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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Lasers in medical science 11 (1996), S. 237-246 
    ISSN: 1435-604X
    Keywords: Fluorescence ; Time-resolved confocal microscopy ; Porphyrins ; Fluorescence polarization ; Photodynamic therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract The application of a novel time-resolved confocal fluorescence microspectrometer to studies of the distribution and speciation of porphyrin photosensitizers in rat C6 cerebral glioma cells is described. The instrument combines a mode-locked argon ion laser excitation source with time-correlated single photon counting fluorescence detection and has sub-micron spatial and sub-nanosecond temporal resolution. The porphyrins studied were haematoporphyrin derivative (HpD), haematoporphyrin IX (HP), porphyrinc (Pc) and the tetrakiscarborane carboxylate ester of 2,4-(α,β-dihydroxyethyl) deuteroporphyrin IX (BOPP). From the heterogeneous emission observed in vitro, assignments and spatial location of various porphyrin species are proposed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Entomologia experimentalis et applicata 78 (1996), S. 143-147 
    ISSN: 1570-7458
    Keywords: diapause ; insect-plant interactions ; phenology ; Salix repens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Nymphal development of Cacopsylla moscovita (And.) (Homoptera: Psylloidea) takes place only on female catkins of Salix repens L. and close phenological synchrony is crucial because development times of catkins and nymphs are similar. Eggs are laid on catkins as soon as they develop and close synchrony between oviposition and budburst maximizes time available for nymphal development. Sampling adult C. moscovita in the field revealed little synchrony between egg development and budburst, with over 60% of females containing mature eggs four weeks before catkins first appeared. In the laboratory, egg development was influenced by both temperature and photoperiod. At 10°C, egg development occurred approximately one month earlier than at 5°C and two weeks earlier than in the field. Adult survival in the laboratory was substantially reduced at increased temperature, with only 20% of adults surviving longer than two weeks at 10°C, compared with over 95% at 5°C. Body condition (weight corrected for size) of males and females decreased significantly in the field over winter. However, body condition of females levelled off before budburst, coincident with egg development implying that females had resumed feeding. We discuss our results in relation to regulation of phenological synchrony between oviposition and catkin appearance.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Astrophysics and space science 130 (1987), S. 125-126 
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract SW UMa is an unusual dwarf nova in several respects. Recent observations by Robinsonet al. (1986) have established that SW UMa is an SU UMa system, while Shafter, Szkody, and Thorstensen (1986) have presented evidence suggesting that SW UMa may be a DQ Her system as well. If the DQ Her classification is confirmed then SW UMa will be the only system to have this dual classification. Finally, time resolved spectroscopy of SW UMa has revealed the presence of an S-wave component in the Hα emission which has an unexpected phasing relative to the line wings.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Monatshefte für Chemie 118 (1987), S. 463-476 
    ISSN: 1434-4475
    Keywords: Electron spin resonance ; Polarography ; Ir ; Electronic spectra ; Cyclam type ligand
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Es wird über Infrarot-, Elektronenanregungs-, Elektronenspinresonanz- und D.C. Polarographie-Daten einiger tetraaza-makrocyclischer Kupfer(II)-Komplexe einschließlich eines neuen Cyclam-Typs als Ligand berichtet. Die Befunde werden hinsichtlich der Strukturen der Komplexe, dem Einfluß vonJahn-Teller-Verdrillungseffekten und Kation-Anion-Wechselwirkungen interpretiert.
