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  • 1
    Online Resource
    Online Resource
    Elsevier BV ; 1998
    In:  Oceanologica Acta Vol. 21, No. 2 ( 1998-3), p. 307-318
    In: Oceanologica Acta, Elsevier BV, Vol. 21, No. 2 ( 1998-3), p. 307-318
    Type of Medium: Online Resource
    ISSN: 0399-1784
    Language: English
    Publisher: Elsevier BV
    Publication Date: 1998
    detail.hit.zdb_id: 2044478-3
    detail.hit.zdb_id: 435214-2
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  • 2
    Online Resource
    Online Resource
    Elsevier BV ; 1996
    In:  Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression Vol. 1307, No. 2 ( 1996-6), p. 162-170
    In: Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, Elsevier BV, Vol. 1307, No. 2 ( 1996-6), p. 162-170
    Type of Medium: Online Resource
    ISSN: 0167-4781
    RVK:
    Language: English
    Publisher: Elsevier BV
    Publication Date: 1996
    detail.hit.zdb_id: 2209522-6
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Geological Survey of Denmark and Greenland ; 1997
    In:  Geology of Greenland Survey Bulletin Vol. 176 ( 1997-06-01), p. 50-54
    In: Geology of Greenland Survey Bulletin, Geological Survey of Denmark and Greenland, Vol. 176 ( 1997-06-01), p. 50-54
    Abstract: The SIGMA project (Seismic Investigation of the Greenland MArgin) was designed to make accurate measurements of crustal thickness, velocity structure and seismic reflectivity along the hotspot-influenced volcanic rifted margin (VRM) off South-East Greenland (Fig. 1). SIGMA is a joint project between researchers at Woods Hole Oceanographic Institution (Woods Hole, Mass., USA) and the Danish Lithosphere Centre (DLC), and data was acquired on a cruise with R/V Maurice Ewing in August–October 1996. VRMs are characterised by a prism of igneous rocks that occupies the continent–ocean transition zone in an 80 to 150 km wide belt, several times thicker than normal oceanic crust, and which extends in some regions for more than 1500 km along strike. This thick igneous crust has two characteristics on seismic data: a seawarddipping reflector sequence (SDRS) interpreted as subaerially erupted basalt flows and intercalated volcanoclastics, and a high-velocity lower crust with P-wave velocities (7.2–7.6 km/s) suggestive of mafic to ultramafic intrusive rocks (Hinz, 1981; Mutter et al., 1982, 1984, 1988; Larsen & Jakobsdóttir, 1988; White & McKenzie, 1989; Holbrook & Kelemen, 1993). Several models for the thermal and mechanical processes involved in the formation of VRMs have been proposed, including: decompression melting during passive upwelling near a mantle plume (White & McKenzie, 1989); actively upwelling plume heads impinging on the base of the lithosphere (Richards et al., 1989; Duncan & Richards, 1991; Griffiths & Campbell, 1991); enhanced upper mantle convection driven by steep, cold lithospheric edges adjacent to the rift (Mutter et al., 1988) and hot upper mantle due to non-plume ‘hot cells’ or insulation by supercontinents (Gurnis, 1988). SIGMA consists of four transects systematically sampling the structure of the South-East Greenland margin and the continent–ocean transition at increasing distance from the Iceland hotspot track, in order to investigate the South-East Greenland VRM with respect to the following questions:1) What is the structure of the transition from continental to thick igneous crust, and thence to normal oceanic crust? Is the transition abrupt or gradual? To what extent does faulting play a role? Does the abruptness of the continent–ocean boundary change with distance from the Iceland plume? 2) What was the total volume of magmatism during continental breakup on the South-East Greenland margin and its conjugates, and how does it vary in space and time? How does this magmatism relate to distance from the Iceland plume and to its temporal magmatic budget? What is the proportion of plutonic to volcanic rocks, and how does this vary with distance from the hotspot track and with total crustal thickness? 3) Does high velocity lower crust exist beneath the margin, and if so, is there any evidence that its composition, thickness, and distribution change along strike? How might such changes relate to variations in melting conditions (temperature and degree of melting) with distance from the plume? 4) Is the structure of the South-East Greenland margin symmetrical with its conjugate margins on the Hatton–Rockall Bank and Iceland–Faeroes Ridge? What combinations of pure shear and simple shear processes might explain the conjugate structures?
