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  • 1
    Electronic Resource
    Electronic Resource
    Structure of 2-(2,6-dimethoxyphenyl)-7-hydroxy-4H-1-benzopyran-4-one (7-hydroxy-2',6'-dimethoxyflavone) (1992)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 48 (1992), S. 86-88 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270191006285
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  • 2
    Electronic Resource
    Electronic Resource
    Crystal and molecular structure of 2′,4′-dimethoxyflavone (1993)
    Springer
    Journal of chemical crystallography 23 (1993), S. 297-300 
    Details
    ISSN: 1572-8854
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract C17H14O4,M r =282.3, triclinic,P-1,a=8.469(3),b=8.516(2),c=20.425(8)Å,α=84.95(3),β=81.98(3), γ=70.47(2)°,V=1373(13)Å3,Z=4,D x =1.365 g cm−3, λ(MoK α)=0.71069 Å,μ=0.91 cm−1,F(000)=592,T=294K,R=0.038 for 3577 observed reflections (F〉3σ (F)). The asymmetric unit is composed of two molecules. These two molecules, which are in planar conformations, differ in 4′-methoxyl group orientation. Short intramolecular contacts are found between the γ-benzopyran portion and the dimethoxyphenyl ring.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01263590
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  • 3
    Electronic Resource
    Electronic Resource
    p 53 gene rearrangements in chronic myelocytic leukemia (1993)
    Springer
    Annals of hematology 66 (1993), S. 81-83 
    Details
    ISSN: 1432-0584
    Keywords: p 53 Gene ; CML ; Rearrangements ; Deletions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We performed Southern-blot analysis of the p 53 gene in 41 consecutive patients with typical chronic myelocytic leukemia (CML). In two of them, we were able to study cells during both the chronic and the accelerated phases. Only one of the 29 chronic-phase samples had rearrangement of the p 53 gene, whereas three of the nine accelerated-phase samples and one of the five patients in blast crisis exhibited rearrangements. Gene deletion was observed in two patients, one in accelerated phase and the other in blast crisis. One patient with a nonrearranged p 53 gene in chronic phase showed rearrangement after progression to the accelerated phase. On the other hand, one patient in accelerated phase exhibited rearrangements which disappeared after reversion to chronic phase with successful treatment. Our findings support the opinion that alterations of the p 53 gene may play an important role in CML evolution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01695889
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  • 4
    Electronic Resource
    Electronic Resource
    Further evidence for the molecular heterogeneity of chronic myeloid leukemia (1991)
    Springer
    Annals of hematology 62 (1991), S. 217-220 
    Details
    ISSN: 1432-0584
    Keywords: Chronic myeloid leukemia ; Molecular analysis ; Cytogenetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cytogenetic and molecular techniques were performed on samples obtained from 29 patients with chronic myelocytic leukemia (CML); 27 were in the chronic phase and two were in blast crisis. A further five cases were also analyzed, two with atypical CML (aCML), one with chronic neutrophilic leukemia (CNL), and two with juvenile CML (JCML). Most of the cases with typical CML were Philadelphia chromosome (Ph) positive and had a rearrangement within the major breakpoint cluster region (M-bcr). One of these cases was shown to be Ph positive but showed no rearrangement within the M-bcr. Two cases with clinical features typical of CML were Ph negative. One of these showed a rearrangement within the M-bcr, but no rearrangement was demonstrated in the other. Both patients in blast crisis were Ph positive and M-bcr positive. One showed a second Ph. Patients with aCML were Ph negative and had no M-bcr rearrangement. A polymorphism within the M-bcr was found withBglII in one case. No Ph chromosome or M-bcr rearrangement was found in CNL or JCML. These data support the molecular heterogeneity reported in CML.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01729835
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  • 5
    Electronic Resource
    Electronic Resource
    All-trans retinoic acid in acute promyelocytic leukemia: Preliminary results in Cuba (1992)
    Springer
    Annals of hematology 65 (1992), S. 121-123 
    Details
    ISSN: 1432-0584
    Keywords: Retinoic acid ; Acute promyelocytic leukemia ; Disseminated intravascular coagulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seven patients with acute promyelocytic leukemia (APL) were treated with all-trans retinoic acid (ATRA). Five (71.4%) achieved complete remission (CR). Most side effects were transient and well tolerated. Hyperleukocytosis was the major adverse effect. These observations confirm the efficacy of ATRA for inducing CR in APL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01695810
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  • 6
    Electronic Resource
    Electronic Resource
    Bone metastases as the first manifestation of a tumour (1991)
    Springer
    International orthopaedics 15 (1991), S. 373-376 
    Details
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Revue de 29 dossiers de malades chez qui le premier signe de néoplasie était une métastase osseuse. Deux des cancers primitifs ont pu être identifiés: l'un du poumon et l'autre de l'utérus, et dans deux cas on a posé le diagnostic présumé de tumeur du sein et de la prostate. Quand on découvre une métastase osseuse et que le cancer primitif n'est pas connu le bilan doit comporter une anamnèse, un examen clinique, les tests habituels de laboratoire et des radiographies pulmonaires. Une mammographie peut être demandée chez la femme, surtout s'il existe une adénopathie axillaire palpable. On ne pratiquera un examen tomodensitométrique de l'abdomen et une bronchoscopie que si des arguments cliniques les justifient.
    Notes: Summary We have reviewed 29 patients whose first sign of a tumour was a bone metastasis. Two primaries were identified, lung adenocarcinoma and uterine adenocarcinoma and in 2 cases a presumptive diagnosis of tumours of the breast and prostate was made. The mean survival time was 3 months. When bone metastases are found in the absence of a primary tumour, investigation must include a clinical history, physical examination, routine laboratory tests and chest radiographs. Mammography should be done in women, particularly when there are palpable axillary nodes. Abdominal CT scanning and bronchoscopy should only be undertaken when there is a clinical indication.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00186882
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  • 7
    Electronic Resource
    Electronic Resource
    Nutritional factors affecting lipase production byRhizopus delemar CDBB H313 (1990)
    Springer
    Biotechnology letters 12 (1990), S. 209-214 
    Details
    ISSN: 1573-6776
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary Some nutritional factors that affect lipase yields byRhizopus delemar were studied. Dextrin proved to be the best carbon source when used at 1% level. Yeast extract was the best nitrogen source for lipase production. The presence of a lipidic source in the growth medium, at a level not higher than 2% resulted in higher enzyme production. Tween 80 exerted a positive effect on enzyme production, used in a range that goes from 0.02% to 2.00%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01026801
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