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  • 1
    Electronic Resource
    Electronic Resource
    The eutrophic Loosdrecht Lakes: Current ecological research and restoration perspectives (1986)
    Springer
    Aquatic ecology 20 (1986), S. 61-75 
    Details
    ISSN: 1573-5125
    Keywords: eutrophication ; lake restoration ; blue-green algae ; zooplankton ; seston ; epipelon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Features of the Loodsrecht Lakes, with emphasis on the main lake, are discussed with reference to restoration. Characteristics of the present situation are: (1) very low water transparency-Secchi-disc readings around 0.3 m occur in all seasons; (2) relatively small seasonal changes in sestonic matter; (3) important input of resuspended particles into the seston; (4) predominance of filamentous blue-green algae for most of the year; (5) relative scarcity of crustacean zooplankton, while rotifers are abundant; (6) poor development of littoral communities, and absence of benthic producers. The blue-green algae maintain high population density at very low growth rates: rates of loss are low. The zooplankton grazing rate is low due to inefficient filtering, but predation of larger crustaceans by fish may also be important. Studies on epipelon indicated that loss by deposition may be largely compensated by resuspension. Starting in 1984, the external phosphorus loading was markedly reduced. Results for 1984 and 1985 indicate that complementary measures are needed in order to improve water quality. Action should be directed towards increasing the phytoplankton turnover rates. Accelerated specific growth rate can be expected to accompany lower biomass, more successful competition by other algal groups, and enhancement of grazing pressure. Considering the shallowness of the system, promotion of littoral development and return of submerged vegetation may be important in establishing a new equilibrium of the system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02291151
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  • 2
    Electronic Resource
    Electronic Resource
    Progress in the research of artemisinin-related antimalarials: An update (1994)
    Springer
    Pharmacy world & science 16 (1994), S. 169-180 
    Details
    ISSN: 1573-739X
    Keywords: Antimalarials ; Artemisia annua L ; Artemisinin ; Biosynthesis ; Chemistry ; Clinical trials ; Pharmacology ; Phytochemistry ; Sesquiterpenes ; Toxicology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Artemisinin, a sesquiterpene lactone endoperoxide isolated fromArtemisia annua L., and a number of its semisynthetic derivatives have shown to possess antimalarial properties. They are all eflective againstPlasmodium parasites that are resistant to the newest and commonly used antimalarial drugs. This article gives a survey of the literature dealing with artemisinin-relaled antimalarial issues that have appeared from the end of 1989 up to the beginning of 1994. A broad range of medical and pharmaceutical disciplines is covered, including phytochemical aspects like the selection of high-producing plants, analytical procedures, and plant biotechnology. Furthermore, the organic synthesis of artemisinin derivatives is discussed, as well as their mechanism of action and antimalarial activity, metabolism and pharmacokinetics, clinical studies, sideeffects and toxicology, and biological activities other than antimalarial activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01872865
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  • 3
    Electronic Resource
    Electronic Resource
    Coupling of phytoplankton and detritus in a shallow, eutrophic lake (Lake Loosdrecht, The Netherlands) (1992)
    Springer
    Hydrobiologia 233 (1992), S. 51-59 
    Details
    ISSN: 1573-5117
    Keywords: phytoplankton ; Oscillatoria limnetica ; Prochlorothrix hollandica ; detritus ; shallow lakes ; lake restoration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract An oscillating steady state is described of phytoplankton, dominated by Prochlorothrix hollandica and Oscillatoria limnetica, and sestonic detritus in shallow, eutrophic Lake Loosdrecht (The Netherlands). A steady-state model for the coupling of the phytoplankton and detritus is discussed in relation to field and experimental data on phytoplankton growth and decomposition. According to model predictions, the phytoplankton to detritus ratio decreases hyperbolically at increasing phytoplankton growth rate and is independent of a lake's trophic state. The seston in L. Loosdrecht contains more detritus than phytoplankton as will apply to many other lakes. The model provides a basis for estimating the loss rate of the detritus, including decomposition, sedimentation and hydraulic loss. In a shallow lake like L. Loosdrecht detritus will continue to influence the water quality for years.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00016095
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  • 4
    Electronic Resource
    Electronic Resource
    Dynamics of phytoplankton detritus in a shallow, eutrophic lake (Lake Loosdrecht, The Netherlands) (1992)
    Springer
    Hydrobiologia 233 (1992), S. 61-67 
    Details
    ISSN: 1573-5117
    Keywords: phytoplankton ; epipelon ; Oscillatoria limnetica ; detritus ; shallow lakes ; lake restoration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A study was made of the mortality and aerobic decomposition of light- and phosphorus-limited cultures of Oscillatoria limnetica, a dominant phytoplankton species in shallow, eutrophic Lake Loosdrecht (The Netherlands). When placed in the dark at 20 °C, most cells died and lysed within twelve days. The labile organic matter was completely decomposed within three weeks. Absorbance spectra indicated that blue green algae may contributed significantly to the refractory dissolved substances in the lake. Refractory particulate matter constituted from 7 to 24% of the biomass of O. limnetica, depending on the growth rate before incubation in the dark. The decomposition rate of this fraction was 0.005 d−1. On a basis of a steady-state model of the dynamics of phytoplankton detritus, the areal organic dry weight concentration of the detritus in the lake is ca. 60 g m−2. This means the quantities of detritus in the seston and epipelon are about equal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00016096
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  • 5
    Electronic Resource
    Electronic Resource
    Dielectric properties of hydrated collagen (1979)
    New York : Wiley-Blackwell
