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Single-step PCR amplification and enzyme restriction analysis of the entire Helicobacter pylori cytotoxin vacA gene for genetic variability studies (1999)

Perales, G ; Sanchez, J ; Mohar, A ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

FEMS microbiology letters 178 (1999), S. 0

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ISSN: 1574-6968

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Biology

Notes: To monitor changes along the entire Helicobacter pylori vacA gene we carried out full-length single-step PCR amplification in 21 gastritis and gastric cancer isolates. HindIII restriction analysis led us to detect a 〉400-bp internal insertion in vacA subsequently shown to be a direct 451-bp gene duplication. We found HindIII profiles for 16 genes that allowed their grouping into two restriction patterns that were related to theoretical profiles for previously sequenced Western genes. Comparisons with theoretical HindIII patterns for Japanese isolates appear suggestive of geographical H. pylori clonality. Full-length single-step PCR amplification seems suitable for quick restriction pattern assignment and detection of gene size changes.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1574-6968.1999.tb13759.x

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A model for long-term potentiation and depression (1995)

Migliore, M. ; Alicata, F. ; Ayala, G. F.

Springer

Journal of computational neuroscience 2 (1995), S. 335-343

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ISSN: 1573-6873

Keywords: computer simulations ; kinetic model ; LTD ; LTP ; retrograde messenger

Source: Springer Online Journal Archives 1860-2000

Topics: Computer Science , Medicine , Physics

Notes: Abstract A computational model of long-term potentiation (LTP) and long-term depression (LTD) in the hippocampus is presented. The model assumes the existence of retrograde signals, is in good agreement with several experimental data on LTP, LTD, and their pharmacological manipulations, and shows how a simple kinetic scheme can capture the essential characteristics of the processes involved in LTP and LTD. We propose that LTP and LTD could be two different but conceptually similar processes, induced by the same class of retrograde signals, and maintained by two distinct mechanisms. An interpretation of a number of experiments in terms of the molecular processes involved in LTP and LTD induction and maintenance, and the roles of a retrograde signal are presented and discussed.