    Type of Medium: Online Resource
    ISSN: 1397-1905
    Language: Unknown
    Publisher: Geological Survey of Denmark and Greenland
    Publication Date: 1997
    detail.hit.zdb_id: 1407831-4
    detail.hit.zdb_id: 2528601-8
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  • 4
    In: The Lancet, Elsevier BV, Vol. 350, No. 9084 ( 1997-10), p. 1065-1068
    Type of Medium: Online Resource
    ISSN: 0140-6736
    RVK:
    Language: English
    Publisher: Elsevier BV
    Publication Date: 1997
    detail.hit.zdb_id: 2067452-1
    detail.hit.zdb_id: 3306-6
    detail.hit.zdb_id: 1476593-7
    SSG: 5,21
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  • 5
    Online Resource
    Online Resource
    Informa UK Limited ; 1998
    In:  International Geology Review Vol. 40, No. 3 ( 1998-03), p. 189-216
    In: International Geology Review, Informa UK Limited, Vol. 40, No. 3 ( 1998-03), p. 189-216
    Type of Medium: Online Resource
    ISSN: 0020-6814 , 1938-2839
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 1998
    detail.hit.zdb_id: 2070023-4
    detail.hit.zdb_id: 2122950-8
    SSG: 13
    SSG: 7,41
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  • 6
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 28, No. 3 ( 1997-03), p. 593-596
    Abstract: Background and Purpose Microembolic high-intensity transient signals (HITS) on transcranial Doppler ultrasound (TCD) are associated with carotid stenosis, artificial heart valves, and other cardiac conditions. Only one case report describes stroke-related HITS in the posterior cerebral circulation. This study was designed to assess prospectively the prevalence of asymptomatic microemboli in vertebrobasilar ischemia and to determine whether potential cardioembolic sources, vertebral or basilar occlusive disease, and infarct subtypes predict the detection of HITS. Methods We investigated 52 consecutive patients with acute or recent vertebrobasilar ischemia within 48 hours after admission. TCD monitoring was performed according to established criteria for 20 minutes on each posterior cerebral artery. Fetal origin of the posterior cerebral artery was an exclusion criterion and ruled out by carotid compression. Results Microembolic signals were detected in 10 patients (19.2%). In a multivariate logistic regression analysis that included all independent variables, potential cardiac sources were significantly associated with HITS (odds ratio [OR], 14.3; 95% confidence interval [CI] , 1.6 to 128.4), in particular when more than one cardiac abnormality (OR, 32.7; CI, 4.1 to 259.3) or a high-risk source (OR, 14.0; 95% CI, 2.3 to 84.9) was found. Vertebrobasilar vessel lesions and infarct subtype were not related to the detection of microemboli. Conclusions Cardiac sources of embolism are a determinant of HITS in posterior cerebral circulation ischemia, suggesting that cardioembolic infarcts in that territory might be more common than suspected. Vertebrobasilar vessel abnormalities are less likely to lodge microemboli, which may indicate histopathological changes different from carotid artery disease.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    RVK:
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 1997
    detail.hit.zdb_id: 1467823-8
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  • 7
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 29, No. 6 ( 1998-06), p. 1167-1176
    Abstract: Purpose —The purpose of this study was to define the influence of feeding mean arterial pressure (FMAP) in conjunction with other morphological or clinical risk factors in determining the probability of hemorrhagic presentation in patients with cerebral arteriovenous malformations (AVMs). Methods —Clinical and angiographic data from 340 patients with cerebral AVMs from a prospective database were reviewed. Patients were identified in whom FMAP was measured during superselective angiography. Additional variables analyzed included AVM size, location, nidus border, presence of aneurysms, and arterial supply and venous drainage patterns. The presence of arterial aneurysms was also correlated with site of bleeding on imaging studies. Results —By univariate analysis, exclusively deep venous drainage, periventricular venous drainage, posterior fossa location, and FMAP predicted hemorrhagic presentation. When we used stepwise multiple logistic regression analysis in the cohort that had FMAP measurements (n=129), only exclusively deep venous drainage (odds ratio [OR], 3.7; 95% confidence interval [CI] , 1.4 to 9.8) and FMAP (OR, 1.4 per 10 mm Hg increase; 95% CI, 1.1 to 1.8) were independent predictors ( P 〈 0.01) of hemorrhagic presentation; size, location, and the presence of aneurysms were not independent predictors. There was also no association ( P =0.23) between the presence of arterial aneurysms and subarachnoid hemorrhage. Conclusions —High arterial input pressure (FMAP) and venous outflow restriction (exclusively deep venous drainage) were the most powerful risk predictors for hemorrhagic AVM presentation. Our findings suggest that high intranidal pressure is more important than factors such as size, location, and the presence of arterial aneurysms in the pathophysiology of AVM hemorrhage.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    RVK:
