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  • 1990-1994  (16)
  • 11
    Electronic Resource
    Electronic Resource
    Measurement of Allergen-Specific IgD and Correlation with Allergen-Specific IgE (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 40 (1994), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A new method for the measurement of allergen-specific IgD (as-IgD) was developed by modifying the ImmunoCAP assay (Pharmacia), and amplification of the signal with a goat anti-human/rabbit antigoat detection system. The assay was sensitive enough to measure as-IgD in serum samples. The specificity of the assay was examined using inhibition tests with excess corresponding and non-corresponding allergens. For the different allergens inhibition rates between 56% (house dust mite) and 88% (cat) could be achieved. Non-corresponding allergens did not inhibit the as-IgD binding. Total IgE and allergen-specific IgE (as-IgE) was measured using the ImmunoCAP system. Total IgD was measured using a sandwich ELISA. As-IgD was measured in serum samples from 51 atopic and 2.1 non-atopic subjects, and the correlation with as-IgE was examined. As-IgD was detected in both atopies and non-atopies but at higher levels in atopies. As-IgD against birch pollen and timothy pollen allergen was found to be increased in atopies with IgE directed against these allergens compared to atopies without IgE against these allergens (P 〈0.02 and P 〈0.03). As-IgD against birch pollen allergen was higher in atopies with IgE specific to this allergen than in non-atopies (P 〈0.02). In contrast to total IgE and total IgD, significant correlations were observed between as-IgD and as-IgE against timothy pollen (r= 0.34, P 〈0.04), birch pollen (r= 0.38, P 〈0.05) and cat dander allergen (r= 0.52, P 〈0.01). The observed correlations between as-IgD and IgE suggest that IgD and IgE may be similarly regulated, and thus the measurement of as-IgD may give further insight into the regulation of IgE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1994.tb03496.x
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  • 12
    Electronic Resource
    Electronic Resource
    Comparative efficacy of azelastine nasal spray and terfenadine in seasonal and perennial rhinitis (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 49 (1994), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The efficacy and tolerability of intranasal azelastine (0.14 mg/nostril twice daily) and oral terfenadine (60 mg twice daily) were compared under double-blind conditions in two 6-week, multicenter, parallel-group studies, including 167 patients suffering from seasonal and 52 patients suffering from perennial allergic rhinitis. In both studies, patients were symptomatic on entry and showed significant improvement on both treatments within the first 8 d of therapy, showing little further improvement with continued treatment. Symptoms most pronounced on entry – nasal itching, rhinorrhea, sneezing, and nasal obstruction – responded best to treatment (response rates 80–90%). Objective signs such as mucosal swelling and conjunctivitis improved in a manner parallel to symptoms. In perennial rhinitis, azelastine showed a trend to a superior relief of rhinorrhea and nasal obstruction, whereas terfenadine showed a trend toward better control of sneezing and nasal itchiness. No clinically relevant or statistically significant differences between treatments could be identified. The incidence of adverse effects of possible causal relationship to therapy was low. The most frequent effects in azelastine-treated patients were related to application site disorders, e.g., nasal irritation. Results indicate that with the dose used azelastine nasal spray is an effective treatment for both seasonal and perennial allergic rhinitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1994.tb00818.x
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  • 13
    Electronic Resource
    Electronic Resource
    Influence of histamine H3-antagonists on human leukocytes (1990)
    Springer
    Inflammation research 30 (1990), S. 137-139 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To determine the role of the histamine H3-receptor on basophils, different specific H3-antagonists were investigated. Incubation of washed leukocytes with Nα-acylated histamine-derivatives (Nα-ahd) induced elevated histamine levels. This process turned out to be dependent on dose, time and temperature, but independent of Ca2+ and Mg2+ ions. IgE-mediated histamine release was not modulated. [3H]-l-histidine was not decarboxylated into [3H]-histamine in spite of the observed histamine increase. Highly purified basophils did not show any histamine elevation but purified neutrophils and eosinophils were found to have increased histamine levels even after disintegration and subsequent incubation with Nα-ahd. It seems that the increased histamine levels result from the cleavage of the applied histamine amides. Other potent H3-antagonists (e.g. thioperamide) neither produced increased histamine levels nor influenced IgE-mediated release from basophil leukocytes. The existence of H3-receptors on human basophils therefore seems unlikely.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01969020
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  • 14
    Electronic Resource
    Electronic Resource
    Modulation of IgE-mediated histamine release from human leukocytes by a new class of histamine H2-agonists (1992)
    Springer
    Inflammation research 35 (1992), S. 185-191 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A new class of phenyl (pyridylalcyl) guanidines, acting as potent histamine H2-agonists, inhibits IgE-mediated human basophil histamine release in a nanomolar range. IC30-level of three substitutes of this group (arpromidine, BUA-75, and FRA-19) were found to be 0.02, 0.015 and 0.008 μM. The inhibition appeared with a fast onset (plateau after 10 min. preincubation) and claimed its maximum (60±2.9%, 63±1.8%, and 61±3.1%,n=7) with 10 μM of the compounds. H2-mediated inhibition was totally blocked by 10 μM famotidine, a potent histamine H2-antagonist. The amount of anti-IgE or antigen for the initiation of the immunological release influenced the strength of inhibition of H2-agonist FRA-19 (p〈0.05). Combined preincubation of FRA-19 with zardaverine, a cAMP-specific phosphodiesterase III/IV inhibitor, produced a synergistical inhibitory effect of leukocyte histamine release, which might explained by their different sites of action on intracellular cAMP levels. The capability of histamine to inhibit its own release is mediated by H2-receptors exclusively. New, potent H2-receptor stimulating compounds with positive inotropic effects possess additional potent anti-allergic properties.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01997498
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  • 15
    Electronic Resource
    Electronic Resource
    Kinin generation following methacholine nasal airway challenge of non-allergic subjects (1992)
    Springer
    European archives of oto-rhino-laryngology and head & neck 249 (1992), S. 318-321 
    Details
    ISSN: 1434-4726
    Keywords: Chronic non-allergic rhinitis ; Kinins ; Methacholine challenge ; Muscarinic receptor stimulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Following nasal challenges with the muscarinic neurotransmitter methacholine in 14 patients with chronic non-allergic rhinitis, kinin generation was induced. This occurrence was inhibited by pretreatment with anticholinergic agents (ipratropium bromide) and by an overdose of neurotransmitter, indicating that a muscarinic receptor is stimulating the liberation of kinin. These observations suggest that patients with chronic non-allergic rhinitis exhibit cholinergic neurotransmitter-induced kinin generation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00179380
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  • 16
    Electronic Resource
    Electronic Resource
    Book reviews (1990)
    Springer
    GeoJournal 20 (1990), S. 75-80 
    Details
    ISSN: 1572-9893
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02440058
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