In:
Tumori Journal, SAGE Publications, Vol. 78, No. 1 ( 1992-02), p. 1-4
Abstract:
The production and characterization of two new monoclonal antibodies (MAbs), designated MAR4 and MAR5, raised against the partially purified α 5 β 1 integrin, are described. The reactivity of these 2 MAbs on tumor cell lines indicated that they reacted on all the cells expressing the β 1 subunit independently of the α 5 expression. Both MAbs were found to immunoprecipitate on 3 cell lines, a protein of 120 KD corresponding to the molecular weight be the β 1 chain, in addition to proteins of other MW corresponding to the α subunits differentially expressed by these cells. The cross-competition experiments showed that MAR4 and MAR5 recognize the same epitope. These 2 MAbs seem to be useful reagents for the characterization of the VLA expression in tumor cells.
Type of Medium:
Online Resource
ISSN:
0300-8916
,
2038-2529
DOI:
10.1177/030089169207800101
Language:
English
Publisher:
SAGE Publications
Publication Date:
1992
detail.hit.zdb_id:
280962-X
detail.hit.zdb_id:
2267832-3
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