    Notes: Abstract Infrared, electronic, electron spin resonance and d.c. polarographic data for some copper(II) tetraaza macrocyclic complexes, involving a novel cyclam type ligand, are reported and are interpreted in terms of the structure of the complexes and the influence ofJahn-Teller distortion effects and cation-anion interactions.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Rheumatology international 8 (1988), S. 55-59 
    ISSN: 1437-160X
    Keywords: Etretinate ; Rheumatoid arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Etretinate (Tigason; Roche), which is effective in the treatment of psoriatic arthritis has immunomodulating activity in vivo. We have therefore assessed this drug in an open clinical and biochemical assessment of 24 weeks duration in rheumatoid arthritis. The treatment dose was 1.0 mg/kg/day for the first 4 weeks reducing to 0.5 mg/kg/day thereafter. There was a modest clinical improvement though this only reached statistical significance for joint circumference at 12 and 16 weeks (P〈0.05). Biochemical improvement only reached levels of statistical significance for IgM at week 16 (P〈0.01). Eight out of 15 patients had discontinued the drug because of side-effects by week 12 and only three out of 15 patients showed individual improvement by week 24. Some biochemical parameters (ESR) worsened. These results suggest only modest clinical efficacy and use of the drug in rheumatoid arthritis is likely to be curtailed by unacceptable side-effects. The improvement in biochemical variables that occurs when the drug is used in psoriatic arthritis does not occur in rheumatoid arthritis.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Contributions to mineralogy and petrology 99 (1988), S. 113-125 
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Fine grained gabbroic chilled margins and crosscutting dikes are associated in space and time with three ca. 1400 Ma anorthositic plutons in the Flowers River area, southeastern Nain igneous complex. Both the anorthositic and gabbroic rocks have distinctive compositions compared to rocks of similar age and lithology elsewhere in northcentral Labrador. The anorthositic rocks contain olivine and augite rather than orthopyroxene, and Fe-Ti oxides, apatite and orthoclase are unusually abundant. Cumulus plagioclase is abnormally enriched in incompatible elements. Most of the gabbroic rocks are uniform in composition, although the effects of contamination and fractionation are evident in some places. They define a transitional to alkalic ferrogabbro magma that is strongly enriched in K, P and incompatible trace elements. The chemical characteristics of the ferrogabbro magma imply derivation from enriched mantle or involvement of a significant crustal component. A parent-daughter relationship between the ferrogabbro magma and anorthositic rocks is suggested by their compositional similarities and the fact that the gabbroic chilled margins and plagioclase-rich pluton interiors appear to be completely gradational in composition and texture.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    International journal of colorectal disease 2 (1987), S. 118-119 
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The necessity for follow-up after curative resection of colorectal cancer remains controversial. Many studies have failed to demonstrate the increase in survival which might be anticipated when detailed follow-up methods are used. In the United Kingdom no single policy has evolved. This study has examined, therefore, the current follow-up practice of a large group of British surgeons. Six per cent carried out no routine postoperative follow-up and there was great variation in the methods used and the regularity of visits. There is a need for a rational policy based on controlled studies to determine whether follow-up is of benefit to the patient and to identify the most effective methods.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0568
    Keywords: Key words Mouse ; Vasoactive intestinal peptide ; Postimplantation ; Growth factor ; Embryogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Activity-dependent neurotrophic factor is a potent, neuroprotective molecule released from astroglia following stimulation by vasoactive intestinal peptide and, at least in part, accounts for the neuroprotective actions of vasoactive intestinal peptide. As well as enhancing neuronal survival, vasoactive intestinal peptide is known to regulate embryonic growth during the early postimplantation period of development. The current study was designed to assess activity-dependent neurotrophic factor’s role in the growth-regulatory properties of vasoactive intestinal peptide. Treatment of whole cultured day-9 mouse embryos with activity-dependent neurotrophic factor (10–13 M) resulted in a growth of 3.1 somites, compared with 1.6 somites in control embryos after a 4 h incubation period. Significant increases were also seen in cross-sectional area, protein and DNA content and bromodeoxyuridine incorporation. Activity-dependent neurotrophic factor-treated embryos were morphologically indistinguishable from control embryos of the same size. Anti-activity-dependent neurotrophic factor ascites significantly inhibited growth. In addition, co-treatment of embryos with anti-activity-dependent neurotrophic factor ascites inhibited vasoactive intestinal peptide-stimulated growth. Although anti-vasoactive intestinal peptide treatment inhibited growth, it did not inhibit activity-dependent neurotrophic factor-induced growth. These data indicate that an activity-dependent neurotrophic factor-like substance is an endogenous and potent growth-promoting factor in the early postimplantation embryo and that vasoactive intestinal peptide-regulated growth of embryos occurs, at least in part, through the action of activity-dependent neurotrophic factor.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Applied physics 38 (1985), S. 17-21 
    ISSN: 1432-0649
    Keywords: 72.40 ; 85.60
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We present autocorrelation measurements showing the high-speed sampling and switching capabilities of SOS photoconducting elements which have been ion implanted with 60 and 160 keV Si28 ions. An analysis of the circuit shows the intrinsic photoconductive decay to be very fast (∼3.5 ps) and that the measured response is primarily limited by the gap capacitance and the associated R-C time.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0428
    Keywords: Keywords Milk ; casein ; epidemiology ; immunosuppression ; beta-casomorphin.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Previously published Type I (insulin-dependent) diabetes mellitus incidence in 0 to 14-year-old children from 10 countries or areas was compared with the national annual cow milk protein consumption. Countries which were selected for study had appropriate milk protein polymorphism studies, herd breed composition information and low dairy imports from other countries. Total protein consumption did not correlate with diabetes incidence (r = + 0.402), but consumption of the β-casein A1 variant did (r = + 0.726). Even more pronounced was the relation between β-casein (A1 + B) consumption and diabetes (r = + 0.982). These latter two cow caseins yield a bioactive peptide β-casomorphin-7 after in vitro digestion with intestinal enzymes whereas the common A2 variant or the corresponding human or goat caseins do not. β-casomorphin-7 has opioid properties including immunosuppression, which could account for the specificity of the relation between the consumption of some but not all β-casein variants and diabetes incidence. [Diabetologia (1999) 42: 292–296]
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