In:
European Journal of Biochemistry, Wiley, Vol. 251, No. 1-2 ( 1998-01), p. 398-404
Abstract:
Cytochrome P ‐450 cam oxidises 1,2,3,4‐tetrahydro‐β‐carboline, an indolic alkaloid. We report here measurements of the product distribution of this oxidation. To rationalise the experimental results, ab initio quantum‐chemistry calculations of the product stabilities and molecular‐dynamics calculations of the substrate‐binding mode in the active site were performed. The calculations suggest that the product distribution is influenced by both the relative intrinsic gas‐phase stabilities of the monohydroxy products and by conformational rearrangement of the active site on substrate binding.
Type of Medium:
Online Resource
ISSN:
0014-2956
,
1432-1033
DOI:
10.1046/j.1432-1327.1998.2510398.x
Language:
English
Publisher:
Wiley
Publication Date:
1998
detail.hit.zdb_id:
1398347-7
detail.hit.zdb_id:
2172518-4
SSG:
12
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