In:
International Journal of Urology, Wiley, Vol. 6, No. 12 ( 1999-12), p. 600-606
Abstract:
Background : Ratio of free to total (F/T) prostate‐specific antigen (PSA) is higher in the blood of patients with benign prostatic hyperplasia than those with prostate cancer. To clarify the difference between ratios in these two, α‐1‐antichymotrypsin, the major component of the bound PSA in the blood, was immunohistochemically examined. Methods : Tissues were obtained surgically via a retropubic approach from patients with benign prostatic hyperplasia (nine cases) and prostate cancer (27 cases). These samples were processed in paraffin blocks, cut into 5 mm sections and stained with antibodies against α‐1‐antichymotrypsin and PSA. Results : The percentage of α‐1‐antichymotrypsin‐stained cells in prostate cancer was higher than that in benign prostatic hyperplasia ( P 〈 0.05). Almost all of glandular and cancer cells were stained with PSA antibody. The percentage of α‐1‐antichymotrypsin‐stained cells in prostate cancer did not correlate to histologic grade, although α‐1‐antichymotrypsin‐stained cells were more widely scattered in high grade tissues. No correlation was found between α‐1‐antichymotrypsin‐stained cells and ratio of F/T in the blood of cancer patients. In about 20% of cancer tissues, histiocytes with positive α‐1‐antichymotrypsin staining were found in stroma but not in that of benign prostatic hyperplasia. Conclusions : Prostate cancer tissues are shown to have a richer environment of α‐1‐antichymotrypsin than those of benign prostatic hyperplasia. Some cancer tissues contained α‐1‐antichymotrypsin‐stained histiocytes. These local events may correlate to a high amount of the bound form among total PSA in the blood of prostate cancer patients.
Type of Medium:
Online Resource
ISSN:
0919-8172
,
1442-2042
DOI:
10.1046/j.1442-2042.1999.00118.x
Language:
English
Publisher:
Wiley
Publication Date:
1999
detail.hit.zdb_id:
2009793-1
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