In:
Respiration, S. Karger AG, Vol. 66, No. 2 ( 1999), p. 119-123
Abstract:
The aim of this study was to compare the bronchodilator effects of salbutamol delivered via three different devices: a dry-powder inhaler (DPI), a metered-dose inhaler (MDI) with a large-volume spacer and a jet nebulizer (NEB) in patients with stable chronic obstructive pulmonary disease (COPD). Ten male patients with stable COPD [age: 67.2 ± 3.8 years, forced expiratory volume in 1 s (FEV 〈 sub 〉 1 〈 /sub 〉 ): 1.56 ± 0.32 liters] were studied in a randomized, double-blind and crossover manner. Each patient received 200 or 1,000 µg salbutamol via an MDI with an InspirEase 〈 sup 〉 TM 〈 /sup 〉 spacer, a Rotahaler 〈 sup 〉 TM 〈 /sup 〉 , or a DeVilbiss 646 〈 sup 〉 TM 〈 /sup 〉 nebulizer (NEB), or matching placebo on 7 separate days. Spirometry was performed before and 15, 30, 60, 90, 120, and 240 min after inhalation. With the 200-µg dose, only DPI produced a small but greater response in maximum FEV 〈 sub 〉 1 〈 /sub 〉 and in area under the time-response curve (AUC-FEV 〈 sub 〉 1 〈 /sub 〉 ) compared with placebo. With the 1,000-µg dose, DPI and MDI produced equally greater improvements in both maximum FEV 〈 sub 〉 1 〈 /sub 〉 and AUC–FEV 〈 sub 〉 1 〈 /sub 〉 than NEB. An equal bronchodilating effect can be obtained using either DPI or MDI with a spacer device, whereas the NEB was less effective when the same dose was administered.
Type of Medium:
Online Resource
ISSN:
0025-7931
,
1423-0356
Language:
English
Publisher:
S. Karger AG
Publication Date:
1999
detail.hit.zdb_id:
1464419-8
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