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  • Chemistry  (14)
  • 31.30.Gs  (2)
  • Angiotensin II  (2)
  • 1990-1994  (17)
  • 1945-1949  (1)
  • 1
    ISSN: 1432-1440
    Keywords: Angiotensin II ; Insulin ; Smooth muscle cell ; Vascular
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hypertension has a high prevalence among subjects with decreased insulin sensitivity and/or hyperinsulinemia. Furthermore, angiotensin II plays a pivotal role in the regulation of vascular tone and is known to induce hypertrophy and/or hyperplasia in vascular smooth muscle cells. In the present study, the effect of insulin on angiotensin II induced smooth muscle cell growth (Wistar-Kyoto rat) was investigated. Cell growth was assessed by the measurement of [3H]thymidine incorporation into cell DNA. Insulin in a concentration range of 1.7 × 10−10–1.7 × 10−6 M lacked any effect on cell DNA synthesis. However, insulin enhanced the angiotensin 11 induced DNA synthesis in a concentration-dependent manner. This effect was similar in cells with a weak and in cells with a marked response in DNA synthesis to stimulation with 100 nM angiotensin 11. In conclusion, insulin is able to enhance angiotensin 11 induced DNA synthesis and may therefore function as a growth cofactor in vascular smooth muscle cells.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1440
    Keywords: Angiotensin II ; Diltiazem ; Mitogenic effect ; Nifedipine ; Platelet-derived growth factor ; Vascular smooth muscle cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Structural changes within the blood vessel wall such as hyperplasia and hypertrophy of vascular smooth muscle cells are important factors in the pathogenesis of hypertension. Humoral growth factors such as angiotensin II (AII) and platelet-derived growth factor BB (PDGF-BB) may participate in the remodelling of the blood vessel wall. Whether and by which mechanisms antihypertensive treatment is capable of influencing the structural blood vessel alterations to date remains unclear. In the present study, the effect of nifedipine and diltiazem on AII- and PDGF-BB-induced vascular smooth muscle cell proliferation was examined. Nifedipine and diltiazem at a concentration of 10 μM did not affect baseline DNA synthesis in isolated vascular smooth muscle cells in culture. AII (final concentration 100 nM) and PDGF-BB (50 ng/ml) stimulated DNA synthesis by approximately 9.0- and 4.6-fold, respectively. Both AII- and PDGF-BB-induced DNA synthesis was significantly blunted by diltiazem and nifedipine in a concentration of 10 μM, while no significant influence was seen with concentrations from 10 nM up to 1 μM. In contrast, no significant influence of these drugs could be observed on fetal calf serum 5%-induced DNA synthesis. The findings indicate that calcium antagonists possess antimitogenic potential and that they may thus contribute to the regression of structural changes of the blood vessels associated with hypertension.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Separation and Quantitation of All Eight Stereoisomers of α-Tocopherol by ChromatographyThe results of the analysis of several derivatives of (all-rac)-α-tocopherol by HPLC on a chiral stationary phase and by capillary GC on a achiral stationary phase are reported. Consecutive application of both methods to the ethyl-ether derivative allows the separation and quantification of all eight possible stereoisomers of (all-rac)-α-tocopherol.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 24 (1992), S. 161-164 
    ISSN: 1434-6079
    Keywords: 32.70.Jz ; 31.30.Gs ; 35.10.Bg
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The use of an effusive beam of titanium atoms crossed with a CW single-mode tunable dye laser has allowed the high-resolution, Doppler-free study of the isotope shifts between50Ti,48Ti and46Ti, for seven 3d 2 4s 2 a3 F J → 3d 2 4s 4p z 5 D J , visible transitions of Ti I. The measurements show without ambiguity the existence of a non-negligible field shift. Using the values of the nuclear radii of titanium (coming from muonic X-ray measurements), it is possible to determine the respective values of the field and mass shifts.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 31 (1994), S. 145-148 
    ISSN: 1434-6079
    Keywords: 32.70.Jz ; 31.30.Gs ; 35.10.Bg
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract High accuracy measurements of hyperfine structure due to47Ti and49Ti in the 3d 2 4s 2 a 3 F 2−3d 2 4s4p z 5 D 1 absorption line at σ=18482.772 cm−1 have been performed by use of a Doppler-free experiment, where a beam of titanium atoms is crossed by a CW single mode tunable dye laser. They have allowed for the determination of isotope shifts between46Ti,47Ti,48Ti,49Ti and50Ti. By use of accurate values of mean square nuclear charge radii for the even isotopes, it has been possible to separate mass shifts from field shifts and to determine accurate values for the mean square nuclear charge radii of47Ti and49Ti. The field shift presents a marked odd-even staggering.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Chemical Engineering & Technology - CET 15 (1992), S. 300-312 
    ISSN: 0930-7516
    Keywords: Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Thick-walled components subjected to pulsating internal pressure are widely applied in high-pressure technology and in manufacturing processes such as fluid-jet cutting and high-pressure cleaning, mainly in conjunction with reciprocating pumps. Corrosive fluids require high-strength and tough chrome-nickel steels with soft martensitic or semi-austenitic structure. This contribution reports on the fatigue of thick-walled plain and cross-bored pipes made from high alloy chrome-nickel steels such as X5 CrNiMoCu 21 8 and X5 CrNiMo 16 5. The speciments, uniaxial standard form and thick-walled pipes, were cut from forged blocks in the three axial directions. For loading with pulsating pressure, a suitable, high-frequency piston pulsation machine has been developed. The fatigue tests on pipe specimens show typical Woehler characteristics with only slight scatter and relatively good isotropy. The surprisingly large admissible pulsating pressure can be explained for the applied steels by dynamic generation of residual stresses as a result of shake-down effects. Presentation in a Smith digram explains the occuring dynamic shake-down and its favourable results in comparison to the more brittle highly tensile steels. It also reveals that heat treatment to higher tensile strength does not always yield an increase in the admissible pulsating pressure. It will be shown that static autofretting and shake-down affect the fatigue strength of thick-walled pipe specimens in the same way. Tests with internal liners in the tube specimens provide indications on the sensitivity of material failures towards fluids. The investigation aids the understanding of the fatigue behaviour and the design of components made of modern high-strength corrosion resistant steels.
    Additional Material: 20 Ill.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0930-7516
    Keywords: Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Titanium silicalite-1 samples of different particle size are synthesised and characterised by X-ray diffraction (XRD), photoelectron spectroscopy (XPS), diffuse reflectance spectroscopy (DRS), Raman and infrared spectroscopy. Size histograms are taken from transmission electron micrographs. Temporal changes of activity and selectivity for the hydroxylation of phenol and anisole are monitored. It is postulated that the p/o product ratios are due to the greater chemisorption of the ortho molecule.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 23 (1994), S. 379-379 
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1040-7685
    Keywords: capillary gas chromatography ; capillary supercritical fluid chromatography ; enantiomeric alcohols ; diastereomeric esters ; Trolox methyl ether ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The enantiomers of aliphatic alcohols are transformed by a new chiral reagent (S)-Trolox methyl ether to their diastereomeric esters which are separated by capillary GC or SFC on achiral columns. The applicability of this reagent and its superiority to the hitherto known reagents are demonstrated by selected examples.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 0009-286X
    Keywords: Dosieren ; Schüttguttechnik ; Schneckendosierer ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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