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  • 1
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    Online Resource
    Turnover and Oxidation Rates of Plasma-Free Fatty Acids in Obese Patients Treated with Dexfenfluramine
    S. Karger AG ; 1993
    In:  Annals of Nutrition and Metabolism Vol. 37, No. 5 ( 1993), p. 237-244
    Details
    In: Annals of Nutrition and Metabolism, S. Karger AG, Vol. 37, No. 5 ( 1993), p. 237-244
    Type of Medium: Online Resource
    ISSN: 1421-9697 , 0250-6807
    URL: Article
    DOI: 10.1159/000177773
    Language: English
    Publisher: S. Karger AG
    Publication Date: 1993
    detail.hit.zdb_id: 1481977-6
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  • 2
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    Online Resource
    Infrapopliteal Bypass Grafting for Limb Salvage In Diabetic Patients
    SAGE Publications ; 1990
    In:  Vascular Surgery Vol. 24, No. 6 ( 1990-07), p. 394-399
    Details
    In: Vascular Surgery, SAGE Publications, Vol. 24, No. 6 ( 1990-07), p. 394-399
    Abstract: A four-year prospective study of distal revascularization in diabetics with trophic damage of the limbs is presented. Thirty-two infrapopliteal bypasses in 32 limbs of 31 diabetic patients were performed. One-year and three-year graft patency rates were 68% and 59% respectively. Limb salvage was obtained in every case of surgical success.
    Type of Medium: Online Resource
    ISSN: 0042-2835
    URL: Article
    DOI: 10.1177/153857449002400604
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1990
    detail.hit.zdb_id: 2095223-5
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  • 3
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    Online Resource
    Serum and biliary lipid pattern in rabbits feeding a diet enriched with unsaturated fatty acids
    Elsevier BV ; 1990
    In:  Experimental Pathology Vol. 40, No. 1 ( 1990-1), p. 19-33
    Details
    In: Experimental Pathology, Elsevier BV, Vol. 40, No. 1 ( 1990-1), p. 19-33
    Type of Medium: Online Resource
    ISSN: 0232-1513
    URL: Article
    DOI: 10.1016/S0232-1513(11)80281-1
    Language: English
    Publisher: Elsevier BV
    Publication Date: 1990
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  • 4
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    Online Resource
    Kinetics and Thermogenesis of Medium‐Chain Monocarboxylic and Dicarboxylic Acids in Man: Sebacate and Medium‐Chain Triglycerides
    Wiley ; 1993
    In:  Journal of Parenteral and Enteral Nutrition Vol. 17, No. 3 ( 1993-05), p. 257-264
    Details
    In: Journal of Parenteral and Enteral Nutrition, Wiley, Vol. 17, No. 3 ( 1993-05), p. 257-264
    Abstract: The effects on oxygen consumption and carbon dioxide production of a constant intravenous infusion of 0.15 g of disodium sebacate (Sb), the sodic salt of a medium‐chain dicarboxylic acid with 10 carbon atoms, per kilogram of body weight per hour over 5 hours and of a 50% mixture of medium‐and long‐chain triglycerides (MCT/LCT) were compared in 10 healthy men. Oxygen consumption and carbon dioxide production were measured by indirect calorimetry. Mean oxygen consumption was about 19% higher than the basal oxygen consumption at the end of MCT/LCT infusion but was only 5% higher than the basal oxygen consumption when Sb was infused. There was an eightfold increase in plasma β‐hydroxybutyrate and acetoacetate concentrations and a threefold increase in serum insulin levels during MCT/LCT infusion, but no significant change in ketone bodies and insulin from basal values was observed during and after Sb infusion. Pharmacokinetic parameters were also computed, showing an average apparent volume of distribution of 167 mL/kg of body weight for MCTs and 112 mL/kg of body weight for Sb. The t ½ of MCTs was 50 minutes and that of Sb was 78 minutes. Urinary excretion of Sb and its β‐oxidative by‐product, suberic acid, globally accounted for 48% of the given amount of Sb. In spite of its urinary loss and slower tissue uptake compared with MCTs, Sb avoided ketone body formation or elevation in insulin levels and did not induce a significant increase in oxygen consumption. The Sb caloric equivalent was 6.643 kcal/g, and the remaining amount of Sb administered (approximately 5.2 g/h in a 70‐kg subject) seemed to be energetically useful by furnishing 34.54 kcal/h, ie, 829 kcal over 24 hours. This caloric support is equivalent to or even higher than that usually given as MCTs; however, formation of ketone bodies and interference with glucose metabolism are avoided. ( Journal of Parenteral and Enteral Nutrition 17 :257–264, 1993)
    Type of Medium: Online Resource
