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  • 1
    Electronic Resource
    Electronic Resource
    Microspectrophotometry ofEuglena gracilis (1990)
    Springer
    Planta 182 (1990), S. 375-381 
    Details
    ISSN: 1432-2048
    Keywords: Euglena (microspectrophotometry) ; Flavin Near-UV/blue-light photoreceptor ; Paraflagellar body ; Photoreceptor (near UV/blue light) ; Pterin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The paraflagellar bodies (PFBs) of isolated flagella ofEuglena gracilis were investigated microspectrophotometrically using a visible- and infrared-light microscope with image analyzer and microspectrophotometer. Flagella with attached PFBs were separated from the cell bodies by a short exposure to near-UV light. Fluorescence-emission spectra (excitation at 365 nm) of single PFBs had maxima near 470 and 520 nm, indicating the presence of pterins and flavins. No fluorescence was associated with the flagella themselves. Pterin- and flavin-like fluorescence emission was also found in blue-fluorescing vesicles distributed throughout the entire cell body ofEuglena. Their characterization by microfluorimetry was greatly aided by the use of chlorophyll-free mutants in which the signal-to-noise ratio was distinctly enhanced because of the lack of chlorophyll fluorescence. Our finding of flavin-like fluorescence associated with PFB strengthens similar earlier reports in the literature. The occurrence of pterin-like fluorescence in the PFB lends further support to our earlier proposal that pterins as well as flavins may function as photoreceptor pigments for near-UV and blue light.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02411388
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The AMPA antagonists NBQX and GYKI 52466 do not counteract neuroleptic-induced catalepsy (1994)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 349 (1994), S. 61-65 
    Details
    ISSN: 1432-1912
    Keywords: AMPA receptor ; NBQX ; GYKI 52466 ; Dizocilpine ; Quinpirole ; l-DOPA ; Catalepsy ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The AMPA antagonists NBQX (2.5, 5, 10 mg/kg) and GYKI 52466 (4.8, 8 mg/kg) were investigated in haloperidol (0.5 mg/kg)-induced catalepsy in the rat. The effects of AMPA antagonists administered either alone or in combination with the noncompetitive NMDA antagonist dizocilpine (0.02 mg/kg), with the dopamine D-2 agonist quinpirole (1 mg/kg) or with L-DOPA (50, 100 mg/kg plus benserazide) were tested. NBQX or GYKI 52466 did not exert anticataleptic effects, neither alone nor in combination with dizocilpine, quinpirole or l-DOPA. Thus, in the rat inhibition of AMPA receptors with NBQX or GYKI 52466 does not have effects predictive for an antiparkinsonian potential.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00178207
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    Paper (German National Licenses)
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