In:
International Journal of Cancer, Wiley, Vol. 52, No. 1 ( 1992-08-19), p. 124-129
Abstract:
Human uterine leiomyosarcoma is a rare gynecological malignancy with a generally poor prognosis. We have established a human uterine leiomyosarcoma tumor line in nude mice, designated UTS‐1, and describe the characteristics of this tumor. The UTS‐1 tumor doubled in 12.1 days and retained the histological characteristics of leiomyosarcoma, even after 14 serial generations. Ultrastructurally, the tumor is characterized by nuclear pleomorphism typical of smooth muscle, intracyto‐plasmic filaments with dense bodies, a relative paucity of micropinocvtotic vesicles, and an incomplete external lamina. Immunohistochemically, the UTS‐1 cells reacted with antibodies against vimentin, desmin, smooth‐muscle actin and myosin, but not with antibodies against keratin, CEA and S‐100 protein. Serum levels of AFP, CAI25, CEA and SCC ranged within normal limits in tumor‐bearing mice. The serum level of immu‐nosuppressive acidic protein correlated well with an activity of the tumor. Estrogen and progesterone receptors were not detected in the tumor. Chromosomal analysis showed a human karyotype with some marker chromosomes and a modal number of 85 chromosomes. The UTS‐1 tumor should prove a useful model to explore the biological characteristics and treatment of human uterine leiomyosarcoma. © 1992 Wiley‐Liss, Inc.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
DOI:
10.1002/ijc.2910520122
Language:
English
Publisher:
Wiley
Publication Date:
1992
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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