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  • 1990-1994  (173)
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  • 1990-1994  (173)
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  • 1
    Online Resource
    Online Resource
    Abstract of the 68th Meeting (Spring Meeting) 6–9 March 1990, Heidelberg
    Springer Science and Business Media LLC ; 1990
    In:  Pflügers Archiv Vol. 415, No. 1 ( 1990-12), p. R1-R119
    Details
    In: Pflügers Archiv, Springer Science and Business Media LLC, Vol. 415, No. 1 ( 1990-12), p. R1-R119
    Type of Medium: Online Resource
    ISSN: 0031-6768 , 1432-2013
    URL: Article
    DOI: 10.1007/BF02912664
    RVK:
    WA 15000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 1990
    detail.hit.zdb_id: 1463014-X
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Measurement of the mass of the τ lepton
    American Physical Society (APS) ; 1992
    In:  Physical Review Letters Vol. 69, No. 21 ( 1992-11-23), p. 3021-3024
    Details
    In: Physical Review Letters, American Physical Society (APS), Vol. 69, No. 21 ( 1992-11-23), p. 3021-3024
    Type of Medium: Online Resource
    ISSN: 0031-9007
    URL: Article
    DOI: 10.1103/PhysRevLett.69.3021
    RVK:
    UA 1000
    RVK:
    UA 6520
    Language: English
    Publisher: American Physical Society (APS)
    Publication Date: 1992
    detail.hit.zdb_id: 1472655-5
    detail.hit.zdb_id: 208853-8
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  • 3
    Online Resource
    Online Resource
    A Placebo-Controlled Clinical Trial of Prednisone in the Treatment of Early Hemorrhagic Fever
    Oxford University Press (OUP) ; 1990
    In:  Journal of Infectious Diseases Vol. 162, No. 5 ( 1990-11-01), p. 1213-1214
    Details
    In: Journal of Infectious Diseases, Oxford University Press (OUP), Vol. 162, No. 5 ( 1990-11-01), p. 1213-1214
    Type of Medium: Online Resource
    ISSN: 0022-1899 , 1537-6613
    URL: Article
    DOI: 10.1093/infdis/162.5.1213
    RVK:
    XA 10000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 1990
    detail.hit.zdb_id: 1473843-0
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  • 4
    Online Resource
    Online Resource
    IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha.
    The American Association of Immunologists ; 1991
    In:  The Journal of Immunology Vol. 147, No. 9 ( 1991-11-01), p. 2964-2969
    Details
    In: The Journal of Immunology, The American Association of Immunologists, Vol. 147, No. 9 ( 1991-11-01), p. 2964-2969
    Abstract: IL-1 converting enzyme (ICE) specifically cleaves the human IL-1 beta precursor at two sequence-related sites: Asp27-Gly28 (site 1) and Asp116-Ala117 (site 2). Cleavage at Asp116-Ala117 results in the generation of mature, biologically active IL-1 beta. ICE is unusual in that preferred cleavage at Asp-X bonds (where X is a small hydrophobic residue), has not been described for any other eukaryotic protease. To further examine the substrate specificity of ICE, proteins that contain Asp-X linkages including transferrin, actin, complement factor 9, the murine IL-1 beta precursor, and human and murine IL-1 alpha precursors, were assayed for cleavage by 500-fold purified ICE. The human and murine IL-1 beta precursors were the only proteins cleaved by ICE, demonstrating that ICE is an IL-1 beta convertase. Analysis of human IL-1 beta precursor mutants containing amino acid substitutions or deletions within each processing site demonstrated that omission or replacement of Asp at site 1 or site 2 prevented cleavage by ICE. To quantitatively assess the substrate requirements of ICE, a peptide-based cleavage assay was established using a 14-mer spanning site 2. Cleavage between Asp [P1] and Ala [P1'] 2 was demonstrated. Replacement of Asp with Ala, Glu, or Asn resulted in a greater than 100-fold reduction in cleavage activity. The rank order in position P1' was Gly greater than Ala much greater than Leu greater than Lys greater than Glu. Substitutions at P2'-P4' and P6' had relatively little effect on cleavage activity. These results show that ICE is a highly specific IL-1 beta convertase with absolute requirements for Asp in P1 and a small hydrophobic amino acid in P1'.
