In:
Applied and Environmental Microbiology, American Society for Microbiology, Vol. 59, No. 7 ( 1993-07), p. 2029-2033
Abstract:
The semicontinuous and continuous production of pharmaceutically useful ergot peptides with immobilized Claviceps purpurea could be demonstrated. A key aspect was the presence of high concentrations of CaCl 2 (96.9 mM) to give marked prolongation of the productive phase, and cultivation in a bubble column reactor became possible. Restriction of the phosphate supply avoided an otherwise problematic massive increase of outgrowing hyphae.
Type of Medium:
Online Resource
ISSN:
0099-2240
,
1098-5336
DOI:
10.1128/aem.59.7.2029-2033.1993
Language:
English
Publisher:
American Society for Microbiology
Publication Date:
1993
detail.hit.zdb_id:
223011-2
detail.hit.zdb_id:
1478346-0
SSG:
12
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