ISSN:
1608-3245
Keywords:
nucleic acids
;
combinatorial chemistry
;
aptamers
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract A method of irrational oligonucleotide design, SELEX, is considered. Individual SELEX products, aptamers, are small molecules (40–100 nt) that have a unique three-dimensional structure, which provides for their specific and high-affinity binding to targets varying from low-molecular-weight ligands to proteins. Thus, the sophisticated biosynthesis of recognizing protein elements, antibodies, can be emulated in vitro via selection and synthesis of principally new recognizing elements based on nucleic acids.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1026696330245
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