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  • Springer  (4)
  • Köln : Universität zu Köln, Rechenzentrum
  • 1990-1994  (4)
Document type
Keywords
Publisher
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Changes of telomere lengths in human intracranial tumours (1993)
    Springer
    Human genetics 〈Berlin〉 91 (1993), S. 190-192 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The termini of human chromosomes comprise stretches of G-rich repeats that are about 5–20 kilobase (kb) in length. The size of the telomeres can be determined by hybridization with probes specific for these (ttaggg)n sequences after digestion of chromosomal DNA with appropriate restriction enzymes and electrophoretic separation of the fragments. Here, probing with the 32P-labelled synthetic (TTAGGG)3 oligonucleotide revealed length changes of the telomeres occurring in intracranial tumours. Among 60 samples analysed, 41.7% showed telomere elongation, and 21.7% telomere reduction, whereas 36.7% of the tumours exhibited equal lengths compared with the patients' peripheral blood leukocytes. Most of the elongated glioma telomeres exceeded in length those of untransformed astrocytes derived from human fetal tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222724
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Selected di- and tetranucleotide microsatellites from chromosomes 7, 12, 14, and Y in various Eurasian populations (1994)
    Springer
    Human genetics 〈Berlin〉 93 (1994), S. 592-596 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Microsatellite polymorphisms of nine Eurasian populations (〉1200 chromosomes) were analyzed for the following loci: i) intronic (gt) n stretches of three T cell receptor (TCR) B loci on chromosome 7 (TCRBV6S1, TCRBV6S3, TCRBV6S7); ii) an intergenic (gt) n repeat in the region between the TCRDV3 and TCRAJ61 elements on chromosome 14; iii) two tetranucleotide simple repeats (D12S66, D12S67), not linked to known genes on chromosome 12; iv) a Y-chromosomal (gata) n polymorphism (DYS19). In general, allele frequencies and heterozygosity rates were similar, but specific alleles were missing in one or more populations. Distinct DYS19 alleles predominated in particular cohorts. Different allele frequencies were observed for the TCR loci in European and Asian populations. Tetranucleotide polymorphisms were distributed normally, whereas TCR alleles displayed bimodal frequency profiles. For TCRBV6S1 and TCRBV6S7, this profile reflects a diallelic protein polymorphism that correlates exactly with the length of the intronic repeats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00202830
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Power and limits of DNA-profiling in primate populations: Paternity assessment in rhesus macaques from Cayo Santiago (1993)
    Springer
    Primates 34 (1993), S. 395-402 
    Details
    ISSN: 0032-8332
    Keywords: DNA fingerprinting ; Oligonucleotides ; Paternity assessment ; Heterozygosity ; Rhesus monkeys
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Paternity testing was performed in one social group (S) of rhesus macaques from Cayo Santiago, Puerto Rico. In 11/15 cases, sires could be identified comparing the multilocus DNA profiles of 19 males to those of the corresponding mother/child dyads. All 19 males could be excluded from paternity in the remaining four cases. Decision making was partly based on likelihoods of DNA profiles, and the theoretical model underlying these calculation is described. In a second social group (M), held in captivity, paternity testing was impeded by a deficit of maternal bands and by an increased extent of band sharing of mothers and their infants. Some possible explanations for these findings, including increased homozygosity in group M, are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02382635
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  • 4
    Electronic Resource
    Electronic Resource
    Male rank, reproductive behavior, and reproductive success in free-ranging rhesus macaques (1993)
    Springer
    Primates 34 (1993), S. 481-489 
    Details
    ISSN: 0032-8332
    Keywords: Macaca mulatta ; Cayo Santiago ; DNA fingerprinting ; Paternity ; Mating success ; Dominance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Paternity assessment through DNA fingerprinting by synthetic oligonucleotide probes was applied to one birth cohort in a social group of free-ranging rhesus macaques (Macaca mulatta) on Cayo Santiago. The 11 group males and 9 males from other groups were observed mating with the females. Paternity was determined for 11 of the 15 infants. Male dominance rank was not associated with reproductive success. High-ranking resident males (N=5) sired 27% of the infants born during a one-year study. Four of the 11 infants of known paternity were sired by males of other social groups. The four infants of unknown paternity were sired either by males not observed mating with the females or the low-ranking male who was not fingerprinted. Male dominance rank was not associated with reproductive activity during conception cycles. These results suggest that the effect of rank on male reproductive success is not a predictable correlation, but a conditional probability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02382659
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    Paper (German National Licenses)
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