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 1998
    detail.hit.zdb_id: 1467823-8
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  • 8
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 29, No. 5 ( 1998-05), p. 931-934
    Abstract: Background and Purpose —Decisions on invasive arteriovenous malformation (AVM) treatment are currently based on natural-course risk estimates of AVM bleeding and assumptions on morbidity from cerebral hemorrhage in general. However, morbidity of AVM hemorrhage has rarely been reported. We sought to assess the morbidity of intracranial hemorrhage in patients with cerebral AVMs. Methods —From a prospective AVM database, 119 patients were analyzed: 115 had a hemorrhage as the diagnostic event, and 27 of them suffered a second hemorrhage during follow-up; an additional 4 patients had other diagnostic symptoms but bled during follow-up. The type (parenchymal, subarachnoid, intraventricular) and location of AVM hemorrhage were determined by CT/MR brain imaging. Disability and neurological impairment were assessed with the Barthel Index, the Rankin Scale, and the National Institutes of Health Stroke Scale, with a mean follow-up time of 16.2 months. Results —Of the 115 incident hemorrhages, 34 (30%) were subarachnoid, 27 (23%) parenchymal, 18 (16%) intraventricular, and 36 (31%) in combined locations. In 54 patients (47%; 95% confidence interval [CI], 38% to 56%) the incident hemorrhage resulted in no neurological deficit, and an additional 43 patients (37%; 95% CI, 28% to 46%) were independent in their daily activities (Rankin 1). Fifteen patients (13%; 95% CI, 7% to 19%) were moderately disabled (Rankin 2 or 3), and 3 (3%; 95% CI, 0% to 6%) were severely disabled (Rankin ≥4). Parenchymal hemorrhages were most likely to result in a neurological deficit (52%). Type and morbidity of hemorrhage during follow-up were similar to incident events. Twenty (74%) of 27 patients with both incident and follow-up hemorrhages were normal or independent (Rankin 0 or 1). None of the patients with a hemorrhage during follow-up died during the observation period. Conclusions —Hemorrhage from cerebral AVMs appears to have a lower morbidity than currently assumed. This finding encourages a reevaluation of the risks and benefits of invasive AVM treatment.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    RVK:
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 1998
    detail.hit.zdb_id: 1467823-8
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  • 9
    In: Cerebrovascular Diseases, S. Karger AG, Vol. 8, No. 2 ( 1998), p. 107-112
    Abstract: 〈 b 〉 Background and Purpose: 〈 /b 〉 Few data exist regarding to the occurrence of microembolic high-intensity transient signals (HITS) on transcranial Doppler ultrasound (TCD) in unselected acute stroke patients. The aim of this study was to investigate prospectively the frequency and determinants of HITS in acute carotid territory ischemia. We hypothesized that carotid artery disease, cardiac abnormalities, and nonlacunar infarcts were independent predictors of HITS in acute stroke. 〈 b 〉 Methods: 〈 /b 〉 We investigated 145 consecutive patients with acute internal carotid artery territory ischemia. The median time interval between stroke and TCD examination was 2 days. TCD monitoring was performed for 30 min on each middle cerebral artery. The frequency of HITS was cross-classified with carotid artery status, potential cardiac sources of embolism, and nonlacunar infarct subtype. Multivariate logistic regression models determined the independent relationship of these variables to HITS. 〈 b 〉 Results: 〈 /b 〉 Microembolic signals were detected in 35 patients (24.1%), Ipsilateral carotid artery disease was significantly and independently associated with HITS (odds ratio 3.3, 95% confidence interval 1.4–7.8, p = 0.007), whereas potential cardiac sources (OR 1.07, 95% CI 0.48–2.4, p = 0.84) and infarct subtype (OR 0.84, 95% CI 0.29–2.4, p = 0.75) were not. 〈 b 〉 Conclusions: 〈 /b 〉 High-intensity transient signals can be found in almost 25% of patients with acute anterior cerebral circulation ischemia and are significantly more prevalent among those with symptomatic carotid artery disease. Future clinical studies are required to determine whether HITS are a marker of increased stroke recurrence and can help to clarify stroke etiology in patients with competing stroke mechanisms.
    Type of Medium: Online Resource
    ISSN: 1015-9770 , 1421-9786
    Language: English
    Publisher: S. Karger AG
    Publication Date: 1998
    detail.hit.zdb_id: 1482069-9
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  • 10
    In: Inflammatory Bowel Diseases, Oxford University Press (OUP), Vol. 1, No. 1 ( 1995-21), p. 37-47
    Type of Medium: Online Resource
    ISSN: 1078-0998
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 1995
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