In:
Journal of Vacuum Science & Technology A: Vacuum, Surfaces, and Films, American Vacuum Society, Vol. 13, No. 3 ( 1995-05-01), p. 1260-1266
Abstract:
The following is a continuation of our extensive investigations of the chemistry of complex silicate systems employing a combination of electron spectroscopy for chemical analysis and magic angle spinning nuclear magnetic resonance. In this case, we are beginning to provide unique chemical information that may have implications in the field of silicate-induced pathogenesis (e.g., asbestosis). Select silicate materials (such as amphiboles) have been investigated both before and following alterations of their physical conditions (e.g., crushing) and also before and after contact with certain in vitro cell cultures. In our studies to date, we have been able to track the ‘‘in-lattice’’ chemistry of the constituents of these, and related, silicates, determining such features as the simultaneous presence of aluminum in tetrahedral and octahedral sites of amphiboles, as well as the iron in M(4), as opposed to M(3) or M(1) octahedral positions of these amphiboles. We are comparing results for fibrous silicates with those achieved with related nonfibrous forms to try to confirm (or deny) the views of the biomedical community regarding the structural and chemical features of the fibrous silicates that are suspected to be primarily responsible for the pathogenic silicate behavior.
Type of Medium:
Online Resource
ISSN:
0734-2101
,
1520-8559
Language:
English
Publisher:
American Vacuum Society
Publication Date:
1995
detail.hit.zdb_id:
1475424-1
detail.hit.zdb_id:
797704-9
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