ISSN:
1573-7217
Keywords:
breast cancer
;
gonadotropin-releasing hormone-analog
;
GnRH
;
receptor
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Gonadotropin-releasing hormone analogs (GnRH-A) have been added to the armentarium in the therapy of hormone-dependent breast cancer in premenopausal women. The effect of chronic GnRH-A-treatment in premenopausal women is based on the suppression of the hypothalamus-pituitary-ovarian axis and the reduction of sex-steroid serum levels. In addition, a number of experimental and clinical data have been accumulated indicating a direct action of GnRH-A on breast cancer cells and tissue. In this study we analyzed 235 human breast cancer biopsies for specific GnRH-A-binding. We demonstrate high affinity GnRH-A binding sites in human breast cancer tissues. The evaluation of clinical data showed no correlation of the level of GnRH-A-binding with classical tumor parameters.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00662399
Permalink