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  • Aldosterone  (2)
  • 1990-1994  (1)
  • 1970-1974  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Aldosteron, Cortisol und Plasma-Renin-Aktivität beim Phäochromocytom (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 719-721 
    Details
    ISSN: 1432-1440
    Keywords: Aldosterone ; renin ; pheochromocytoma ; Aldosteron ; Renin ; Phaechromocytom
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Sieben von 8 Patienten mit einem Phäochromocytom zeigten eine über die Norm erhöhte Plasma-Renin-Aktivität (〉3 ng/ml/3 h). Bei 4 der 7 Patienten mit Hyperreninismus konnte gleichzeitig auch ein abnorm hohes Plasma-Aldosteron nachgewiesen werden (〉120 pg/ml). Seitengetrennte Bestimmungen der Plasma-Renin-Aktivität im Nierenvenenblut zweier Patienten zeigten, daß als Ursachen des Hyperreninismus sowohl eine Verringerung der Nierendurchblutung durch Tumorkompression im Sinne eines Goldblattmechanismus als auch eine Stimulation der renalen Reninsekretion durch Katecholamine in Frage kommen können. Bei 2 unserer Patienten mit einem Phäochromocytom fand sich eine über die Norm gesteigerte Cortisolsekretion.
    Notes: Summary Seven of eight patients with pheochromocytoma showed elevated plasma renin activity (〉3 ng/ml/3 hr). Four of these seven patients simultaneously had abnormally high plasma aldosterone (〉120 pg/ml). It was found by selective determinations of plasma renin activity in both renal veins that two different mechanisms may be responsible for the observed hyperreninism. Firstly, the pheochromocytoma can lead mechanically to a reduction in renal blood flow inducing an increased renin secretion. Secondly, catecholamines are known to stimulate renin secretion. Two of the eight patients with pheochromocytoma showed an increased cortisol secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01469334
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  • 2
    Electronic Resource
    Electronic Resource
    Primary aldosteronism: difference in clinical presentation and long-term follow-up between adenoma and bilateral hyperplasia of the adrenal glands (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 979-984 
    Details
    ISSN: 1432-1440
    Keywords: Adenoma ; Aldosterone ; Adrenalectomy ; Gynecomastia ; Hyperaldosteronism ; Hyperplasia ; Spironolactone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Since 1974 primary aldosteronism has been diagnosed in 71 patients in our outpatient clinic. Thirty-four patients had a unilateral aldosterone-producing adenoma, whereas bilateral adrenal hyperplasia was diagnosed in 37 patients. Although at the time of diagnosis the mean potassium values were lower and mean aldosterone levels were higher in patients with an adenoma, as compared to those with bilateral hyperplasia, these laboratory data did not allow us to differentiate between the two leading causes of primary aldosteronism in the individual patient due to pronounced overlap of laboratory values between the two groups. During the first few years, a successful differential diagnosis was made by adrenal phlebography and separate sampling of plasma aldosterone in both adrenal veins; later non-invasive imaging techniques such as computed tomography and radionuclide scanning were used. The best results were obtained in patients with adenoma who underwent adrenalectomy. Fifty-six percent of these patients were clinically and biochemically cured; 28% were improved and had normal blood pressure values during drug treatment. In contrast, patients with bilateral hyperplasia were treated pharmacologically, but only in half of the patients could normal blood pressure values be achieved. Two thirds of the male patients developed gynecomastia during spironolactone treatment. As expected, unilateral adrenalectomy was unsuccessful in the 7 patients with bilateral hyperplasia who underwent surgery. Our results confirm that surgical treatment of adrenal adenomas and drug treatment of bilateral hyperplasias are the appropriate therapy in primary aldosteronism. A differential diagnosis cannot be made on the basis of clinical and non-invasive laboratory data alone; imaging techniques have to be included in the diagnostic process. The long-term clinical outcome was more favorable in patients with an adrenal adenoma that can be removed surgically than in patients with idiopathic hyperplasia of both adrenal glands.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00577740
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    Paper (German National Licenses)
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