    Type of Medium: Online Resource
    ISSN: 0022-1767 , 1550-6606
    URL: Article
    DOI: 10.4049/jimmunol.147.9.2964
    RVK:
    XA 54100
    RVK:
    XA 10000
    Language: English
    Publisher: The American Association of Immunologists
    Publication Date: 1991
    detail.hit.zdb_id: 1475085-5
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  • 5
    Online Resource
    Online Resource
    Purification and characterization of recombinant human farnesyl diphosphate synthase expressed in Escherichia coli
    Portland Press Ltd. ; 1991
    In:  Biochemical Journal Vol. 275, No. 1 ( 1991-04-01), p. 61-65
    Details
    In: Biochemical Journal, Portland Press Ltd., Vol. 275, No. 1 ( 1991-04-01), p. 61-65
    Abstract: We previously reported the isolation of a partial-length human fetal-liver cDNA encoding farnesyl diphosphate (FPP) synthase (EC 2.5.1.10) and the expression of an active FPP synthase fusion protein in Escherichia coli. The expressed human FPP synthase fusion protein has now been purified to apparent homogeneity by using two chromatographic steps. The purification scheme allowed the preparation of 1.8 mg of homogeneous protein from 149 mg of crude extract in a 64% yield with a 52-fold enrichment. A single band with a subunit molecular mass of 39 kDa was observed by Coomassie Blue staining after SDS/PAGE. A molecular mass of 78-80 kDa was calculated for the native form of the fusion protein by h.p.l.c. on a SEC-250 column, suggesting that the active fusion protein is a dimer. The purified fusion protein has FPP synthase condensation activities in the presence of both substrates, isopentenyl diphosphate and geranyl diphosphate. Enzyme activity was inhibited by a bisubstrate analogue of isopentenyl diphosphate and dimethylallyl diphosphate, and a small amount of higher prenyltransferase was observed. Michaelis constants for isopentenyl diphosphate and geranyl diphosphate were 0.55 and 0.43 microM respectively, and Vmax for synthesis of farnesyl diphosphate from these substrates was 1.08 mumol/min per mg. These results suggest that the structure and catalytic properties of the expressed FPP synthase fusion protein are virtually identical with those of the native human liver enzyme.
    Type of Medium: Online Resource
    ISSN: 0264-6021 , 1470-8728
    URL: Article
    DOI: 10.1042/bj2750061
    RVK:
    WA 15000
    Language: English
    Publisher: Portland Press Ltd.
    Publication Date: 1991
    detail.hit.zdb_id: 1473095-9
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Multiphoton ionization of uranium hexafluoride
    AIP Publishing ; 1994
    In:  The Journal of Chemical Physics Vol. 100, No. 1 ( 1994-01-01), p. 28-43
    Details
    In: The Journal of Chemical Physics, AIP Publishing, Vol. 100, No. 1 ( 1994-01-01), p. 28-43
    Abstract: Multiphoton ionization (MPI) time-of-flight mass spectroscopy (TOFMS) and photoelectron spectroscopy (PES) studies of UF6 are reported using focused light from the Nd:YAG laser fundamental (λ=1064 nm) and its harmonics (λ=532, 355, or 266 nm), as well as other wavelengths provided by a tunable dye laser. The MPI mass spectra are dominated by the singly and multiply charged uranium ions rather than by the UF+x fragment ions, even at the lowest laser power densities at which signal could be detected. In general, the doubly charged uranium ion (U2+) intensity is much greater than that of the singly charged uranium ion (U+). For the case of the tunable dye laser experiments, the Un+ (n=1–4) wavelength dependence is relatively unstructured and does not show observable resonance enhancement at known atomic uranium excitation wavelengths. The MPI-PES studies reveal only very slow electrons (≤0.5 eV) for all wavelengths investigated. The dominance of the U2+ ion, the absence or very small intensities of UF+x (x=1–3) fragments, the unstructured wavelength dependence, and the preponderance of slow electrons all indicate that mechanisms may exist other than ionization of bare U atoms following the stepwise photodissociation of F atoms from the parent molecule. The data also argue against stepwise photodissociation of UF+x (x=5,6) ions. Neither of the traditional MPI mechanisms (‘‘neutral ladder’’ or the ‘‘ionic ladder’’) are believed to adequately describe the ionization phenomena observed. We propose that the multiphoton excitation of UF6 under these experimental conditions results in a highly excited molecule, superexcited UF6**. The excitation of highly excited UF6** is proposed to be facilitated by the well known ‘‘giant resonance,’’ whose energy level lies in the range of 12–14 eV above that of ground state UF6. The highly excited molecule then primarily dissociates, via multiple channels, into Un+, UF+x, fluorine atoms, and ‘‘slow’’ electrons, although dissociation into F− ions is not ruled out.
