In:
International Journal of STD & AIDS, SAGE Publications, Vol. 2, No. 1 ( 1991-01), p. 37-40
Abstract:
We enrolled 253 HIV-antibody positive heroin addicts without HIV-related disease ( n = 81) or with persistent generalized lymphadenopathy ( n = 172) in a prospective study to evaluate clinical progression to AIDS related complex (ARC) or AIDS and to identify factors of possible prognostic relevance. Follow-up lasted between 6 and 40 months (median 12 months). According to the non-parametric Cox's model the only significant ( P 〈 0.001) prognostic variable was T4+ cell count considered in three classes: 〉 800/μl (no depletion), 400–800/μl (moderate depletion) and 〈 400/μl (absolute depletion). Subjects with T4+ cell count of 〈 400/μl had a risk of developing ARC or AIDS that was 6.46 and 1.98 higher than those with values of 〉 800/μl or between 400 and 800/μl respectively. The estimated probability of progression to ARC or AIDS was 0.029, 0.056 and 0.172 at one year in subjects with T4+ cell count of 〉 800/μl, 400–800/μl and 〈 400/μl, respectively, and 0.2%, 0.501, and 0.896 at two years.
Type of Medium:
Online Resource
ISSN:
0956-4624
,
1758-1052
DOI:
10.1177/095646249100200107
Language:
English
Publisher:
SAGE Publications
Publication Date:
1991
detail.hit.zdb_id:
2009782-7
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