In:
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 38, No. 5 ( 1994-05), p. 1209-1210
Abstract:
The penetration of ceftriaxone into cerebrospinal fluid (CSF) was studied with 11 children (mean age: 2 years, 4 months; range: 4 months to 8 years) with meningitis, receiving dexamethasone (0.15 mg/kg of body weight intravenously four times daily) as adjunctive therapy. Ceftriaxone was given intravenously at doses of 50 mg/kg twice daily to patients 〈 18 months old and 100 mg/kg once daily to patients 〉 or = 18 months old. CSF was collected after 1 day of treatment at the expected peak concentration of ceftriaxone in CSF. Concentrations of ceftriaxone in CSF ranged from 0.7 to 9.2 mg/liter, with a mean value of 4.0 (standard deviation [SD], 2.9) mg/liter. Values were significantly higher for patients with CSF glucose levels of 〈 1 mmol/liter on admission to the hospital than for patients with CSF glucose levels of 〉 or = 1 mmol/liter (mean values of 7.1 [SD, 2.2] mg/liter versus 2.2 [SD, 1.1] mg/liter; P 〈 0.001). After 1 day of treatment, ceftriaxone concentrations in the CSF of children receiving dexamethasone are similar to the mean values reported for children not treated with dexamethasone.
Type of Medium:
Online Resource
ISSN:
0066-4804
,
1098-6596
DOI:
10.1128/AAC.38.5.1209
Language:
English
Publisher:
American Society for Microbiology
Publication Date:
1994
detail.hit.zdb_id:
1496156-8
SSG:
12
SSG:
15,3
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