yet been totally elucidated. The objective of this study was to investigate and compare the influence of epithelial cell secretions from both nasal polyps (NP) and normal nasal mucosa (NM) on in vitro eosinophil survival. Epithelial cells were identified by microscopy; and immunohislochemisiry. cultured to confluence, and human epithelial cell conditioned media (HECM) was generated from cultures. Eosinophits were isolated at high viability and purity (〉90%) from peripheral blood and incubated with HECM. HECM from both NM and NP increased eosinophil survival in a dose-dependent manner, this effect being maximal at a concentration of 25% for NM (73.4%±5.5%, n= 26, P〈 0.001) and of 10% for NP (74.5%± 84%n= 18, P 〈 0.001). Incubation of monoclonal antibody to human GM-CSF with HECM, neutralized the induction of eosinophil survival by HECM from both NM and NP. HECM from NP contained higher concentrations of GM-CSF (111 ± 25.4 pg/ml, n= 17) than HECM from NM (97.1 ± 15.2 pg/ml. n= 8). without reaching statistical significance. Pre-incubation of dexamethasone with eosinophils also blocked HFCM-induced eosinophil survival from both NM (10−8-10−5 M; IC50 = 9.5 nM) and NP (10-7-10-5 M; IC50 = 83 nM). These results suggest that: firstly eosinophil infiltration into the respiratory mucosa during allergic reaction and nasal polyposis may be modulated at least in part by GM-CSF from epithelial cells; and secondly epithelial cells from NP might have a more potent effect on inducing eosinophil infiltration of the respiratory mucosa than epithelial cells from NM. Finally, we may consider this as a reliable in vitro model to compare the role of epithelial cells from inflammatory (NP) and non-inflammatory (NM) tissue in respiratory inflammation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1994.tb00240.x
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  • 2
    Electronic Resource
    Electronic Resource
    Topological Linearly Ordered Spaces Determined by Pervin's Quasi-uniformity (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 728 (1994), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Notes: : In this paper we study those uniform linearly ordered spaces that are determined by Pervin's quasi-uniformity. In particular, we show that the space of all countable ordinals is determined by a unique quasi-uniformity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1994.tb44129.x
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  • 3
    Electronic Resource
    Electronic Resource
    Some exact results for the anderson model of an impurity (1990)
    Springer
    Il nuovo cimento della Società Italiana di Fisica 12 (1990), S. 53-59 
    Details
    ISSN: 0392-6737
    Keywords: General theory and models of magnetic ordering
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Description / Table of Contents: Riassunto Si ottengono formule generali per la valenza, la carica e suscettibilità di spin e per il calore specifico a temperatura bassa e campo magnetico zero per il modello di Anderson di un'impurità con l'uso del metodo dell'ansatz di Bethe seguendo il lavoro di Tsvelick e Wiegmann.
    Abstract: Резюме Получаются общие формулы для валентности, заряда, спиновой восприимчивости и удельной теплоемкости при низкой температуре и нулевом магнитном поле для модели Андерсона для описания примеси с использованием подхода Бете.
    Notes: Summary General formulae for the valence, charge and spin susceptibility, and specific heat at low temperature and zero magnetic field are obtained for the Anderson model of an impurity with the use of the Betheansatz method, following the work of Tsvelick and Wiegmann.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02453026
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  • 4
    Electronic Resource
    Electronic Resource
    Human pancreatic islet function at the onset of Type 1 (insulin-dependent) diabetes mellitus (1993)
    Springer
    Diabetologia 36 (1993), S. 358-360 
    Details
    ISSN: 1432-0428
    Keywords: Human islets ; islet function ; onset of Type 1 (insulin-dependent) diabetes mellitus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Viable human pancreatic islets isolated from a recent-onset Type 1 (insulin-dependent) diabetic patient were used to perform in vitro studies. Pre-proinsulin mRNA and insulin content, as well as insulin response were analysed. Insulin response to glucose and forskolin was completely absent in diabetic islets, as compared to control islets. Insulin content was reduced to only one-third of control values (395.0±3.5 vs 989.0±46.3 μU/islet) and 20.7±3.9% of islets from the diabetic pancreas contained insulin-positive cells in immunofluorescence studies. Northern blot analysis revealed a severe reduction in the content of pre-proinsulin mRNA in diabetic pancreatic tissue. Our results indicate that although markedly decreased, beta cells in human pancreatic islets at the onset of Type 1 diabetes are still present. Never-theless, pancreatic islet function is disproportionately impaired with a complete absence of an insulin response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400241
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  • 5
    Electronic Resource
    Electronic Resource
    Algebras of sets generating non-barrelled spaces (1994)
    Springer
    Periodica mathematica Hungarica 29 (1994), S. 207-211 
    Details
    ISSN: 1588-2829
    Keywords: Primary 46A07 ; Secondary 28C99 ; Key words and phrases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract IfA is a σ-algebra on setX, thenl 0 ∞ (X,A) is a barrelled space of class χ0. IfA is an algebra, there are conditions which imply thatl 0 ∞ (X,A) is suprabarelled. Here, wheneverA is an algebra, we give conditions forl 0 ∞ (X,A) to be not barrelled which are related with the existence of non-trivial convergent sequences.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01875850
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