ISSN:
1573-6903
Keywords:
Manganese
;
melatonin
;
malondialdehyde formation
;
motor activity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In the present study, we have evaluated whether melatonin (MEL) modulates Mn-induced decrease in spontaneous motor activity (SMA) and lipid peroxidation, estimated as malondialdehyde (MDA) formation, in several brain regions. In mice treated with manganese a decrease in SMA after 2 weeks of treatment was observed. In the group treated with Mn+MEL a significant greater reduction in SMA was detected at 4 weeks. MDA levels were reduced in both MEL and Mn treated mice. In the animals treated with MEL + Mn a higher reduction in MDA levels was observed. These results suggest that MEL modulates the effect of Mn on SMA and brain lipid peroxidation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1021064711866
Permalink