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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 93 (1996), S. 110-116 
    ISSN: 1432-2242
    Keywords: Chenopodium quinoa ; Genotype-environment interaction ; Quinoa ; Stability ; Superiority
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The stability of various descriptive characters was studied over a 5-year period in 14 lines of quinoa (Chenopodium quinoa Willd.) to determine the most appropriate time in a breeding programme when selection for these characters could be performed, and which lines could serve as potential parents. Various measures of stability were employed to analyse these data, including those proposed by Francis and Kannenberg (1978) and Lin and Binns (1988), appropriately modified for the purpose of this investigation. From these results it was concluded that selection for height, inflorescence size and developmental stage could be satisfactorily performed at an early stage of the breeding programme. For saponin content, however, the measuring techniques available were too insensitive to enable a recommendation to be made. Potential parents were identified in this material for use in the development of varieties suitable for North European conditions.
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 93 (1996), S. 110-116 
    ISSN: 1432-2242
    Keywords: Key words Chenopodium quinoa  ;  Genotype-environment interaction  ;  Quinoa  ;  Stability  ;  Superiority
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The stability of various descriptive characters was studied over a 5-year period in 14 lines of quinoa (Chenopodium quinoa Willd.) to determine the most appropriate time in a breeding programme when selection for these characters could be performed, and which lines could serve as potential parents. Various measures of stability were employed to analyse these data, including those proposed by Francis and Kannenberg (1978) and Lin and Binns (1988), appropriately modified for the purpose of this investigation. From these results it was concluded that selection for height, inflorescence size and developmental stage could be satisfactorily performed at an early stage of the breeding programme. For saponin content, however, the measuring techniques available were too insensitive to enable a recommendation to be made. Potential parents were identified in this material for use in the development of varieties suitable for North European conditions.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1939
    Keywords: Key words Dispersal ; Range expansion ; Distribution ; Pararge aegeria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Individuals colonizing unoccupied habitats typically possess characters associated with increased dispersal and, in insects, colonization success has been related to flight morphology. The speckled wood butterfly, Pararge aegeria, has undergone recent major expansions in its distribution: in the north of its range, P. aegeria has colonized many areas in north and east England, and in the south, it was first recorded on Madeira in 1976. We examined morphological traits associated with flight and reproduction in the northern subspecies tircis, and in the southern subspecies aegeria, from sites colonized about 20 years ago in northern England and on Madeira, respectively. Investment in flight was measured as relative wing area and thorax mass, and investment in reproduction as relative abdomen mass. All measurements were from individuals reared in a common environment and there were significant family effects in most of the variables measured. Compared with individuals from sites continuously occupied in recent history, colonizing individuals were larger (adult live mass). In the subspecies tircis, colonizing individuals also had relatively larger thoraxes and lower wing aspect ratios indicating that evolutionary changes in flight morphology may be related to colonization. However, sex by site interactions in analyses of thorax mass and abdomen mass suggest different selection pressures on flight morphology between the sexes in relation to colonization. Overall, the subspecies aegeria was smaller (adult live mass) and had a relatively larger thorax and wings, and smaller abdomen than subspecies tircis. Evolutionary changes in flight morphology and dispersal rate may be important determinants of range expansion, and may affect responses to future climate change.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1939
    Keywords: Key words Procellariiformes ; Nutrition ; Obesity ; Chick growth ; Life history
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Procellariiform seabirds such as short-tailed shearwaters Puffinus tenuirostris accumulate large quantities of lipid during the nestling period. The functional significance of this pattern of development remains unclear, but has been related both to temporal variation in feeding conditions around the colony and to stochastic variation in the foraging success of individual parents. This paper examines temporal and age-specific variation in the pattern of food delivery to nestling short-tailed shearwaters, which have one of the lowest provisioning rates of any procellariiforms and are known to experience occasional long intervals between feeds. We assess whether variation in the provisioning rates of chicks was associated primarily with temporal variation in food delivery at the level of the colony or with stochastic variation in food delivery at the level of the individual. We then discuss this variability in the context of nestling obesity. For all but the youngest chick age-classes, individual meals delivered by adults averaged 141 g, which was 25% of adult body mass. The proportion of chicks fed each night was low (49%) and highly variable (coefficient of variation = 82%), which means that occasional long intervals between feeds would be expected to arise simply by chance. In keeping with this, intervals between feeding events for individual chicks followed a negative exponential distribution with a mean of 2 nights and a maximum interval of 13 nights. There was significant temporal variation in food delivery, but deviations from expected values for both feeding frequency and meal size were restricted to a small number of nights, included values both higher and lower than expected and did not persist for more than 2 nights in succession. These data suggest that even among those species with very low feeding frequencies and occasional long intervals between feeds, nestling obesity in Procellariiformes should be regarded as a response to chronic stochastic variability in food delivery at the level of the individual chick rather than as insurance against sporadic temporal variation at the level of the colony.