    Type of Medium: Online Resource
    ISSN: 0021-9606 , 1089-7690
    URL: Article
    DOI: 10.1063/1.467270
    Language: English
    Publisher: AIP Publishing
    Publication Date: 1994
    detail.hit.zdb_id: 3113-6
    detail.hit.zdb_id: 1473050-9
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  • 7
    Online Resource
    Online Resource
    Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus
    Springer Science and Business Media LLC ; 1994
    In:  Nature Genetics Vol. 8, No. 1 ( 1994-9), p. 22-26
    Details
    In: Nature Genetics, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 1994-9), p. 22-26
    Type of Medium: Online Resource
    ISSN: 1061-4036 , 1546-1718
    URL: Article
    DOI: 10.1038/ng0994-22
    RVK:
    XA 10000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 1994
    detail.hit.zdb_id: 1494946-5
    SSG: 12
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    Online Resource
  • 8
    Online Resource
    Online Resource
    Activation analysis in a multitechnique study of trace element imbalances in age-related neurological diseases
    Springer Science and Business Media LLC ; 1993
    In:  Journal of Radioanalytical and Nuclear Chemistry Articles Vol. 168, No. 1 ( 1993-2), p. 223-231
    Details
    In: Journal of Radioanalytical and Nuclear Chemistry Articles, Springer Science and Business Media LLC, Vol. 168, No. 1 ( 1993-2), p. 223-231
    Type of Medium: Online Resource
    ISSN: 0236-5731 , 1588-2780
    URL: Article
    DOI: 10.1007/BF02040894
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 1993
    detail.hit.zdb_id: 2017242-4
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  • 9
    Online Resource
    Online Resource
    Particle simulations of driven collisionless magnetic reconnection at the dayside magnetopause
    American Geophysical Union (AGU) ; 1992
    In:  Journal of Geophysical Research: Space Physics Vol. 97, No. A6 ( 1992-06), p. 8453-8481
    Details
    In: Journal of Geophysical Research: Space Physics, American Geophysical Union (AGU), Vol. 97, No. A6 ( 1992-06), p. 8453-8481
    Abstract: Basic plasma processes associated with driven collisionless magnetic reconnection at the Earth's dayside magnetopause are studied on the basis of particle simulations. A two‐and‐one‐half‐dimensional (2½‐D) electromagnetic particle simulation model with a driven inflow boundary and an open outflow boundary is developed for the present study. The driven inflow boundary is featured with a driving electric field for the vector potential, while the open outflow boundary is characterized by a vacuum force‐free condition for the electrostatic potential. The major findings are as follows: (1) the simulations exhibit both quasi‐steady single X line reconnection and intermittent multiple X line reconnection (MXR); the MXR process is characterized by repeated formation and convection of magnetic islands; (2) particle acceleration in the reconnection process results in a power law energy spectrum of ƒ( E ) ∼ E −4 for energetic ions with E 〉 40 keV and energetic electrons with E 〉 3 keV, where E is the particle energy; particles are accelerated to high energy near magnetic O line regions as particles are trapped within magnetic islands; (3) field‐aligned particle heat fluxes and intense plasma waves associated with the collisionless magnetic reconnection process are also observed; typical power spectra of fluctuating magnetic and electric fields are found to be P B ∼ f −3.6 and P E ∼ f −1.8 , respectively, where f is the wave frequency; (4) when applied to the dayside magnetopause, simulation results show that the MXR process tends to generate a simultaneous magnetic field perturbation on both sides of the dayside magnetopause, resembling the observed features of two‐regime flux transfer events (FTEs); and (5) an intrusion of magnetosheath plasma bulge into the magnetosphere due to the formation of magnetic islands may lead to the layered structures observed in magnetospheric FTEs. Simulation results are applied to the dayside magnetopause to provide an explanation for some features associated with dayside magnetic reconnection and FTEs.
