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Hair cell regeneration in the bird cochlea following noise damage or ototoxic drug damage (1994)

Cotanche, Douglas A. ; Lee, Kenneth H. ; Stone, Jennifer S. ; [et al.]

Springer

Anatomy and embryology 189 (1994), S. 1-18

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ISSN: 1432-0568

Keywords: Hair cell ; Regeneration ; Avian ; Progenitor cells ; Basilar papilla

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Hair cells are sensory cells that transduce motion into neural signals. In the cochlea, they are used to detect sound waves in the environment and turn them into auditory signals that can be processed in the brain. Hair cells in the cochlea of birds and mammals were thought to be produced only during embryogenesis and, once made, they were expected to last throughout the lifetime of the animal. Thus, any loss of hair cells due to trauma or disease was thought to lead to permanent impairment of auditory function. Recently, however, studies from a number of laboratories have shown that hair cells in the avian cochlea can be regenerated after acoustic trauma or ototoxic drug damage. This regeneration is accompanied by a repair of the sensory organ and associated tissues and results in a recovery of auditory function. In this review, we examine and compare the structural events that lead to hair cell loss after noise damage and ototoxic drug damage as well as the processes involved in the recovery of the epithelium and the regeneration of the hair cells. Moreover, we examine functional recovery and how it relates to the structural recovery. Finally, we investigate the evidence for the hypothesis that supporting cells in the basilar papilla act as the progenitor cells for the regenerated hair cells and examine the cellular events required to stimulate the progenitor cells to leave the quiescent state, re-enter the cell cycle, and divide.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00193125

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Synthesis and Reactivity of Functionalized Dimethylsilyl Complexes of the Formula (η5-C5H5)Re(NO)(PPh3)(SiMe2X); New Base-Stabilized Silylene Complexes, Novel Lewis Acid Adducts, and Evidence for Base-Free Silylene Complexes (1991)

Lee, Kenneth E. ; Arif, Atta M. ; Gladysz, John A.

Weinheim : Wiley-Blackwell

Berichte der deutschen chemischen Gesellschaft 124 (1991), S. 309-320

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ISSN: 0009-2940

Keywords: Rhenium complexes ; Silylene complexes ; Chemistry ; Inorganic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Reactions of (η5-C5H5)Re(NO)(PPh3)(SiMe2H) (1) and CHCl3, CBr4, and CHI3 give halosilyl complexes (η5-C5H5)Re(NO)-(PPh3)(SiMe2X) [X = Cl (2), Br (3), I (4); 66-84%]. Addition of Me3SiOTf to 2 gives triflate (η5-C5H5)Re(NO)(PPh3)(SiMe2OTf) (5; 97%), which in turn reacts with (Me2N)3S⊕ [SiMe3F2]⊖ to give (η5-C5H5)Re(NO)(PPh3)(SiMe2F) (6; 77%). Reaction of 5 and pyridine gives the base-stabilized silylene complex [(η5-C5H5)Re(NO)(PPh3){SiMe2(NC5H5)}]⊕ TfO⊖ (7; 84%). CH2Cl2 solutions of (η5-C5H5)Re(NO)(PPh3)(CH3) (8) or 2 and Lewis acids are studied by IR and NMR. As assayed by IR, 8/ECl3 solutions (E = B, Al) show ReNO-ECl3 (major) and Re-ECl3 (minor) adducts. Solutions of 2/BCl3 show analogous adducts (-78°C), and in the presence of excess BCl3 (η5-C5H5)Re-(NO-BCl3)(PPh3)(SiMe2Cl) (11) crystallizes. Solutions of 2/AlCl3 show uncomplexed 2 and Re-AlCl3 (major) and ReNO-AlCl3 (minor) adducts. In contrast to 2-7 and 2/BCl3, 1H- and 13C-NMR spectra of 2/AlCl3 suggest an equilibrium with the base-free silylene complex [(η5-C5H5)Re(NO)(PPh3)-( = SiMe2)]⊕ X⊖.

Additional Material: 2 Ill.