In:
FEBS Letters, Wiley, Vol. 399, No. 1-2 ( 1996-12-09), p. 158-162
Abstract:
We previously found that retinoblastoma (RB) is cleaved at the initiation of apoptotic execution. Here we report that when an HL‐60 cell line resistant to cytosine arabinoside (Ara‐C) was exposed to this anticancer drug, neither RB cleavage nor apoptosis was detected. Consistent with that, processing of interleukin 1β‐converting enzyme (ICE) and CPP32 (an ICE‐like protease) was also prevented in these cells. In contrast, treatment of the HL‐60‐Ara‐C‐resistant cells with etoposide induced all of these apoptotic events. Furthermore, the etoposide‐induced RB cleavage was inhibited by a specific tetrapeptide ICE‐like inhibitor. Our results demonstrate that activation of the RB cleavage enzyme, an ICE‐like protease, is required for overcoming drug resistance.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(96)01311-7
Language:
English
Publisher:
Wiley
Publication Date:
1996
detail.hit.zdb_id:
1460391-3
SSG:
12
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