ISSN:
0749-1581
Keywords:
1H NMR
;
Somatostatin analogues
;
Conformational study in methanol
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The conformations of three somatostatin analogues were compared in methanol at 193 K. A biologically active cyclic analogue, DC13-116 (D-Nal5-Cys6-Tyr7-D-Trp8-Lys9-Val10-Cys11-Thr12-NH2), and two linear analogues, one biologically active, DC25-24 (D-Phes5-Cpa6-Tyr7-D-Trp8-Lys 9-Val10-Phe11-Thr12-NH2), and one with poor biological activity, DC23-89 (D-Phe5-Ala6-Phe7-D-Trp8-Lys9-Thr10-Ala11-Thr12-NH2), were compared. The predominant conformation of the linear active analogue is shown to be the same as that of the active cyclic analogue; they both adopt a β11 turn/β-sheet structure. The linear analogue with low activity has a similar conformation, which, however, is less stable.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260290612
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