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  • Analytical Chemistry and Spectroscopy  (3)
  • Angiotensin II  (2)
  • 1990-1994  (5)
  • 1960-1964
  • 1
    Electronic Resource
    Electronic Resource
    Insulin enhances angiotensin II induced DNA synthesis in vascular smooth muscle cells of the rat (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 379-382 
    Details
    ISSN: 1432-1440
    Keywords: Angiotensin II ; Insulin ; Smooth muscle cell ; Vascular
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hypertension has a high prevalence among subjects with decreased insulin sensitivity and/or hyperinsulinemia. Furthermore, angiotensin II plays a pivotal role in the regulation of vascular tone and is known to induce hypertrophy and/or hyperplasia in vascular smooth muscle cells. In the present study, the effect of insulin on angiotensin II induced smooth muscle cell growth (Wistar-Kyoto rat) was investigated. Cell growth was assessed by the measurement of [3H]thymidine incorporation into cell DNA. Insulin in a concentration range of 1.7 × 10−10–1.7 × 10−6 M lacked any effect on cell DNA synthesis. However, insulin enhanced the angiotensin 11 induced DNA synthesis in a concentration-dependent manner. This effect was similar in cells with a weak and in cells with a marked response in DNA synthesis to stimulation with 100 nM angiotensin 11. In conclusion, insulin is able to enhance angiotensin 11 induced DNA synthesis and may therefore function as a growth cofactor in vascular smooth muscle cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00186627
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  • 2
    Electronic Resource
    Electronic Resource
    Inhibition of angiotensin II and platelet-derived growth factor-induced vascular smooth muscle cell proliferation by calcium entry blockers (1992)
    Springer
    Journal of molecular medicine 70 (1992), S. 113-117 
    Details
    ISSN: 1432-1440
    Keywords: Angiotensin II ; Diltiazem ; Mitogenic effect ; Nifedipine ; Platelet-derived growth factor ; Vascular smooth muscle cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Structural changes within the blood vessel wall such as hyperplasia and hypertrophy of vascular smooth muscle cells are important factors in the pathogenesis of hypertension. Humoral growth factors such as angiotensin II (AII) and platelet-derived growth factor BB (PDGF-BB) may participate in the remodelling of the blood vessel wall. Whether and by which mechanisms antihypertensive treatment is capable of influencing the structural blood vessel alterations to date remains unclear. In the present study, the effect of nifedipine and diltiazem on AII- and PDGF-BB-induced vascular smooth muscle cell proliferation was examined. Nifedipine and diltiazem at a concentration of 10 μM did not affect baseline DNA synthesis in isolated vascular smooth muscle cells in culture. AII (final concentration 100 nM) and PDGF-BB (50 ng/ml) stimulated DNA synthesis by approximately 9.0- and 4.6-fold, respectively. Both AII- and PDGF-BB-induced DNA synthesis was significantly blunted by diltiazem and nifedipine in a concentration of 10 μM, while no significant influence was seen with concentrations from 10 nM up to 1 μM. In contrast, no significant influence of these drugs could be observed on fetal calf serum 5%-induced DNA synthesis. The findings indicate that calcium antagonists possess antimitogenic potential and that they may thus contribute to the regression of structural changes of the blood vessels associated with hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00227350
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    F. W. McLafferty, F. Turecek. Interpretation of mass spectra. Fourth edition (1993). University Science Books, Mill Valley, California (1994)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 23 (1994), S. 379-379 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200230614
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    (S) -TroloxTM methyl ether, a powerful derivatizing reagent for the determination of the enantiomeric purity of chiral alcohols by GC and SFC with achiral columns (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Microcolumn Separations 4 (1992), S. 45-49 
    Details
    ISSN: 1040-7685
    Keywords: capillary gas chromatography ; capillary supercritical fluid chromatography ; enantiomeric alcohols ; diastereomeric esters ; Trolox methyl ether ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The enantiomers of aliphatic alcohols are transformed by a new chiral reagent (S)-Trolox methyl ether to their diastereomeric esters which are separated by capillary GC or SFC on achiral columns. The applicability of this reagent and its superiority to the hitherto known reagents are demonstrated by selected examples.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mcs.1220040109
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Gas chromatographic separation of polychlorinated biphenyls on a new apolar capillary column (1994)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 17 (1994), S. 851-858 
    Details
    ISSN: 0935-6304
    Keywords: High resolution gas chromatography ; Chlorinated hydrocarbons ; Polychlorinated biphenyls ; PCB indicator congeners ; Coelution ; Toxic PCB congeners ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Eighty one polychlorinated biphenyls (PCBs) and nineteen chlorinated pesticide standards have been analyzed on a newly developed apolar high resolution gas chromatography (HRGC) column. Emphasis was placed on the determination of PCB indicator congeners which are part of national regulations, and of toxic coplanar PCB congeners.The new column enables almost unambiguous quantification of the PCB indicator congeners (PCB 138 can be separated from both PCB 163 and PCB 164; PCB 28 and PCB 31 were also separated and no coelution was observed for PCB 52, PCB 118, and PCB 180). The new column furnished better results than CP-Sil 8 for the analysis of PCB indicator congeners in a sample of seal blubber.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240171208
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    Paper (German National Licenses)
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