    Type of Medium: Online Resource
    ISSN: 0148-0227
    URL: Article
    DOI: 10.1029/92JA00304
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 1992
    detail.hit.zdb_id: 2033040-6
    detail.hit.zdb_id: 3094104-0
    detail.hit.zdb_id: 2130824-X
    detail.hit.zdb_id: 2016813-5
    detail.hit.zdb_id: 2016810-X
    detail.hit.zdb_id: 2403298-0
    detail.hit.zdb_id: 2016800-7
    detail.hit.zdb_id: 161666-3
    detail.hit.zdb_id: 161667-5
    detail.hit.zdb_id: 2969341-X
    detail.hit.zdb_id: 161665-1
    detail.hit.zdb_id: 3094268-8
    detail.hit.zdb_id: 710256-2
    detail.hit.zdb_id: 2016804-4
    detail.hit.zdb_id: 3094181-7
    detail.hit.zdb_id: 3094219-6
    detail.hit.zdb_id: 3094167-2
    detail.hit.zdb_id: 2220777-6
    detail.hit.zdb_id: 3094197-0
    SSG: 16,13
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  • 10
    Online Resource
    Online Resource
    Dynamic Hsp83 RNA localization during Drosophila oogenesis and embryogenesis.
    Informa UK Limited ; 1993
    In:  Molecular and Cellular Biology Vol. 13, No. 6 ( 1993-06), p. 3773-3781
    Details
    In: Molecular and Cellular Biology, Informa UK Limited, Vol. 13, No. 6 ( 1993-06), p. 3773-3781
    Abstract: Hsp83 is the Drosophila homolog of the mammalian Hsp90 family of regulatory molecular chaperones. We show that maternally synthesized Hsp83 transcripts are localized to the posterior pole of the early Drosophila embryo by a novel mechanism involving a combination of generalized RNA degradation and local protection at the posterior. This protection of Hsp83 RNA occurs in wild-type embryos and embryos produced by females carrying the maternal effect mutations nanos and pumilio, which eliminate components of the posterior polar plasm without disrupting polar granule integrity. In contrast, Hsp83 RNA is not protected at the posterior pole of embryos produced by females carrying maternal mutations that disrupt the posterior polar plasm and the polar granules--cappuccino, oskar, spire, staufen, tudor, valois, and vasa. Mislocalization of oskar RNA to the anterior pole, which has been shown to result in induction of germ cells at the anterior, leads to anterior protection of maternal Hsp83 RNA. These results suggest that Hsp83 RNA is a component of the posterior polar plasm that might be associated with polar granules. In addition, we show that zygotic expression of Hsp83 commences in the anterior third of the embryo at the syncytial blastoderm stage and is regulated by the anterior morphogen, bicoid. We consider the possible developmental significance of this complex control of Hsp83 transcript distribution.
    Type of Medium: Online Resource
    ISSN: 0270-7306 , 1098-5549
    URL: Article
    DOI: 10.1128/MCB.13.6.3773
    RVK:
    WA 15000
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 1993
    detail.hit.zdb_id: 1474919-1
    SSG: 12
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