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  • m-Chlorophenylpiperazine  (2)
  • Chenopodium quinoa  (1)
  • DIVERSIFICATION  (1)
  • 1995-1999  (4)
Document type
Keywords
Publisher
Years
  • 1995-1999  (4)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Serotonergic modulation of anticholinergic effects on cognition and behavior in elderly humans (1995)
    Springer
    Psychopharmacology 120 (1995), S. 280-288 
    Details
    ISSN: 1432-2072
    Keywords: Scopolamine ; Ondansetron ; m-Chlorophenylpiperazine ; Cognitive pharmacologic modeling ; Geriatrics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cholinergic neurotransmission is thought to be modulated by serotonin as documented in animal and human studies. We examined the effects of the muscarinic antagonist scopolamine (0.4 mg IV) given alone or together with the serotonin mixed agonist/antagonistm-chlorophenylpiperazine (m-CPP, 0.08 mg/kg IV), and the selective 5-HT3 receptor antagonist ondansetron (0.15 mg/kg IV). Ten normal elderly volunteers each received five separate pharmacologic challenges (placebo, ondansetron, scopolamine, scopolamine + ondansetron, and scopolamine + m-CPP). Cognitive, behavioral, and physiologic variables were analyzed using repeated measures analysis of variance. The acute effects of scopolamine in certain cognitive, behavioral, and physiological measures were significantly exaggerated by the addition of m-CPP. Scopolamine's cognitive effects were unaffected by ondansetron at the dose tested, nor did ondansetron given alone affect basal cognitive performance. This pilot study suggests that the serotonin mixed agonist/antagonist m-CPP may influence cholinergic neurotransmission. The changes associated with the combination of scopolamine and m-CPP do not appear to be secondary to simple pharmacokinetic alterations and suggest a complex interaction between the cholinergic and serotonergic systems centrally.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02311175
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Evidence that 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced hyperthermia in rats is mediated by stimulation of 5-HT2A receptors (1995)
    Springer
    Psychopharmacology 117 (1995), S. 193-199 
    Details
    ISSN: 1432-2072
    Keywords: m-Chlorophenylpiperazine ; Ritanserin Spiperone ; Attenuated ; Tolerance ; MDL-72222 Propranolol ; Ketanserin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of various 5-HT receptor subtype-selective antagonists were studied on phenylisopropylamine hallucinogen1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced hyperthermia in Wistar rats, in an attempt to characterize the 5-HT receptor subtype mediating DOI-induced hyperthermia. Intraperitoneal administration of DOI to rats produced hyperthermia with a peak effect at 60 min. Pretreatment with propranolol (β-adrenoceptor antagonist that also has binding affinity for 5-HT1A, 5-HT1B and 5-HT2C sites), MDL-72222 or ondansetron (5-HT3 antagonists) did not attenuate DOI-induced hyperthermia. In contrast, pretreatment with metergoline (5-HT1/5-HT2 antagonist), ketanserin, LY53857, mesulergine, mianserin and ritanserin (5-HT2C/5-HT2A antagonists), as well as spiperone (5-HT1A/5-HT2A/D2 antagonist), significantly attenuated DOI-induced hyperthermia. Furthermore, daily administration of DOI (2.5 mg/kg per day) for 17 days did not produce either tolerance to its hyperthermic effect or modifym-CPP-induced hyperthermia in rats. These findings suggest that DOI-induced hyperthermia in rats is mediated by stimulation of 5-HT2A receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245187
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Stability of quantitative traits in quinoa (Chenopodium quinoa) (1996)
    Springer
    Theoretical and applied genetics 93 (1996), S. 110-116 
    Details
    ISSN: 1432-2242
    Keywords: Chenopodium quinoa ; Genotype-environment interaction ; Quinoa ; Stability ; Superiority
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The stability of various descriptive characters was studied over a 5-year period in 14 lines of quinoa (Chenopodium quinoa Willd.) to determine the most appropriate time in a breeding programme when selection for these characters could be performed, and which lines could serve as potential parents. Various measures of stability were employed to analyse these data, including those proposed by Francis and Kannenberg (1978) and Lin and Binns (1988), appropriately modified for the purpose of this investigation. From these results it was concluded that selection for height, inflorescence size and developmental stage could be satisfactorily performed at an early stage of the breeding programme. For saponin content, however, the measuring techniques available were too insensitive to enable a recommendation to be made. Potential parents were identified in this material for use in the development of varieties suitable for North European conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00225735
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  • 4
    Electronic Resource
    Electronic Resource
    Modeling Agricultural Production Strategies in the Northern Rio Grande Valley, New Mexico (1998)
    Springer
    Human ecology 26 (1998), S. 469-487 
    Details
    ISSN: 1572-9915
    Keywords: RISK ; DIVERSIFICATION ; GEOGRAPHIC INFORMATION SYSTEM ; SOUTHWESTERN PREHISTORY ; POPULATION PRESSURE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Energy, Environment Protection, Nuclear Power Engineering , Ethnic Sciences
    Notes: Abstract Diversification in agricultural techniques is a common strategy of risk minimization in nonindustrial societies. However, attribution of suboptimal behavior to risk minimization without consideration of the structure of risk and its environmental context obscures the complexity of agricultural decision-making. The productive potential of a prehistoric agricultural system that includes floodwater and dry farming and stream irrigation is modeled using Geographic Information System (GIS) analysis to evaluate whether diversification occurred as a response to population pressure or as a risk buffering strategy. The estimated productive potential of floodwater and irrigation farming is sufficient to have supported the estimated local population, suggesting that risk buffering is a more likely explanation. Floodwater farming and stream irrigation form a dual strategy that is effective at reducing risk. However, the potential of dry farming for subsistence production is insufficient for buffering more than a 2% productive shortfall. We propose that, within this generally risk-averse economy, dry farming was oriented toward the production of nonsubsistence crops such as cotton.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018760316892
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    Paper (German National Licenses)
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