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  • 5
    ISSN: 1432-0568
    Keywords: Key words Mouse ; Vasoactive intestinal peptide ; Postimplantation ; Growth factor ; Embryogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Activity-dependent neurotrophic factor is a potent, neuroprotective molecule released from astroglia following stimulation by vasoactive intestinal peptide and, at least in part, accounts for the neuroprotective actions of vasoactive intestinal peptide. As well as enhancing neuronal survival, vasoactive intestinal peptide is known to regulate embryonic growth during the early postimplantation period of development. The current study was designed to assess activity-dependent neurotrophic factor’s role in the growth-regulatory properties of vasoactive intestinal peptide. Treatment of whole cultured day-9 mouse embryos with activity-dependent neurotrophic factor (10–13 M) resulted in a growth of 3.1 somites, compared with 1.6 somites in control embryos after a 4 h incubation period. Significant increases were also seen in cross-sectional area, protein and DNA content and bromodeoxyuridine incorporation. Activity-dependent neurotrophic factor-treated embryos were morphologically indistinguishable from control embryos of the same size. Anti-activity-dependent neurotrophic factor ascites significantly inhibited growth. In addition, co-treatment of embryos with anti-activity-dependent neurotrophic factor ascites inhibited vasoactive intestinal peptide-stimulated growth. Although anti-vasoactive intestinal peptide treatment inhibited growth, it did not inhibit activity-dependent neurotrophic factor-induced growth. These data indicate that an activity-dependent neurotrophic factor-like substance is an endogenous and potent growth-promoting factor in the early postimplantation embryo and that vasoactive intestinal peptide-regulated growth of embryos occurs, at least in part, through the action of activity-dependent neurotrophic factor.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0428
    Keywords: Keywords Milk ; casein ; epidemiology ; immunosuppression ; beta-casomorphin.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Previously published Type I (insulin-dependent) diabetes mellitus incidence in 0 to 14-year-old children from 10 countries or areas was compared with the national annual cow milk protein consumption. Countries which were selected for study had appropriate milk protein polymorphism studies, herd breed composition information and low dairy imports from other countries. Total protein consumption did not correlate with diabetes incidence (r = + 0.402), but consumption of the β-casein A1 variant did (r = + 0.726). Even more pronounced was the relation between β-casein (A1 + B) consumption and diabetes (r = + 0.982). These latter two cow caseins yield a bioactive peptide β-casomorphin-7 after in vitro digestion with intestinal enzymes whereas the common A2 variant or the corresponding human or goat caseins do not. β-casomorphin-7 has opioid properties including immunosuppression, which could account for the specificity of the relation between the consumption of some but not all β-casein variants and diabetes incidence. [Diabetologia (1999) 42: 292–296]
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 97 (1998), S. 502-506 
    ISSN: 1432-2242
    Keywords: Key words Additivity ; Diallel cross ; Dominance ; Epistasis ; Wheat ; Yellow rust
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Complete F1 and F2 diallel crosses were used to investigate the inheritance of yellow rust resistance among eight bread wheat lines, developed by CIMMYT for the East African Highlands, which showed a wide response to this disease. Both diallel sets were grown at a site with a high incidence of yellow rust, although for one season, during which the F1 diallel was grown, disease incidence was unusually low. Analyses disclosed the presence of additive, dominance and epistatic effects among those genes controlling rust resistance, with the former being the most important. At normal disease levels, excluding two arrays having resistant common parents removed non-allelic interactions from the F1 diallels. For all F2 diallels, and the remaining F1 diallel, omitting two arrays based on susceptible parents removed these interactions. Local selection of material from a broadly based germplasm appears to be a feasible method of developing adapted cultivars resistant to endemic diseases.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-2242