    ISSN: 0148-6071 , 1941-2444
    URL: Article
    DOI: 10.1177/0148607193017003257
    Language: English
    Publisher: Wiley
    Publication Date: 1993
    detail.hit.zdb_id: 2170060-6
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  • 5
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    Tissue Uptake and Oxidation of Disodium Sebacate in Man
    Wiley ; 1991
    In:  Journal of Parenteral and Enteral Nutrition Vol. 15, No. 4 ( 1991-07), p. 454-459
    Details
    In: Journal of Parenteral and Enteral Nutrition, Wiley, Vol. 15, No. 4 ( 1991-07), p. 454-459
    Abstract: In order to better ascertain its possible use as an alternative fuel substrate in total parenteral nutrition, sebacate (Sb) metabolism was studied in seven overnight‐fasting healthy male volunteers, who received a constant iv infusion (99 mmoles over 8 hours) of disodium sebacate. Sb oxidation rate was determined using an isotopic sebacate (disodic salt of (1–10) 14 C‐sebacic acid) infusion (100 μCi from the fourth to the eighth hour of the cold sebacate infusion). Blood samples were collected during and after sebacate infusion at intervals of 30 minutes and Sb serum concentrations were determined by high performance liquid chromatography. Excreted radioactivity (μCi/min) was measured by bubbling the expired air into an apparatus containing 3 mEq hyamine to trap CO 2 from a 20‐L Douglas‐bag. CO 2 production and O 2 consumption were measured before and at 4 and 8 hours after starting the infusion. Twenty‐four hour nitrogen excretion with urine was obtained. The RQ and the percent of calories derived from lipid oxidation were calculated by indirect calorimetry. The Sb serum level at the plateau phase was (mean ± SD) 4.54 ± 0.71 μmole/mL, the overall rate of tissue uptake was 180.89 ± 4.50 μmole/min, and the percent oxidation was 6.14 ± 0.44%. At the end of Sb infusion the RQ dropped to 0.839 ± 0.043, the percent of calories due to sebacate oxidation was 1.59 ± 0.52%, and the calories derived from lipids increased to 37.77 ± 12.90%. These data show that a definite amount of the sebacate infused is oxidized in human tissues. ( Journal of Parenteral and Enteral Nutrition 15: 454–459, 1991)
    Type of Medium: Online Resource
    ISSN: 0148-6071 , 1941-2444
    URL: Article
    DOI: 10.1177/0148607191015004454
    Language: English
    Publisher: Wiley
    Publication Date: 1991
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  • 6
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    Online Resource
    Pharmacokinetic Profile of Dodecanedioic Acid, a Proposed Alternative Fuel Substrate
    Wiley ; 1994
    In:  Journal of Parenteral and Enteral Nutrition Vol. 18, No. 3 ( 1994-05), p. 225-230
    Details
    In: Journal of Parenteral and Enteral Nutrition, Wiley, Vol. 18, No. 3 ( 1994-05), p. 225-230
    Abstract: Dodecanedioic acid (C12), a saturated, aliphatic dicarboxylic acid with 12 carbon atoms, was given as an intravenous bolus (800 μmol/kg of body weight [kg BW ]) in male Wistar rats to study its pharmacokinetic profile. Because total plasma C12, which results from the sum of both free and albumin binding fractions, was measured by high‐performance liquid chromatography, an in vitro experimental session was carried out to determine the binding curve of C12 in rat plasma. These data were then used to calculate the plasma C12 free fraction in in vivo experiments. The best fit obtained for the experimental data of albumin binding was obtained with the equation of reversible, saturable binding to one, two, or three classes of noninteracting equivalent sites. Only a single binding site was clearly identified with a dissociation constant of 147 μmol/L and a maximal predicted binding of 1.57 mol/mol albumin. The urinary excretion of C12 was 3.90 ± 1.62% of the administered dose. The pharmacokinetic analysis was performed by one‐compartment model with linear transfer to the tissues, taking into account simultaneously both plasma concentration and urine excretion data. The apparent volume of distribution of C12 was 0.248 ± 0.035 L/kg BW , the apparent first order rate constant to the tissues was 0.0535 ± 0.0123 min −1 and that from plasma to urine was 0.00206 ± 0.00051 min −1 . The C12 plasma half‐life was 12.47 minutes. Renal clearance was 0.00051 L/kg BW per minute, whereas the systemic clearance was 0.0138 L/kg BW per minute. Because the renal clearance was much less than the rat inulin clearance reported in literature, the presence of C12 passive back‐diffusion was hypothesized. ( Journal of Parenteral and Enteral Nutrition 18:225–230, 1994)
    Type of Medium: Online Resource
    ISSN: 0148-6071 , 1941-2444
    URL: Article
