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  • 1
    ISSN: 1433-044X
    Keywords: Key words Replacement of ACL • Epidural analgesia • Tourniquet application • Thigh bandage • Compartment syndrome ; Schlüsselwörter Vordere Kreuzbandersatzplastik • Periduralanästhesie • Oberschenkelblutsperre • Straffer Verband • Kompartmentsyndrom
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wir berichten über einen Fall mit frühoperativem Kompartmentsyndroms der Tibialis-anterior-Loge mit vollständiger sensomotorischer Peronäusparese nach arthroskopisch assistierter vorderer Kreuzband (VKB-)rekonstruktion. Der Druck der Oberschenkelblutsperre betrug 360 mmHg, die Operationszeit 1,75 h. Postoperativ wurde das ganze Bein zur Thromboseprophylaxe mit einer elastischen Binde straff eingebunden. Die Analgesie erfolgte über eine kontinuierliche peridurale Bupivacain-Infusion. Unmittelbar postoperativ aufgetretene Schmerzen im Bereich des linken Unterschenkels wurden durch eine Erhöhung der Bupivacain-Menge gedämpft. Am 3. postoperativen Tag erfolgte schließlich wegen persistierender Schmerzen und unvermindert hohem Analgetikagebrauch die Verlegung ans Zentrumspital, wo bei druckdolenter und gespannter Tibialis-anterior-Loge und Kompartmentdruck über 100 mmHg die sofortige Logenspaltung durchgeführt wurde. Trotz fehlender Perfusion aller 3 Muskeln (M. tibialis anterior, M. extensor hallucis longus und M. extensor digitorum longus) wurde nur eine Logenspaltung ohne Débridement durchgeführt. Der nach 48 h durchgeführte „second-look“ zeigte nun eine partielle Reperfusion des Muskelgewebe mit Inseln ischämischer Nekrose ohne Nachweis von Kontraktilität. Klinisch bestand eine komplette Fußheberparese. Der Fall zeigt die Gefahr der Entstehung eines Kompartmentsyndroms infolge Kombination von Oberschenkelblutsperre, Arthroskopie und zu straff angelegtem Verband. Die kontinuierliche Periduralanalgesie beinhaltet dabei die Gefahr die klassischen klinischen Symptome zu verschleiern.
    Notes: Summary In this article we report a case of an early postoperative compartment syndrome of the anterior tibial compartment with complete sensomotoric palsy of the peroneal nerve after arthroscopic-assisted replacement of the anterior cruciate ligament (ACL) of the knee. The tourniquet pressure was 360 mm Hg and operation time was 1.75 h. After the operation the leg was bandaged to avoid swelling of the leg and as antithrombotic prophylaxis. Analgesic therapy was by continuous epidural bupivacaine infusion. Increasing pain of the lower leg was suppressed by additional analgesia. Due to persistent pain despite regular analgesia, the patient was sent to a main hospital on the 3rd postoperative day, where an extremely painful and swollen anterior tibial compartment with intracompartimental pressure of over 100 mm Hg was found. The compartment was released immediately. Despite the appearance of severe muscle damage, no extensive débridement was done. At the second examination, at 48 h, there was minimal perfusion of the muscles without contraction and islands of ischemic necrosis. Clinically, there was complete palsy of the dorsiflexors of the foot. The case shows the danger of a compartment syndrome when tourniquet of the limb, arthroscopy and a firm bandage are combined. Continuous epidural analgesia masks the classic symptoms of compartment syndrome.
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  • 2
    ISSN: 1432-0584
    Keywords: Key words Thalassemia ; Chelation ; Desferrioxamine ; Allergy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  In some patients compliance to subcutaneous desferrioxamine therapy is reduced because of allergic symptoms. Effective drug desensitization consists of bringing patients to tolerate the same mode of administration. We evaluated three thalassemic patients with severe allergies to desferrioxamine. Each patient received weekly three prefilled infusors with desferrioxamine 4 g/48 m1/48 h for s.c. therapy. Follow-up was performed for 12 consecutive weeks. During follow-up no allergic events were noted. The s-ferritin levels decreased from 2583 μg/l±485 to 1916 μg/l±275 (mean decrease 25.8%, p=0.038). Compliance to the infusional system was excellent. Our results show that continuous infusion of desferrioxamine using a new infusional delivery system is effective in preventing allergic reactions and in reducing iron overload.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0584
    Keywords: Key words Thalassemia intermedia ; Erythropoietin ; Radiotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We report a patient with thalassemia intermedia who developed a mediastinal syndrome due to the growth of paravertebral hematopoietic masses in the posterior mediastinum. Because the patient did not receive blood transfusions due to alloimmunization, she was first treated with human recombinant erythropoietin (escalating low-moderate doses) to recover hemoglobin levels, then in association with radiotherapy to prevent a worsening of her anemia. The mean Hb level dramatically increased and peaked at week 11, to 83 g/l, and remained unchanged before and after radiotherapy (81 versus 78 g/l). Immediately after radiotherapy extramedullary hematopoiesis volume decreased by 16.4%.
    Type of Medium: Electronic Resource
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