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  • 1
    Electronic Resource
    Electronic Resource
    Phosphatase Activity Toward Abnormally Phosphorylated τ: Decrease in Alzheimer Disease Brain (1995)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 65 (1995), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Microtubule-associated protein τ is abnormally hyperphosphorylated and aggregated in affected neurons of Alzheimer disease brain. This hyperphosphorylated τ can be dephosphorylated at some of the abnormal phosphorylated sites by purified protein phosphatase-1, 2A, and 2B in vitro. In the present study, we have developed an assay to measure protein phosphatase activity toward τ-1 sites (Ser199/Ser202) using the hyperphosphorylated τ isolated from Alzheimer disease brain as substrate. Using this assay, we have identified that in normal brain, protein phosphatase-2A and 2B and, to a lesser extent, 1 are involved in the dephosphorylation of τ. The Km values of dephosphorylation of the hyperphosphorylated τ by protein phosphatase-2A and 2B are similar. The τ phosphatase activity is decreased by ∼30% in brain of Alzheimer disease patients compared with those of age-matched controls. These findings suggest that a defect of protein phosphatase could be the cause of the abnormal hyperphosphorylation of τ in Alzheimer disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1995.65020732.x
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  • 2
    Electronic Resource
    Electronic Resource
    Hydroxylated Aromatic Inhibitors of HIV-1 Integrase (1995)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 38 (1995), S. 4171-4178 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00021a006
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  • 3
    Electronic Resource
    Electronic Resource
    Structure of PLi4 and Its Comparison with SiLi4, CLi4, and Li4: The Importance of Li-Li Interactions (1995)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 99 (1995), S. 4941-4946 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100014a012
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  • 4
    Electronic Resource
    Electronic Resource
    Efficient method for calculating the transmission coefficient of two-dimensional quantum wire structures (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 80 (1996), S. 4208-4210 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We present a very simple and efficient method for calculating the transmission coefficient of two-dimensional quantum wire structures based on the time-dependent solution of the Schrödinger equation. We apply the new method to a specific two-dimensional quantum wire structure. The new method is much faster than the finite element method and can be used to study electron transport in the presence of electron–phonon interaction and nonlinear interactions in the Schrödinger equation. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.363297
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  • 5
    Electronic Resource
    Electronic Resource
    Finite-size effect and its temperature dependence of giant magnetoresistance in magnetic granular materials : The 40th annual conference on magnetism and magnetic materials (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 79 (1996), S. 5587-5589 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: In magnetic granular alloys such as Co-Ag, a large finite-size effect in giant magnetoresistance (GMR) has been observed as the sample thickness (t) varies. The value of GMR monotonically decreases and eventually vanishes as t approaches zero. The t range, over which the GMR value drops rapidly to zero, has been found to be weakly dependent on temperature. Our results are consistent with a picture that a strong spin-orbit interaction at surfaces is responsible for randomizing spins in different spin channels, thus reducing GMR. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.362250
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  • 6
    Electronic Resource
    Electronic Resource
    Volume effects on the magnetic properties of R2Fe17-based quasiternary compounds (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 79 (1996), S. 2012-2015 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Structure and magnetic properties of the R2Fe17-based quasiternary compounds (R=Sm, Er, Gd, Y, Pr, Nd; M=Al, Ga) and their nitrides have been investigated. The saturation magnetization of R2Fe17−xMx compounds decreases with the increasing M content, while the M concentration dependence of the Curie temperature exhibits a maximum at about x=3.0 for the parent compounds. By nitrogenation the lattice parameters, the saturation magnetization, and the Curie temperature all have a corresponding increase compared with the parent alloys. The volume effects on the Curie temperature of these compounds have been studied. The d ln Tc/d ln V values were derived by comparing the change of the Curie temperature and volume before and after nitrogenation and show a linear dependence on the Curie temperatures for these systems investigated. This behavior can be quite well understood in terms of a combined model of localized and itinerant electrons suggesting more than 90% d electrons are localized, The same conclusion can be obtained from a analysis of the exchange field Hex dependence of the iron sublattice magnetization in the R2Fe17 compounds and their nitrides, and the iron proportionality constant VFe before and after nitrogenation. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.361054
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  • 7
    Electronic Resource
    Electronic Resource