    Biopolymers 18 (1979), S. 35-45 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Dielectric measurements have been carried out on partially hydrated collagen in the frequency ranges 100 kHz-5 MHz, 100 MHz-1 GHz, and 8-23 GHz. In the low-frequency range, a dispersion was observed around 100 kHz which results from inhomogeneous conductivity of the samples. A dielectric relaxation was observed aroud 0.3 GHz using time-domain-spectroscopy techniques. This relaxation can be considered to originate from mobile side chains. Microwave measurements indicate that the water relaxation may extend into the 10-GHz region. An apparent discrepancy between the main water relaxation time and the average rotational correlation time of water as measured by nmr line widths was resolved by the assumption that a fraction of the water molecules is bound to the collagen with residence times on the order of 10-6 sec, whereas the remainder of the water is only weakly bound and exhibits rotational rates on the order of 10-10 sec.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.1979.360180105
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  • 6
    Electronic Resource
    Electronic Resource
    Molecular dynamics simulation of the stability of a 22-residue α-helix in water and 30% trifluoroethanol (1993)
    New York : Wiley-Blackwell
    Biopolymers 33 (1993), S. 1159-1166 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A molecular dynamics (MD) simulation was performed on the α-helix H8-HC5, the C-terminal part of myoglobin (residue 132-153), under periodic boundary conditions in two different solutions, water and water with 30% (v/v) 2,2,2-trifluoroethanol (TFE), at 300 K to investigate the stability of the helix. In both simulations, the initial configuration was a canonical right-handed α-helix. In the course of the MD trajectory in water (200 ps), the helix clearly destabilized and began to unfold after 100 ps. In the TFE solution, two stable parts of helical regions were observed after 70 ps of a 200-ps MD simulation, supporting the notion that TFE acts as a structure-forming solvent. © 1993 John Wiley & Sons, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360330802
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  • 7
    Electronic Resource
    Electronic Resource
    Water Relaxation Measurements on Semiquinones of Various Flavoproteins (1982)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 65 (1982), S. 2422-2430 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The water relaxation rates of several flavoproteins in the semiquinone state have been investigated by the spin echo technique. The results indicate a rather unspecific interaction between water and the protein-bound flavosemiquinones. An average interaction distance of 0.3-0.5 nm has been estimated. From the temperature dependence of the rate constants the free energy of activation for proton exchange is calculated to be about 17 kJ/mol. The rate of proton exchange is around 1011 s-1 for the flavosemiquinones investigated are accessible to water regardless of their ionic state.The large difference in relaxation rates of water protons between D- and L- amino-acid oxidases is noticeable. Oxynitrilase exhibits the highest whereas Azotobacter vinelandii flavodoxin shows the lowest water relaxation rate of the flavoproteins studied. The results are discussed in relation to the visible-light absorption properties of the flavoproteins.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19820650807
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  • 8
    Electronic Resource
    Electronic Resource
    The chemistry of drugs part IVPart III, see [1]., Configurations of antimalarials derived from qinghaosu: Dihydroqingyhaosu, artemether, and artesunic acid (1984)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 67 (1984), S. 1515-1522 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The structures of the antimalarials dihydroqinghaosu (2), artemether (3), and artesunic acid (7a) derived from qinghaosu were elaborated by 1H-NMR spectroscopy, and supported with X-ray data obtained for 2 and 3. Several new derivatives, useful for the chemical characterization of dihydroqinghaosu (2) and artesunic acid (7a), were prepared.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19840670615
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  • 9
    Electronic Resource
    Electronic Resource
    Detection of nanoscale events in dispersed polymer particles containing a charge-transfer fluorescence probe (1995)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 33 (1995), S. 399-405 
    Details
    ISSN: 0887-624X
    Keywords: polystyrene latex ; fluorescence ; solvent diffusion ; staining ; fluorescent probe ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A probe molecule, which shows an unusually large change in fluorescent properties in response to changes in its environment, was introduced into a monodisperse polystyrene latex. Upon addition of low-molecular-weight compounds, the ensuing swelling process of the latex could be followed via the changes in the fluorescence spectrum of the probe molecule. Polymerization reactions of monomers, introduced into the particles, could also be monitored by means of this approach. Using glycidylmethacrylate as the monomer led to the formation of particles in which two distinctly different surroundings could be detected after such a polymerization. © 1995 John Wiley & Sons, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1995.080330307
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  • 10
    Electronic Resource
    Electronic Resource
    Molecular dynamics simulation of the docking of substrates to proteins (1994)
    New York, NY : Wiley-Blackwell
    Proteins: Structure, Function, and Genetics 19 (1994), S. 174-182 
    Details
    ISSN: 0887-3585
    Keywords: molecular dynamics ; docking ; computer simulation ; substrate docking ; immunoglobulin ; rational drug design ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: A simple method is described to perform docking of subtrates to proteins or probes to receptor molecules by a modification of molecular dynamics simulations. The method consists of a separation of the center-of-mass motion of the substrate from its internal and rotational motions, and a separate coupling to different thermal baths for both types of motion of the substrate and for the motion of the receptor. Thus the temperatures and the time constants of coupling to the baths can be arbitrarily varied for these three types of motion, allowing either a frozen or a flexible receptor and allowing control of search rate without disturbance of internal structure. In addition, an extra repulsive term between substrate and protein was applied to smooth the interaction. The method was applied to a model substrate docking onto a model surface, and to the docking of phosphocholine onto immunoglobulin McPC603, in both cases with a frozen receptor. Using transrational temperatures of the substrate in the range of 1300-1700 K and room temperature for the internal degrees of freedom of the substrate, an efficient nontrapping exploratory search (“helicopter view”) is obtained, which visits the correct binding sites. Low energy conformations can then be further investigated by separate search or by dynamic simulated annealing. In both cases the correct minima were identified. The possibility to work with flexible receptors is discussed. © 1994 Wiley-Liss, Inc.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prot.340190303
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