In:
The Journal of Immunology, The American Association of Immunologists, Vol. 160, No. 6 ( 1998-03-15), p. 2665-2674
Abstract:
There have been no reports on an abundance of CD4−8−B220+ αβ T cells, seen in autoimmune mice carrying the lpr gene (abnormal Fas gene), in any immune organs of normal mice. We herein report, however, that such αβ T cells were abundant at intraepithelial sites of the appendix in normal mice. They lacked the expression of NK1.1 Ags (C57BL/6 mice), but had the morphology of granular lymphocytes and contained forbidden T cell clones in the minor lymphocyte-stimulating antigen (Mls) system (C3H/He mice with Mls-1b2a). In other words, many properties of intraepithelial T cells in the appendix resembled those ascribed to abnormal αβ T cells, which expand in the lymph nodes and spleen of lpr mice. In the case of lpr mice, CD4−8−B220+ αβ T cells first expanded in the appendix and then extended to other organs. CD4−8−B220+ αβ T cells seemed to originate in situ from c-kit+ stem cells in the appendix. These results suggest that the appendix is one of the primary sites in which CD4−8−B220+ αβ T cells exist, and that these cells carry many primordial properties as prototype T cells.
Type of Medium:
Online Resource
ISSN:
0022-1767
,
1550-6606
DOI:
10.4049/jimmunol.160.6.2665
Language:
English
Publisher:
The American Association of Immunologists
Publication Date:
1998
detail.hit.zdb_id:
1475085-5
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