ISSN:
1432-2013
Keywords:
Ca-channels
;
pancreatic ß-cell
;
Ba-currents
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Ba currents flowing through single Ca-channels were recorded from cell-attached patches on rat pancreatic ß-cells. Two types of voltage-activated Ca-channels were found. The first (T-type) had a single channel conductance of 8 pS in 100 mM Ba, was activated at a low threshold (around ±50mV) and inactivated by holding potentials positive to ±40 mV. These properties are similar to those described for T-type channels in other preparations. The second type of Ca-channel (L-type) had a single channel conductance of 20pS in 100 mM Ba, was activated at a higher threshold (〉 ±30mV), showed little inactivation during a 250 ms pulse and could be activated from a holding potential of ±40mV. The dihydropyridine agonist BAYK 8644 selectively prolonged L-type Ca-channel openings. These properties are characteristic of L-type Ca-channels.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00373633
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