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  • 1
    Online Resource
    Online Resource
    SAGE Publications ; 1999
    In:  Vascular Surgery Vol. 33, No. 5 ( 1999-09), p. 471-479
    In: Vascular Surgery, SAGE Publications, Vol. 33, No. 5 ( 1999-09), p. 471-479
    Abstract: Postoperative hepatic failure is a significant yet unpredictable cause of death after elective aortic surgery. Routine preoperative evaluation is frequently insufficient to identify patients at risk. This study was designed to prospectively evaluate the utility of laparoscopy before aortic surgery in patients at a high risk for postoperative hepatic dysfunction. Patients at high risk for postoperative hepatic insufficiency were identified by history, physical examination, and routine blood work. Diagnostic laparoscopy was performed immediately before the planned aortic surgery through a single umbilical incision using standard technique. Liver biopsies were obtained in patients with equivocal findings. The planned operative procedure was undertaken based on the laparoscopic findings. The laparoscopic findings were correlated with those at laparotomy and the postoperative course. Eleven patients scheduled for aortic surgery (indication: aortoiliac occlusive disease [AIOD], five; abdominal aortic aneurysm [AAA] , four; renal artery stenosis [RAS], two) were deemed high risk for postoperative hepatic dysfunction owing to alcohol abuse (11 patients), hepatomegaly (1 patient), or laboratory abnormalities (4 patients). Laparoscopy was performed in all patients without complication and required 24 ± 13 minutes (± sd). Laparoscopy revealed a normal liver in three patients, mild liver disease in five, severe cirrhosis in two, and equivocal findings in one patient (frozen section biopsy showed normal liver). The planned aortic procedure (AIOD, aortobiiliac bypass [ABF] ; AAA, aortoaorto/aortobiiliac [ABI], RAS, bilateral aortorenal bypass) was performed in nine patients and aborted in the two patients with cirrhosis. The laparoscopic findings correlated reasonably well with those at laparotomy (identical, six patients, lapscope overestimate, two patients, lapscope underestimate, one patient). Postoperative hepatic failure and death occurred after aortic surgery (lapscope, normal liver) in one patient, and transient laboratory abnormalities were seen in two patients (lapscope, mild liver disease). The direct variable and total hospital costs for the laparoscopic study performed as an adjunct to the aortic surgery were $123 and $472 respectively. Diagnostic laparoscopy before aortic surgery is a safe, simple, inexpensive adjunct that may help further identify patients at high risk for postoperative hepatic dysfunction.
    Type of Medium: Online Resource
    ISSN: 0042-2835
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1999
    detail.hit.zdb_id: 2095223-5
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  • 2
    Online Resource
    Online Resource
    Elsevier BV ; 1997
    In:  Surgical Clinics of North America Vol. 77, No. 2 ( 1997-4), p. 381-395
    In: Surgical Clinics of North America, Elsevier BV, Vol. 77, No. 2 ( 1997-4), p. 381-395
    Type of Medium: Online Resource
    ISSN: 0039-6109
    Language: English
    Publisher: Elsevier BV
    Publication Date: 1997
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  • 3
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 1998
    In:  Circulation Vol. 97, No. 10 ( 1998-03-17), p. 1002-1008
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 97, No. 10 ( 1998-03-17), p. 1002-1008
    Abstract: Background —Platelet-rich arterial thrombi are resistant to lysis by plasminogen activators. However, the mechanisms underlying thrombolysis resistance are poorly defined. Plasminogen activator inhibitor-1 (PAI-1), which is present in plasma, platelets, and vascular endothelium, may be an important determinant of the resistance of arterial thrombi to lysis. However, in vitro studies examining the regulation of platelet-rich clot lysis by PAI-1 have yielded inconsistent results. Methods and Results —We developed a murine arterial injury model and applied it to wild-type ( PAI-1 +/+) and PAI-1–deficient ( PAI-1 −/−) animals. FeCl 3 was used to induce carotid artery thrombosis. Thrombi consisted predominantly of dense platelet aggregates, consistent with the histology of thrombi in large-animal arterial injury models and human acute coronary syndromes. To examine the role of PAI-1 in regulating endogenous clearance of platelet-rich arterial thrombi, thrombi were induced in 22 PAI-1 +/+ mice 14 PAI-1 −/− mice. Twenty-four hours later, the amount of residual thrombus was determined by histological analysis of multiple transverse sections of each artery. Residual thrombus was detected in 55 of 85 sections (64.7%) obtained from PAI-1 +/+ mice compared with 19 of 56 sections (33.9%) from PAI-1 −/− mice ( P =.009). Computer-assisted planimetry analysis revealed that mean thrombus cross-sectional area was 0.033±0.027 mm 2 in PAI-1 +/+ mice versus 0.016±0.015 mm 2 in PAI-1 −/− mice ( P =.048). Conclusions —PAI-1 is an important determinant of thrombolysis at sites of arterial injury. Application of this model to other genetically altered mice should prove useful for studying the molecular determinants of arterial thrombosis and thrombolysis.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 1998
    detail.hit.zdb_id: 1466401-X
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  • 4
    Online Resource
    Online Resource
    Wiley ; 1995
    In:  Journal of Biomedical Materials Research Vol. 29, No. 5 ( 1995-05), p. 647-653
    In: Journal of Biomedical Materials Research, Wiley, Vol. 29, No. 5 ( 1995-05), p. 647-653
    Type of Medium: Online Resource
    ISSN: 0021-9304 , 1097-4636
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 1995
    detail.hit.zdb_id: 2176174-7
    SSG: 12
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