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  • Ovid Technologies (Wolters Kluwer Health)  (4)
  • 1995-1999  (4)
  • 1
    Online Resource
    Online Resource
    T −786 →C Mutation in the 5′-Flanking Region of the Endothelial Nitric Oxide Synthase Gene Is Associated With Coronary Spasm
    Ovid Technologies (Wolters Kluwer Health) ; 1999
    In:  Circulation Vol. 99, No. 22 ( 1999-06-08), p. 2864-2870
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 99, No. 22 ( 1999-06-08), p. 2864-2870
    Abstract: Background —Coronary spasm plays an important role in the pathogenesis of ischemic heart diseases in general. However, the precise mechanism(s) responsible for coronary spasm remains to be elucidated, and we examined the molecular genetics of coronary spasm. Methods and Results —We searched for the possible mutations in the endothelial nitric oxide synthase (eNOS) gene in patients with coronary spasm. In this study, we demonstrate the existence of 3 linked mutations in the 5′-flanking region of the eNOS gene (T −786 →C, A −922 →G, and T −1468 →A). The incidence of the mutations was significantly greater in patients with coronary spasm than in the control group ( P 〈 0.0001). Multiple logistic regression analysis with forward stepwise selection using the environmental risk factors and the eNOS gene variant revealed that the most predictive independent risk factor for coronary spasm was the mutant allele ( P 〈 0.0001). As assessed by luciferase reporter gene assays, the T −786 →C mutation resulted in a significant reduction in eNOS gene promoter activity ( P 〈 0.05), whereas neither the A −922 →G nor the T −1468 →A mutation had any affect. Conclusions —Taken together, these findings strongly suggest that the T −786 →C mutation in the eNOS gene reduces the endothelial NO synthesis and predisposes the patients with the mutation to coronary spasm.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/01.CIR.99.22.2864
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 1999
    detail.hit.zdb_id: 1466401-X
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  • 2
    Online Resource
    Online Resource
    Hereditary Multiple Glomus Tumors Involving the Glans Penis : A Case Report and Review of the Literature
    Ovid Technologies (Wolters Kluwer Health) ; 1995
    In:  Dermatologic Surgery Vol. 21, No. 10 ( 1995-10), p. 895-899
    Details
    In: Dermatologic Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 21, No. 10 ( 1995-10), p. 895-899
    Type of Medium: Online Resource
    ISSN: 1076-0512
    URL: Article
    DOI: 10.1111/j.1524-4725.1995.tb00719.x
    RVK:
    XA 53108
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 1995
    detail.hit.zdb_id: 2020062-6
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  • 3
    Online Resource
    Online Resource
    Long-Term Patency Rate of Right Internal Thoracic Artery Bypass Via the Transverse Sinus
    Ovid Technologies (Wolters Kluwer Health) ; 1998
    In:  Circulation Vol. 98, No. 19 ( 1998-11-10), p. 2043-2048
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 98, No. 19 ( 1998-11-10), p. 2043-2048
    Abstract: Background —Although concern regarding patency and possible compromise of graft blood flow by routing the right internal thoracic artery (RITA) through the transverse sinus has been raised, little is known about long-term patency. Methods and Results —To evaluate long-term patency of in situ RITA bypass via the transverse sinus, our first 115 patients (94 men, 21 women; mean age, 62.5 years; range, 13 to 77 years) who were alive in 1998 were enrolled for angiographic study. Only good-caliber grafts with no occlusion, string sign, or significant stenosis were considered patent. Early postoperative angiography had been performed 2 to 3 weeks after surgery in 114 patients. The early patency rates were 97.1% for RITA and 95.4% for left internal thoracic artery (LITA) grafts. Of 109 long-term survivors, 73 (67.0%) consented to have late angiographic restudy at a mean of 59 months (range, 9 to 93 months); 89.9% of RITA and 92.3% of LITA grafts were patent. Cumulative patency rates (actuarial curves) at 6 years were 89.3% (95% CI, 85% to 94%) for RITA and 94.5% (95% CI, 92% to 97%) for LITA, the differences not reaching statistical significance (multivariate Cox analysis). Conclusions —Our study demonstrated good long-term patency of in situ RITA bypass grafting via the transverse sinus for revascularization of the circumflex and diagonal arteries and supports its continued use.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/01.CIR.98.19.2043
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 1998
    detail.hit.zdb_id: 1466401-X
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  • 4
    Online Resource
    Online Resource
    Endothelial Nitric Oxide Synthase Gene Is Positively Associated With Essential Hypertension
    Ovid Technologies (Wolters Kluwer Health) ; 1998
    In:  Hypertension Vol. 32, No. 1 ( 1998-07), p. 3-8
    Details
    In: Hypertension, Ovid Technologies (Wolters Kluwer Health), Vol. 32, No. 1 ( 1998-07), p. 3-8
    Abstract: Abstract —Essential hypertension has a genetic basis. Accumulating evidence, including findings of elevation of arterial blood pressure in mice lacking the endothelial nitric oxide synthase (eNOS) gene, strongly suggests that alteration in NO metabolism is implicated in hypertension. There are, however, no reports indicating that polymorphism in the eNOS gene is associated with essential hypertension. We have identified a missense variant, Glu298Asp, in exon 7 of the eNOS gene and demonstrated that it is associated with both coronary spastic angina and myocardial infarction. To explore the genetic involvement of the eNOS gene in essential hypertension, we examined the possible association between essential hypertension and several polymorphisms including the Glu298Asp variant, variable number tandem repeats in intron 4 (eNOS4b/4a), and two polymorphisms in introns 18 and 23. We performed a large-scale study of genetic association using two independent populations from Kyoto (n=458; 240 normotensive versus 218 hypertensive subjects) and Kumamoto (n=421; 223 normotensive versus 187 hypertensive subjects), Japan. In both groups, a new coding variant, Glu298Asp, showed a strong association with essential hypertension (Kyoto: odds ratio, 2.3 [95% confidence interval, 1.4 to 3.9]; Kumamoto: odds ratio, 2.4 [95% confidence interval, 1.4 to 4.0] ). The allele frequencies of 298Asp in hypertensive subjects were significantly higher than those in normotensive subjects in both groups (Kyoto: 0.103 versus 0.050, P 〈 0.0017; Kumamoto: 0.120 versus 0.058, P 〈 0.0013, respectively). No such disequilibrium between genotypes was significantly associated with any other polymorphisms we examined; the Glu298Asp variant was also not linked to any other polymorphisms. In conclusion, the Glu298Asp missense variant was significantly associated with essential hypertension, which suggests that it is a genetic susceptibility factor for essential hypertension.
    Type of Medium: Online Resource
    ISSN: 0194-911X , 1524-4563
    URL: Article
    DOI: 10.1161/01.HYP.32.1.3
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 1998
    detail.hit.zdb_id: 2094210-2
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