    Keywords: Key words  Triticum aestivum ; Diallel cross ; Parent-offspring regression ; Realized heritability ; Yellow rust ; Yield
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Several methods are available for estimating heritability in disomic species, including parent-offspring regression, realized heritability, intraclass correlations of recombinant inbred lines, and diallel-cross analysis. Estimates were obtained by these various methods for a set of eight bread wheat (Triticum aestivum) lines adapted to the East African highlands, which had been intercrossed and selfed in a half-diallel arrangement to give F1, F2 and F3 generations, and F6 recombinant inbred lines. Significant genetic variation existed among parents and crosses for both grain yield and yellow rust resistance in all generations. Based on the heritability calculated from the analysis of F6 recombinant inbred lines, analysis of the F2 diallel crosses was recommended for determining the heritability of both characters in early segregating generations. The results also suggest that a form of tandem selection may be effective in developing locally adapted germplasm which combines high grain yield with yellow rust resistance.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-2072
    Keywords: m-Chlorophenylpiperazine ; Ritanserin Spiperone ; Attenuated ; Tolerance ; MDL-72222 Propranolol ; Ketanserin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of various 5-HT receptor subtype-selective antagonists were studied on phenylisopropylamine hallucinogen1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced hyperthermia in Wistar rats, in an attempt to characterize the 5-HT receptor subtype mediating DOI-induced hyperthermia. Intraperitoneal administration of DOI to rats produced hyperthermia with a peak effect at 60 min. Pretreatment with propranolol (β-adrenoceptor antagonist that also has binding affinity for 5-HT1A, 5-HT1B and 5-HT2C sites), MDL-72222 or ondansetron (5-HT3 antagonists) did not attenuate DOI-induced hyperthermia. In contrast, pretreatment with metergoline (5-HT1/5-HT2 antagonist), ketanserin, LY53857, mesulergine, mianserin and ritanserin (5-HT2C/5-HT2A antagonists), as well as spiperone (5-HT1A/5-HT2A/D2 antagonist), significantly attenuated DOI-induced hyperthermia. Furthermore, daily administration of DOI (2.5 mg/kg per day) for 17 days did not produce either tolerance to its hyperthermic effect or modifym-CPP-induced hyperthermia in rats. These findings suggest that DOI-induced hyperthermia in rats is mediated by stimulation of 5-HT2A receptors.
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  • 10
    ISSN: 1432-2072
    Keywords: Scopolamine ; Ondansetron ; m-Chlorophenylpiperazine ; Cognitive pharmacologic modeling ; Geriatrics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cholinergic neurotransmission is thought to be modulated by serotonin as documented in animal and human studies. We examined the effects of the muscarinic antagonist scopolamine (0.4 mg IV) given alone or together with the serotonin mixed agonist/antagonistm-chlorophenylpiperazine (m-CPP, 0.08 mg/kg IV), and the selective 5-HT3 receptor antagonist ondansetron (0.15 mg/kg IV). Ten normal elderly volunteers each received five separate pharmacologic challenges (placebo, ondansetron, scopolamine, scopolamine + ondansetron, and scopolamine + m-CPP). Cognitive, behavioral, and physiologic variables were analyzed using repeated measures analysis of variance. The acute effects of scopolamine in certain cognitive, behavioral, and physiological measures were significantly exaggerated by the addition of m-CPP. Scopolamine's cognitive effects were unaffected by ondansetron at the dose tested, nor did ondansetron given alone affect basal cognitive performance. This pilot study suggests that the serotonin mixed agonist/antagonist m-CPP may influence cholinergic neurotransmission. The changes associated with the combination of scopolamine and m-CPP do not appear to be secondary to simple pharmacokinetic alterations and suggest a complex interaction between the cholinergic and serotonergic systems centrally.
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