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  • 2000-2004  (7)
Document type
Publisher
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    HALYS AND QALYS AND DALYS, OH MY: Similarities and Differences in Summary Measures of Population Health (2002)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Public Health 23 (2002), S. 115-134 
    Details
    ISSN: 0163-7525
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Notes: Abstract Health-adjusted life years (HALYs) are population health measures permitting morbidity and mortality to be simultaneously described within a single number. They are useful for overall estimates of burden of disease, comparisons of the relative impact of specific illnesses and conditions on communities, and in economic analyses. Quality-adjusted life years (QALYs) and disability-adjusted life years (DALYs) are types of HALYs whose original purposes were at variance. Their growing importance and the varied uptake of the methodology by different U.S. and international entities makes it useful to understand their differences as well as their similarities. A brief history of both measures is presented and methods for calculating them are reviewed. Methodological and ethical issues that have been raised in association with HALYs more generally are presented. Finally, we raise concerns about the practice of using different types of HALYs within different decision-making contexts and urge action that builds and clarifies this useful measurement field.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.publhealth.23.100901.140513
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Analysis of the replicon region and identification of an rRNA operon on pBM400 of Bacillus megaterium QM B1551 (2001)
    Oxford, UK : Blackwell Science Ltd
    Molecular microbiology 39 (2001), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: An 18 633 bp region containing the replicon from the ≈ 53 kb pBM400 plasmid of Bacillus megaterium QM B1551 has been sequenced and characterized. This region contained a complete rRNA operon plus 10 other potential open reading frames (ORFs). The replicon consisted of an upstream promoter and three contiguous genes (repM400, orfB and orfC) that could encode putative proteins of 428, 251 and 289 amino acids respectively. A 1.6 kb minimal replicon was defined and contained most of repM400. OrfB was shown to be required for stability. Three 12 bp identical tandem repeats were located within the coding region of repM400, and their presence on another plasmid caused incompatibility with their own cognate replicon. Nonsense, frameshift and deletion mutations in repM400 prevented replication, but each mutation could be complemented in trans. RepM400 had no significant similarity to sequences in the GenBank database, whereas five other ORFs had some similarity to gene products from other plasmids and the Bacillus genome. An rRNA operon was located upstream of the replication region and is the first rRNA operon to be sequenced from B. megaterium. Its unusual location on non-essential plasmid DNA has implications for systematics and evolutionary biology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2958.2001.02292.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Mars' core and magnetism (2001)
    [s.l.] : Nature Publishing Group
    Nature 412 (2001), S. 214-219 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The detection of strongly magnetized ancient crust on Mars is one of the most surprising outcomes of recent Mars exploration, and provides important insight about the history and nature of the martian core. The iron-rich core probably formed during the hot accretion of Mars ∼4.5 billion years ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35084155
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  • 4
    Electronic Resource
    Electronic Resource
    Earth science Inside history in depth (2004)
    [s.l.] : Nature Publishing Group
    Nature 428 (2004), S. 476-477 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The basic divisions of Earth's internal structure (crust, mantle and core) have been known for a long time. But the evolutionary path that gave us this structure, and that provides the dynamics of plate tectonics, volcanism and magnetic-field generation, remains poorly understood. Why do we have ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/428476a
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  • 5
    Electronic Resource
    Electronic Resource
    Planetary science Volcanoes on Quaoar? (2004)
    [s.l.] : Nature Publishing Group
    Nature 432 (2004), S. 681-682 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Our planetary system does not end at Pluto. Hundreds of bodies exist in the Kuiper belt, which extends outwards from Pluto, sharing the same plane as the planetary orbits. The largest known bodies in the Kuiper belt are not much smaller than Pluto, and some have similar dynamics to that planet. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/432681a
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Planetary science Mission to Earth's core : a modest proposal (2003)
    [s.l.] : Nature Publishing Group
    Nature 423 (2003), S. 239-240 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Planetary missions have enhanced our understanding of the Solar System and how planets work, but no comparable exploratory effort has been directed towards the Earth's interior, where equally fascinating scientific issues are waiting to be investigated. Here I propose a scheme for a mission to ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/423239a
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  • 7
    Electronic Resource
    Electronic Resource
    Mapping and expression analysis of the human CASK gene (2000)
    Springer
    Mammalian genome 11 (2000), S. 934-937 
    Details
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003350010170
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    Paper (German National Licenses)
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