In:
Clinical Physiology, Wiley, Vol. 19, No. 4 ( 1999-08), p. 338-343
Abstract:
99mTc‐ L , L ‐ethylenedicysteine ( 99m Tc‐EC) has been proposed as a 99m Tc‐labelled alternative to radio‐iodinated ortho‐ iodohippurate (OIH) for renal imaging and evaluation of renal function. The kinetics of this new renal function agent were studied by a single‐injection plasma clearance technique in pigs. 99m Tc‐EC, 131 I‐OIH and 125 I‐iothalamate were injected and the plasma concentration of the three tracers was followed for 240 min. Renal, hepatic and total plasma clearance were calculated. There was no difference between the renal plasma clearance of 99m Tc‐EC and 131 I‐OIH (175 ± 9 versus 178 ± 8 ml min −1 , P =0·43), whereas the difference between the total plasma clearance of 99m Tc‐EC and 131 I‐OIH was highly significant (268 ± 16 versus 185 ± 9 ml min −1 , P =0·0001). 99m Tc‐EC had a significant hepatic clearance of 83 ± 10 ml min −1 whereas the hepatic clearance of 131 I‐OIH was negligible. Renal plasma extraction of both 99m Tc‐EC and 131 I‐OIH decreased significantly between 2 and 240 min post‐injection from 0·85 to 0·45% for 99m Tc‐EC and from 0·93 to 0·57% for 131 I‐OIH. Red blood cell binding of 99m Tc‐EC and 131 I‐OIH was 6·1% and 20%, respectively. The protein binding of 99m Tc‐EC and 131 I‐OIH was 32% for both tracers. We conclude that 99m Tc‐EC is not a suitable tracer for measuring renal function by the single‐injection plasma clearance technique in pigs. This is due to a decreasing renal extraction and a significant hepatic clearance.
Type of Medium:
Online Resource
ISSN:
0144-5979
,
1365-2281
DOI:
10.1046/j.1365-2281.1999.00186.x
Language:
English
Publisher:
Wiley
Publication Date:
1999
detail.hit.zdb_id:
2004626-1
detail.hit.zdb_id:
2067524-0
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