In:
FEBS Letters, Wiley, Vol. 440, No. 3 ( 1998-12-04), p. 450-453
Abstract:
Streptozotocin (STZ)‐induced diabetic animals are vulnerable to cold stress. Uncoupling proteins (UCPs) play an important role in regulating thermogenesis. We investigated the gene expressions of UCPs in brown adipose tissue (BAT), white adipose tissue (WAT), liver and gastrocnemius muscle of STZ‐diabetic rats using Northern blot. UCP‐1, ‐2 and ‐3 mRNA expressions in BAT were all remarkably lower in STZ‐diabetic rats than those in control rats. Both UCP‐2 and ‐3 gene expressions in gastrocnemius muscle were substantially elevated in STZ‐diabetic rats and insulin treatment restored UCP gene expressions to normal levels. These results suggest that in STZ‐diabetic rats, the overexpression of UCP‐2 and UCP‐3 in skeletal muscle provides a defense against hypothermogenesis caused by decreased UCPs in BAT.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(98)01506-3
Language:
English
Publisher:
Wiley
Publication Date:
1998
detail.hit.zdb_id:
1460391-3
SSG:
12
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