In:
International Archives of Allergy and Immunology, S. Karger AG, Vol. 92, No. 3 ( 1990), p. 209-216
Abstract:
Homologous passive cutaneous anaphylaxis (PCA) was induced by IgE antibody and, simultaneously, cutaneous reactions were induced by some allergic mediators such as histamine, serotonin and leukotriene (LT) C 〈 sub 〉 4 〈 /sub 〉 on rat back skin. Disodium cromoglycate and tranilast with inhibitory actions on mediator release inhibited PCA specifically, whereas antihistaminics, including ketotifen, azelastine, mequitazine and diphenhydramine, inhibited histamine- and serotonin-induced cutaneous reactions as well as PCA. Anti-slow-reacting substance of anaphylaxis drugs, KC-404 and FPL-55712, significantly inhibited PCA and histamine-and serotonin-induced reactions, but at the same doses they did not produce significant inhibition of the LTC 〈 sub 〉 4 〈 /sub 〉 -induced reaction. All reactions tested were strongly inhibited dose dependently with the β stimulants, salbutamol and isoproterenol, and a xanthine derivative, theophylline, which are known to increase the intra-cellular cyclic AMP level. We think that this method enables the determination of the properties of anti-allergic drugs.
Type of Medium:
Online Resource
ISSN:
1018-2438
,
1423-0097
Language:
English
Publisher:
S. Karger AG
Publication Date:
1990
detail.hit.zdb_id:
1482722-0
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