    DOI: 10.1177/0148607194018003225
    Language: English
    Publisher: Wiley
    Publication Date: 1994
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  • 7
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    Dicarboxylic Acids and Glucose Utilization in Humans: Effect of Sebacate
    Wiley ; 1994
    In:  Journal of Parenteral and Enteral Nutrition Vol. 18, No. 1 ( 1994-01), p. 9-13
    Details
    In: Journal of Parenteral and Enteral Nutrition, Wiley, Vol. 18, No. 1 ( 1994-01), p. 9-13
    Abstract: Dicarboxylic acids have been proposed as an alternate lipid energetic substrate for total parenteral nutrition. No data are yet available on the possible effect of dicarboxylic acids on glucose metabolism in humans. Thus, we examined the effect of a continuous intravenous infusion of the sodium salt of the10‐carbon atom alyphatic dicarboxylic acid, sebacate (Sb), on insulin‐dependent glucose metabolism in four control subjects, four patients with insulin‐dependent diabetes mellitus, and four obese subjects. All subjects received a constant 5‐hour infusion of saline or sebacate (6.6 g/h), in a randomized order on two different days. After 3 hours of infusion, a 120‐minute euglycemic, hyperinsulinemic clamp procedure was performed (insulin infusion rate = 40 mU/m 2 per minute). Glucose uptake, plasma sebacate, insulin, glucagon, C‐peptide, and ketone bodies were measured. No significant differences in insulinemia were found among groups either during the saline infusion or the sebacate infusion. On the contrary, glucose uptake (molar) was significantly reduced during the sebacate vs the saline day in all three groups: 6.7 ± 0.04 vs 3.7 ± 1.3 in control subjects ( p 〈 .001), 4.6 ± 0.4 vs 2.5 ± 1.2 in patients with insulin‐dependent diabetes mellitus ( p 〈 .001), and 4.8 ± 0.5 vs 2.7 ± 0.2 mg/kg per minute in obese subjects ( p 〈 .001). In conclusion, Sb administration was associated with a glucose‐sparing effect as shown by the reduced glucose uptake in all patients studied. Sebacate did not stimulate insulin secretion, inasmuch as no modification of C‐peptide plasma levels was observed after 3 hours of Sb infusion. In addition, no change in Sb steady‐state levels was observed during hyperinsulinemia, suggesting that insulin does not influence Sb plasma clearance. ( Journal of Parenteral and Enteral Nutrition 18 :9–13, 1994)
    Type of Medium: Online Resource
    ISSN: 0148-6071 , 1941-2444
    URL: Article
    DOI: 10.1177/014860719401800109
    Language: English
    Publisher: Wiley
    Publication Date: 1994
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  • 8
    Online Resource
    Online Resource
    Pharmocokinetics of dicarboxylic acids in man
    Institute of Electrical and Electronics Engineers (IEEE) ; 1994
    In:  IEEE Engineering in Medicine and Biology Magazine Vol. 13, No. 4 ( 1994-08), p. 472-478
    Details
    In: IEEE Engineering in Medicine and Biology Magazine, Institute of Electrical and Electronics Engineers (IEEE), Vol. 13, No. 4 ( 1994-08), p. 472-478
    Type of Medium: Online Resource
    ISSN: 0739-5175
    URL: Article
    DOI: 10.1109/51.310987
    RVK:
    XA 48664
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 1994
    detail.hit.zdb_id: 2028871-2
    SSG: 12
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  • 9
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    Online Resource
    A glucagon-secretin-like peptide stimulates the intrinsic nervous plexus of guinea pig gallbladder
    Springer Science and Business Media LLC ; 1990
    In:  Experientia Vol. 46, No. 5 ( 1990-5), p. 452-454
    Details
    In: Experientia, Springer Science and Business Media LLC, Vol. 46, No. 5 ( 1990-5), p. 452-454
    Type of Medium: Online Resource
    ISSN: 0014-4754 , 1420-9071
    URL: Article
    DOI: 10.1007/BF01954226
    RVK:
    TA 1000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 1990
    detail.hit.zdb_id: 1458497-9
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  • 10
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    Online Resource
    Glucose-induced thermogenesis in postobese women who have undergone biliopancreatic diversion
    Elsevier BV ; 1994
    In:  The American Journal of Clinical Nutrition Vol. 60, No. 3 ( 1994-09), p. 320-326
    Details
    In: The American Journal of Clinical Nutrition, Elsevier BV, Vol. 60, No. 3 ( 1994-09), p. 320-326
    Type of Medium: Online Resource
    ISSN: 0002-9165
    URL: Article
    DOI: 10.1093/ajcn/60.3.320
    RVK:
    XA 18600
    Language: English
    Publisher: Elsevier BV
    Publication Date: 1994
    detail.hit.zdb_id: 1496439-9
    SSG: 12
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