In:
Journal of Occupational Health, Wiley, Vol. 40, No. 1 ( 1998-01), p. 50-54
Abstract:
The Effects of Allyl Chloride on Ca 2+ , Ca z+ ‐Free CaM, cAMP and Ca 24 /CaM‐PK II Activity in Nerve Cells: Keqin X ie , et at. Institute of Toxicology, Shandong Medical University —Nerve cells in a culture from chicken embryo brain were used to study the allyl chloride‐induced effects on the contents of intracellular Ca 2+ , Ca 2+ ‐free CaM, cAMP and the activity of Ca 2+ /CaM‐PK II. The results showed that with the increase in the concentration of allyl chloride there was a significant increase in the content of Ca 2+ and cAMP, and the activity of Ca 2 ~/CaM‐PK II in the cells (P 〈 0.01), but a marked decrease in Ca 2 + ‐free CaM (P 〈 0.01). The results suggest that the neurotoxicity of allyl chloride might be related to the increase in intracellular Ca 2+ and the activation of CaM and Ca 2+ /CaM‐PK II, eventually leading to the accumulation of degenerative MT in the nerve axon.
Type of Medium:
Online Resource
ISSN:
1341-9145
,
1348-9585
Language:
English
Publisher:
Wiley
Publication Date:
1998
detail.hit.zdb_id:
1340985-2
detail.hit.zdb_id:
2075956-3
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