    A hybrid quantum mechanical force field molecular dynamics simulation of liquid methanol: Vibrational frequency shifts as a probe of the quantum mechanical/molecular mechanical coupling (1996)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 104 (1996), S. 7261-7269 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: A hybrid quantum mechanical molecular dynamics method is used to study liquid methanol at room temperature and normal density. Frequencies of the twelve vibrational modes are calculated from the simulation data at the ab initio Hartree–Fock/3-21G(d,p) level. Good overall agreement is found between the experimental and calculated frequencies. Three different, successive levels of quantum mechanical/molecular mechanical (QM/MM) coupling schemes are investigated using gas-to-liquid vibrational frequency shifts as a probe. The results suggest, somewhat surprisingly, that the method with the weakest QM/MM coupling gives the best overall agreement between the experimental and simulated results for vibrational frequency shifts. The most elaborate coupling scheme overestimates the shifts towards the red direction due to overestimation of the attractive interactions between quantum mechanical and molecular mechanical molecules, while it is found to be most successful in describing the O–H stretch. The effects of the solvent on the geometrical parameters of methanol are investigated in detail. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.471439
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  • 8
    Electronic Resource
    Electronic Resource
    A Monte Carlo study of wetting transitions in polymer blends confined to a capillary (1996)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 104 (1996), S. 5294-5303 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We investigate the problem of wetting transitions in polymer blends confined to a slitlike adsorbing capillary of thickness H by Monte Carlo methods. Two paths for capillary wetting are considered, either along a path of increasing temperature, T, or increasing surface chemical potential, μ1. We find that H can be thought of as an additional thermodynamic parameter which controls the nature of the transitions. We find that there exists a capillary critical separation, Hc. For separations less than Hc the blend falls in the one phase region of the phase diagram. Above Hc there exists a separation Hbulk, where the polymer blend begins to show bulk behavior. Hbulk is shown to separate regions of first order transitions (H〈Hbulk) from critical wetting transitions (H≥Hbulk). Along a path of constant T and increasing μ1 we find for 2ξ〈H1〈H2〈Hbulk that the first-order transitions between the two separations is shifted according to μc1(H2)−μc1(H1)∝1/H1−1/H2. We discuss the implications of these results for the case of H→∞ and compare them with theoretical results. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.471258
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  • 9
    Electronic Resource
    Electronic Resource
    Polarizable point-charge model for water: Results under normal and extreme conditions (1996)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 105 (1996), S. 4742-4750 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Molecular dynamics simulations of liquid water under normal and extreme conditions are performed using the polarizable point-charge (PPC) model. This efficient three-site model explicitly incorporates results from ab initio studies of the water molecule in applied electric fields. The structural, thermodynamic, and dielectric properties, and the self-diffusion coefficient are examined at a number of temperatures ranging from 263 to 573 K. These simulation results are compared with available experimental data along the liquid–vapor coexistence line; the agreement is very good for all properties studied. The temperature of maximum density for the PPC model is found to coincide with the experimentally observed value of 277 K. The spatial coordination of water molecules in the liquid and the anisotropy of the self-diffusion tensor are analyzed at various state points. Increased directional anisotropy in the local translational diffusion, suggestive of prenucleation phenomena, can be observed at T=263 K. Above T=473 K the local translational anisotropy becomes rather insensitive to temperature variation indicating a weakening of the correlations between water molecules. Rototranslational dynamics and nonlinear polarization effects arising in polarizable models for water are discussed along with their phenomenological implications. The dimer properties for the PPC potential are also reported. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.472313
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  • 10
    Electronic Resource
    Electronic Resource
    Nonlinear I–V characteristics of a mesoscopic conductor (1999)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 86 (1999), S. 5094-5102 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We present a general theoretical formulation, based on nonequilibrium Green's functions, for nonlinear dc transport in multiprobe mesoscopic conductors. The theory is gauge invariant and is useful for the predictions of current–voltage characteristics and the nonequilibrium charge pileups inside the conductor. We have provided a detailed comparison between the gauge invariant scattering matrix theory and our theory. We have also given several examples where the I–V curve can be obtained analytically. The effects of exchange and correlation have been considered explicitly. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.371485
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