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  • 1995-1999  (1)
  • 1975-1979  (2)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    The effect of polycyclic hydrocarbons on the synthesis of DNA in lymphoid organs, bone marrow and regenerating rat liver (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 358-360 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Riassunto È esaminato l'effetto di sette idrocarburi policiclici, a diverso potere oncogeno, sulla sintesi del DNA nel timo, milza, midollo e fegato rigenerante di ratto. Il DMBA è inibente in tutti i tessuti esaminati, come pure il 1,2,3,4-DBA. Il BP ha un notevole effetto solo sul fegato rigenerante mentre il 1,2,3,4-DBA é più efficace dell'1,2,5,6-DBA in ogni caso. Non é stata stabilita una correlazione tra il potere oncogeno delle sostanze esaminate e la inibizione della sintesi del DNA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01922585
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Biomonitoring of exposure to ethylene oxide and propylene oxide by determination of hemoglobin adducts: correlations between airborne exposure and adduct levels (1999)
    Springer
    International archives of occupational and environmental health 72 (1999), S. 142-150 
    Details
    ISSN: 1432-1246
    Keywords: Key words Ethylene oxide ; Propylene oxide ; Hemoglobin adducts ; Biomarkers ; Exposure monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: Ethylene oxide (EO) and propylene oxide (PO) are important industrial chemicals. Exposure to these directly acting mutagens may be monitored by determination of their adducts to hemoglobin (Hb). This study establishes correlations between airborne concentrations of EO and PO and their Hb adducts in petrochemical workers. Methods: In three different studies conducted during maintenance shutdown of petrochemical plants the external occupational exposure to EO and PO was assessed by personal air monitoring (PAM). The internal exposure to EO and PO was concomitantly assessed by determination of N-(2-hydroxyethyl)valine (HOEtVal) and N-(3-hydroxypropyl)valine (HOPrVal) in blood samples of the operators using the N-alkyl-Edman degradation method. Results: In the first study, PAM was applied once a month at random over a period of 4 months. Blood samples for Hb-adduct determination were collected at the end of this period. No significant correlation was found between PAM and Hb-adduct data. In the next two studies, PAM was applied to the operators during the entire shift on every working day during the shutdown. Blood samples were collected before and immediately after the shutdown period. Highly significant correlations were found between the increment in the concentration of HOEtVal and HOPrVal over this period and the total exposure to EO and PO, respectively. Conclusions: Time-integrated exposure to EO or PO can be readily and reliably assessed by measurement of the concentration of HOEtVal or HOPrVal in a small blood sample. In workers occupationally exposed to low concentrations of EO or PO, good correlations were found between these Hb adducts and the airborne concentrations of EO and PO. These correlations allow the calculation of tentative biological exposure limits (BELs) for EO and PO. At the current Dutch occupational exposure limit (OEL) for EO (0.84 mg m−3, 8-h TWA) the BEL is 3.2 nmol HOEtVal/g globin. At the value of 10 mg m−3 (8-h TWA), which is currently being investigated as the new Dutch OEL for PO, the corresponding BEL is 5.3 nmol HOPrVal/g globin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004200050353
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Effect of urethan on the synthesis of nucleic acids in thymus, spleen, and bone marrow (1975)
    Springer
    Journal of cancer research and clinical oncology 84 (1975), S. 281-289 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Urethan, in a single dose of 1 mg/g body weight, exerts a strong inhibitory effect on DNA synthesis in lymphoid organs and bone marrow of rat. The inhibition observed in spleen and thymus is longer lasting than that exerted on bone marrow or regenerating liver, demonstrating a marked sensitivity of lymphoid cells to the drug. This effect can explain the rapid reduction of weight and cell number in thymus and spleen under urethan treatment, in absence of any lymphocytolytic action. The different effect of urethan on the different subpopulations of lymphoid cells therefore appears to be due to their kinetics rather than to a specific sensitivity of some of them.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00312249
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    Paper (German National Licenses)
    Fulltext
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