In:
Proceedings, annual meeting, Electron Microscopy Society of America, Cambridge University Press (CUP), Vol. 48, No. 3 ( 1990-08-12), p. 350-351
Abstract:
The knowledge about the state of viral replication over the course of infection with the Human Immunodeficiency Virus type 1 (HIV-1) is still incomplete in spite of its important implications for the pathogenesis and transmission of AIDS. Silent HIV-1 infections might take place after the initial encounter with the virus; infected persons may remain seronegative for prolonged periods, suggesting that in this state very little, if any, viral RNA or protein is made and infectious virus is not released. In anti-HIV seropositive yet healthy individuals (“healthy carriers”), earlier studies using viral isolation techniques from peripheral blood mononuclear cells (PBMC) have also contributed to the notion that the number of infected cells in this subjects is low (at most 1 in 100 in 1 case only). Present reports on the presence of free virus in plasma or on antigen expression in sera or in cells are still scarce and controversial.
Type of Medium:
Online Resource
ISSN:
0424-8201
,
2690-1315
DOI:
10.1017/S0424820100159291
Language:
English
Publisher:
Cambridge University Press (CUP)
Publication Date:
1990
SSG:
11
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